Tags

Type your tag names separated by a space and hit enter

A case-control study of breast cancer and hormonal contraception in Costa Rica.
J Natl Cancer Inst. 1987 Dec; 79(6):1247-54.JNCI

Abstract

By 1981, 11% of married women in Costa Rica ages 20-49 years had used depot-medroxyprogesterone acetate (DMPA) and 58% had used oral contraceptives (OCs). Since 1977, the Costa Rican Ministry of Health has maintained a nationwide cancer registry. These circumstances provided an opportunity for a population-based, case-control study of DMPA, OCs, and breast cancer in Costa Rica. Cases were 171 women ages 25-58 years with breast cancer diagnosed between 1982 and 1984; controls were 826 women randomly chosen during a nationwide household survey. Cases and controls were interviewed with the use of a standard questionnaire covering their reproductive and contraceptive histories. Logistic regression methods were used to adjust for confounding factors. While few cases or controls had ever used DMPA, DMPA users had an elevated relative risk (RR) estimate of breast cancer of 2.6 (95% confidence limits = 1.4-4.7) compared with never users. However, no dose-response relationship was found; even the group of women who had used DMPA for less than 1 year had an elevated RR estimate (RR = 2.3; 95% confidence limits = 1.0-5.1). In contrast, OC users had no elevation in RR compared with never users (RR = 1.2; 95% confidence limits = 0.8-1.8). The results of the DMPA analysis are inconclusive. Before decisions are made on whether to continue providing this effective contraceptive method, other ongoing studies will need to confirm of refute these findings.

Authors+Show Affiliations

Lee NC
Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333.
Rosero-Bixby L
No affiliation info available
Oberle MW
No affiliation info available
Grimaldo C
No affiliation info available
Whatley AS
No affiliation info available
Rovira EZ
No affiliation info available

MeSH

AdultAge FactorsBreast NeoplasmsContraceptives, OralCosta RicaDelayed-Action PreparationsDemographyFemaleHumansMedroxyprogesteroneMedroxyprogesterone AcetateMiddle AgedRegistriesRisk Factors

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2961909

Citation

Lee, N C., et al. "A Case-control Study of Breast Cancer and Hormonal Contraception in Costa Rica." Journal of the National Cancer Institute, vol. 79, no. 6, 1987, pp. 1247-54.
Lee NC, Rosero-Bixby L, Oberle MW, et al. A case-control study of breast cancer and hormonal contraception in Costa Rica. J Natl Cancer Inst. 1987;79(6):1247-54.
Lee, N. C., Rosero-Bixby, L., Oberle, M. W., Grimaldo, C., Whatley, A. S., & Rovira, E. Z. (1987). A case-control study of breast cancer and hormonal contraception in Costa Rica. Journal of the National Cancer Institute, 79(6), 1247-54.
Lee NC, et al. A Case-control Study of Breast Cancer and Hormonal Contraception in Costa Rica. J Natl Cancer Inst. 1987;79(6):1247-54. PubMed PMID: 2961909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of breast cancer and hormonal contraception in Costa Rica. AU - Lee,N C, AU - Rosero-Bixby,L, AU - Oberle,M W, AU - Grimaldo,C, AU - Whatley,A S, AU - Rovira,E Z, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez KW - Americas KW - Breast Cancer KW - Cancer KW - Central America KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Costa Rica KW - Developing Countries KW - Diseases KW - Family Planning KW - Latin America KW - Medroxyprogesterone Acetate KW - Neoplasms KW - North America KW - Oral Contraceptives SP - 1247 EP - 54 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 79 IS - 6 N2 - By 1981, 11% of married women in Costa Rica ages 20-49 years had used depot-medroxyprogesterone acetate (DMPA) and 58% had used oral contraceptives (OCs). Since 1977, the Costa Rican Ministry of Health has maintained a nationwide cancer registry. These circumstances provided an opportunity for a population-based, case-control study of DMPA, OCs, and breast cancer in Costa Rica. Cases were 171 women ages 25-58 years with breast cancer diagnosed between 1982 and 1984; controls were 826 women randomly chosen during a nationwide household survey. Cases and controls were interviewed with the use of a standard questionnaire covering their reproductive and contraceptive histories. Logistic regression methods were used to adjust for confounding factors. While few cases or controls had ever used DMPA, DMPA users had an elevated relative risk (RR) estimate of breast cancer of 2.6 (95% confidence limits = 1.4-4.7) compared with never users. However, no dose-response relationship was found; even the group of women who had used DMPA for less than 1 year had an elevated RR estimate (RR = 2.3; 95% confidence limits = 1.0-5.1). In contrast, OC users had no elevation in RR compared with never users (RR = 1.2; 95% confidence limits = 0.8-1.8). The results of the DMPA analysis are inconclusive. Before decisions are made on whether to continue providing this effective contraceptive method, other ongoing studies will need to confirm of refute these findings. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/2961909/A_case_control_study_of_breast_cancer_and_hormonal_contraception_in_Costa_Rica_ DB - PRIME DP - Unbound Medicine ER -