Tags

Type your tag names separated by a space and hit enter

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats.
PLoS One. 2018; 13(4):e0195624.Plos

Abstract

Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life. Cassia obtusifolia L. (CO) and Foeniculum vulgare M. (FV) are commonly used as medicinal foods in many countries. We aimed to examine the laxative effect and their underlying mechanism of CO and FV mixture on loperamide (lop)-induced constipated rats. To determine the laxative effects of these compounds, Sprague-Dawley rats were divided into six groups: the control, lop-induced constipated (2mg/kg), and three doses (100, 300, and 500mg/kg) of CO and FV mixture-, and Bisacodyl (bis, 3.3mg/kg)-treated groups. The mixture of CO and FV and bis were orally administered once a day for 4 weeks. For induction of constipation, the lop were treated with a dose of 2 mg/kg twice a day on the 3rd week after treatments of CO and FV extracts and bis. The results were revealed that the CO and FV mixture has the laxative effects more than those in CO and FV-alone treatments on constipated rats by determining the stool parameters, including stool number and weight. Indeed, stool parameters, such as, stool number, weight, and water contents and colonic peristalsis from the intestinal transit length and ratio were dramatically improved by CO and FV mixture treatment. Histological study also revealed that CO and FV mixture enhanced the thicknesses of mucosa and muscular layers of the colon in constipated rats. For their underlying mechanism, the mRNAs and proteins expression of muscarinic acetylcholine receptors (mAchR) M2 and M3 and their downstream signaling were preserved by CO and FV mixture treatment in constipated rats. Therefore, this study suggests that treatment with CO and FV mixture has beneficial effects against constipation. We further suggest that CO and FV mixture may be utilized as an alternative therapeutic strategy for constipation.

Authors+Show Affiliations

Research & Development in TEAZEN, Inc., Anyang-si, Gyeonggi-do, Republic of Korea.Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chonbuk National University, Gobong-ro, Iksan-si, Jeollabuk-do, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29621360

Citation

Jang, Seung Hee, and Dong Kwon Yang. "The Combination of Cassia Obtusifolia L. and Foeniculum Vulgare M. Exhibits a Laxative Effect On Loperamide-induced Constipation of Rats." PloS One, vol. 13, no. 4, 2018, pp. e0195624.
Jang SH, Yang DK. The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. PLoS One. 2018;13(4):e0195624.
Jang, S. H., & Yang, D. K. (2018). The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. PloS One, 13(4), e0195624. https://doi.org/10.1371/journal.pone.0195624
Jang SH, Yang DK. The Combination of Cassia Obtusifolia L. and Foeniculum Vulgare M. Exhibits a Laxative Effect On Loperamide-induced Constipation of Rats. PLoS One. 2018;13(4):e0195624. PubMed PMID: 29621360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. AU - Jang,Seung Hee, AU - Yang,Dong Kwon, Y1 - 2018/04/05/ PY - 2017/12/14/received PY - 2018/03/26/accepted PY - 2018/4/6/entrez PY - 2018/4/6/pubmed PY - 2018/7/31/medline SP - e0195624 EP - e0195624 JF - PloS one JO - PLoS One VL - 13 IS - 4 N2 - Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life. Cassia obtusifolia L. (CO) and Foeniculum vulgare M. (FV) are commonly used as medicinal foods in many countries. We aimed to examine the laxative effect and their underlying mechanism of CO and FV mixture on loperamide (lop)-induced constipated rats. To determine the laxative effects of these compounds, Sprague-Dawley rats were divided into six groups: the control, lop-induced constipated (2mg/kg), and three doses (100, 300, and 500mg/kg) of CO and FV mixture-, and Bisacodyl (bis, 3.3mg/kg)-treated groups. The mixture of CO and FV and bis were orally administered once a day for 4 weeks. For induction of constipation, the lop were treated with a dose of 2 mg/kg twice a day on the 3rd week after treatments of CO and FV extracts and bis. The results were revealed that the CO and FV mixture has the laxative effects more than those in CO and FV-alone treatments on constipated rats by determining the stool parameters, including stool number and weight. Indeed, stool parameters, such as, stool number, weight, and water contents and colonic peristalsis from the intestinal transit length and ratio were dramatically improved by CO and FV mixture treatment. Histological study also revealed that CO and FV mixture enhanced the thicknesses of mucosa and muscular layers of the colon in constipated rats. For their underlying mechanism, the mRNAs and proteins expression of muscarinic acetylcholine receptors (mAchR) M2 and M3 and their downstream signaling were preserved by CO and FV mixture treatment in constipated rats. Therefore, this study suggests that treatment with CO and FV mixture has beneficial effects against constipation. We further suggest that CO and FV mixture may be utilized as an alternative therapeutic strategy for constipation. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29621360/The_combination_of_Cassia_obtusifolia_L__and_Foeniculum_vulgare_M__exhibits_a_laxative_effect_on_loperamide_induced_constipation_of_rats_ DB - PRIME DP - Unbound Medicine ER -