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Single-dose kinetics of deuterium-labelled cannabinol in man after intravenous administration and smoking.
Biomed Environ Mass Spectrom. 1987 Sep; 14(9):495-9.BE

Abstract

The single dose pharmacokinetics of deuterium-labelled cannabinol (2H2-CBN) were evaluated in six male cannabis users with different degree of abuse after smoking an average dose of 19 mg and after intravenous administration of 20 mg CBN. Plasma levels were measured for up to 72 h with selected ion monitoring by GC/MS using 2H7-CBN as internal standard. The systemic availability of smoked CBN was found to be 39 +/- 26% (min-max 6-65%). The mean plasma clearance was 19.1 +/- 2.6 ml min-1 kg-1 and the volume of distribution was determined to 50 +/- 23 l kg-1. The apparent terminal half lives for CBN were 32 +/- 17 h and 43 +/- 29 h after intravenous administration and smoking, respectively.

Authors+Show Affiliations

Department of Pharmacognosy, Uppsala University, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2960395

Citation

Johansson, E, et al. "Single-dose Kinetics of Deuterium-labelled Cannabinol in Man After Intravenous Administration and Smoking." Biomedical & Environmental Mass Spectrometry, vol. 14, no. 9, 1987, pp. 495-9.
Johansson E, Ohlsson A, Lindgren JE, et al. Single-dose kinetics of deuterium-labelled cannabinol in man after intravenous administration and smoking. Biomed Environ Mass Spectrom. 1987;14(9):495-9.
Johansson, E., Ohlsson, A., Lindgren, J. E., Agurell, S., Gillespie, H., & Hollister, L. E. (1987). Single-dose kinetics of deuterium-labelled cannabinol in man after intravenous administration and smoking. Biomedical & Environmental Mass Spectrometry, 14(9), 495-9.
Johansson E, et al. Single-dose Kinetics of Deuterium-labelled Cannabinol in Man After Intravenous Administration and Smoking. Biomed Environ Mass Spectrom. 1987;14(9):495-9. PubMed PMID: 2960395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-dose kinetics of deuterium-labelled cannabinol in man after intravenous administration and smoking. AU - Johansson,E, AU - Ohlsson,A, AU - Lindgren,J E, AU - Agurell,S, AU - Gillespie,H, AU - Hollister,L E, PY - 1987/9/1/pubmed PY - 1987/9/1/medline PY - 1987/9/1/entrez SP - 495 EP - 9 JF - Biomedical & environmental mass spectrometry JO - Biomed Environ Mass Spectrom VL - 14 IS - 9 N2 - The single dose pharmacokinetics of deuterium-labelled cannabinol (2H2-CBN) were evaluated in six male cannabis users with different degree of abuse after smoking an average dose of 19 mg and after intravenous administration of 20 mg CBN. Plasma levels were measured for up to 72 h with selected ion monitoring by GC/MS using 2H7-CBN as internal standard. The systemic availability of smoked CBN was found to be 39 +/- 26% (min-max 6-65%). The mean plasma clearance was 19.1 +/- 2.6 ml min-1 kg-1 and the volume of distribution was determined to 50 +/- 23 l kg-1. The apparent terminal half lives for CBN were 32 +/- 17 h and 43 +/- 29 h after intravenous administration and smoking, respectively. SN - 0887-6134 UR - https://www.unboundmedicine.com/medline/citation/2960395/Single_dose_kinetics_of_deuterium_labelled_cannabinol_in_man_after_intravenous_administration_and_smoking_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:2960395 DB - PRIME DP - Unbound Medicine ER -