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Statin Intolerance: Some Practical Hints.
Cardiol Clin. 2018 May; 36(2):225-231.CC

Abstract

Statin intolerance is the inability to tolerate a dose of statin required to sufficiently reduce cardiovascular risk. With the five-step approach, more than 90% of these patients might be treated with statins. The principal approaches are to try not to discontinue statin therapy and to treat these patients as effectively as possible. New therapies with the proprotein convertase subtilisin-kexin type 9 inhibitors and bempedoic acid might be an effective response to these needs. In case of lack of achieved goal of the therapy nutraceuticals with confirmed low-density lipoprotein cholesterol reduction properties may be considered as a part of the lipid-lowering combination therapy.

Authors+Show Affiliations

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz (MUL), 113 Zeromskiego Street, Lodz 90-549, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), 281/289 Rzgowska Street, Lodz 93-338, Poland; Cardiovascular Research Centre, University of Zielona Gora, 28 Zyty Street, Zielona Gora 65-046, Poland. Electronic address: maciejbanach@aol.co.uk.Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), Pond Street, London NW3 2QG, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29609752

Citation

Banach, Maciej, and Dimitri P. Mikhailidis. "Statin Intolerance: some Practical Hints." Cardiology Clinics, vol. 36, no. 2, 2018, pp. 225-231.
Banach M, Mikhailidis DP. Statin Intolerance: Some Practical Hints. Cardiol Clin. 2018;36(2):225-231.
Banach, M., & Mikhailidis, D. P. (2018). Statin Intolerance: Some Practical Hints. Cardiology Clinics, 36(2), 225-231. https://doi.org/10.1016/j.ccl.2017.12.004
Banach M, Mikhailidis DP. Statin Intolerance: some Practical Hints. Cardiol Clin. 2018;36(2):225-231. PubMed PMID: 29609752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin Intolerance: Some Practical Hints. AU - Banach,Maciej, AU - Mikhailidis,Dimitri P, Y1 - 2018/02/21/ PY - 2018/4/4/entrez PY - 2018/4/4/pubmed PY - 2018/9/19/medline KW - Adverse effects KW - Cardiovascular disease KW - Statin-associated muscle symptoms KW - Statins KW - Therapy SP - 225 EP - 231 JF - Cardiology clinics JO - Cardiol Clin VL - 36 IS - 2 N2 - Statin intolerance is the inability to tolerate a dose of statin required to sufficiently reduce cardiovascular risk. With the five-step approach, more than 90% of these patients might be treated with statins. The principal approaches are to try not to discontinue statin therapy and to treat these patients as effectively as possible. New therapies with the proprotein convertase subtilisin-kexin type 9 inhibitors and bempedoic acid might be an effective response to these needs. In case of lack of achieved goal of the therapy nutraceuticals with confirmed low-density lipoprotein cholesterol reduction properties may be considered as a part of the lipid-lowering combination therapy. SN - 1558-2264 UR - https://www.unboundmedicine.com/medline/citation/29609752/Statin_Intolerance:_Some_Practical_Hints_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0733-8651(17)30154-6 DB - PRIME DP - Unbound Medicine ER -