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Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study.
Int Braz J Urol. 2018 May-Jun; 44(3):600-607.IB

Abstract

OBJECTIVES

Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects.

MATERIALS AND METHODS

Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Patients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient's surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analysis in Java were used for evaluations. Statistical significant p was p<0.05.

RESULTS

There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statistical significant difference apoptosis index in immunochemical TUNEL dyeing and image software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1.

CONCLUSIONS

Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis.

Authors+Show Affiliations

Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey.Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey. Department of Urology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.Department of Pathology, Ataturk University School of Veterinary Medicine, Erzurum, Turkey.Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.Department of Anaesthesiology, Harran University School of Medicine, Sanliurfa, Turkey.Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey.Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29617082

Citation

Demir, Mehmet, et al. "Evaluation of Apoptosis Indexes in Currently Used Oral Alpha-blockers in Prostate: a Pilot Study." International Braz J Urol : Official Journal of the Brazilian Society of Urology, vol. 44, no. 3, 2018, pp. 600-607.
Demir M, Akin Y, Terim KAK, et al. Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study. Int Braz J Urol. 2018;44(3):600-607.
Demir, M., Akin, Y., Terim, K. A. K., Gulum, M., Buyukfirat, E., Ciftci, H., & Yeni, E. (2018). Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study. International Braz J Urol : Official Journal of the Brazilian Society of Urology, 44(3), 600-607. https://doi.org/10.1590/S1677-5538.IBJU.2017.0668
Demir M, et al. Evaluation of Apoptosis Indexes in Currently Used Oral Alpha-blockers in Prostate: a Pilot Study. Int Braz J Urol. 2018 May-Jun;44(3):600-607. PubMed PMID: 29617082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study. AU - Demir,Mehmet, AU - Akin,Yigit, AU - Terim,Kubra Asena Kapakin, AU - Gulum,Mehmet, AU - Buyukfirat,Evren, AU - Ciftci,Halil, AU - Yeni,Ercan, PY - 2017/12/17/received PY - 2018/02/22/accepted PY - 2018/4/5/pubmed PY - 2018/7/25/medline PY - 2018/4/5/entrez KW - 5-alpha Reductase Inhibitors KW - Prostate KW - Prostatic Hyperplasia SP - 600 EP - 607 JF - International braz j urol : official journal of the Brazilian Society of Urology JO - Int Braz J Urol VL - 44 IS - 3 N2 - OBJECTIVES: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects. MATERIALS AND METHODS: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Patients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient's surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analysis in Java were used for evaluations. Statistical significant p was p<0.05. RESULTS: There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statistical significant difference apoptosis index in immunochemical TUNEL dyeing and image software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1. CONCLUSIONS: Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis. SN - 1677-6119 UR - https://www.unboundmedicine.com/medline/citation/29617082/Evaluation_of_apoptosis_indexes_in_currently_used_oral_alpha-blockers_in_prostate:_a_pilot_study L2 - http://www.intbrazjurol.com.br/pdf/vol44n03/Demir_600_607.pdf DB - PRIME DP - Unbound Medicine ER -