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Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease.
J Pediatr Hematol Oncol. 2018 07; 40(5):348-354.JP

Abstract

In African-American children aged 5 to 17 years with and without type SS sickle cell disease (SCD-SS), dominant hand maximal handgrip strength, peak power, and plantar flexion isometric maximal voluntary contraction (MVC) torque were compared with adjustments for body size and composition. Children with SCD-SS (n=21; age, 11±1 y) compared with healthy control children (n=23; 10±1 y) did not differ by age, sex, or maturation stage, but had significantly lower Z scores for height, weight, body mass index, arm circumference, upper arm muscle area, and lean mass-for-height. Children with SCD-SS had significantly lower unadjusted handgrip strength (16±2 vs. 23±2 kg, P<0.01), peak power (1054±107 vs. 1488±169 W, P<0.04) and MVC torques at 2 angles (10 degrees: 27±3 vs. 42±5 Nm; 20 degrees: 21±3 vs. 34±4 Nm; all P<0.05). Performance decrements persisted when handgrip strength was adjusted for lean body mass and fat mass explaining 66% of the variance; peak power adjusted for age, lean body mass, fat mass, and height explaining 91% of the variance; and the highest MVC torque (10-degree angle) adjusted for left leg length, lean mass-for-height, and fat mass-for-height Z scores explaining 65% of the variance. This suggests additional factors contribute to the attenuated anaerobic performance.

Authors+Show Affiliations

School of Health Sciences, Stockton University, Galloway, NJ.University Hospital Umberto I, Sapienza University, Rome, Italy.Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia.Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Department of Pediatrics, Division of Hematology.Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29621064

Citation

Dougherty, Kelly A., et al. "Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease." Journal of Pediatric Hematology/oncology, vol. 40, no. 5, 2018, pp. 348-354.
Dougherty KA, Bertolaso C, Schall JI, et al. Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease. J Pediatr Hematol Oncol. 2018;40(5):348-354.
Dougherty, K. A., Bertolaso, C., Schall, J. I., Smith-Whitley, K., & Stallings, V. A. (2018). Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease. Journal of Pediatric Hematology/oncology, 40(5), 348-354. https://doi.org/10.1097/MPH.0000000000001143
Dougherty KA, et al. Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease. J Pediatr Hematol Oncol. 2018;40(5):348-354. PubMed PMID: 29621064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease. AU - Dougherty,Kelly A, AU - Bertolaso,Chiara, AU - Schall,Joan I, AU - Smith-Whitley,Kim, AU - Stallings,Virginia A, PY - 2018/4/6/pubmed PY - 2019/3/20/medline PY - 2018/4/6/entrez SP - 348 EP - 354 JF - Journal of pediatric hematology/oncology JO - J Pediatr Hematol Oncol VL - 40 IS - 5 N2 - In African-American children aged 5 to 17 years with and without type SS sickle cell disease (SCD-SS), dominant hand maximal handgrip strength, peak power, and plantar flexion isometric maximal voluntary contraction (MVC) torque were compared with adjustments for body size and composition. Children with SCD-SS (n=21; age, 11±1 y) compared with healthy control children (n=23; 10±1 y) did not differ by age, sex, or maturation stage, but had significantly lower Z scores for height, weight, body mass index, arm circumference, upper arm muscle area, and lean mass-for-height. Children with SCD-SS had significantly lower unadjusted handgrip strength (16±2 vs. 23±2 kg, P<0.01), peak power (1054±107 vs. 1488±169 W, P<0.04) and MVC torques at 2 angles (10 degrees: 27±3 vs. 42±5 Nm; 20 degrees: 21±3 vs. 34±4 Nm; all P<0.05). Performance decrements persisted when handgrip strength was adjusted for lean body mass and fat mass explaining 66% of the variance; peak power adjusted for age, lean body mass, fat mass, and height explaining 91% of the variance; and the highest MVC torque (10-degree angle) adjusted for left leg length, lean mass-for-height, and fat mass-for-height Z scores explaining 65% of the variance. This suggests additional factors contribute to the attenuated anaerobic performance. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/29621064/Muscle_Strength_Power_and_Torque_Deficits_in_Children_With_Type_SS_Sickle_Cell_Disease_ L2 - https://doi.org/10.1097/MPH.0000000000001143 DB - PRIME DP - Unbound Medicine ER -