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Past, present and future of hepatitis E virus infection: Zoonotic perspectives.
Microb Pathog. 2018 Jun; 119:103-108.MP

Abstract

The origin of hepatitis E virus (HEV) is not fully understood, but it is considered an emerging zoonotic pathogen. To date, HEV has been isolated from many animal species. The family Hepeviridae consists of two genera. The genus Orthohepevirus includes four distinct species (A, B, C, and D), each with distinct genotypes. Within the Orthohepevirus A species, HEV-1 and HEV-2 host ranges are restricted to humans, whereas genotypes 3 and 4 primarily infect a wide range of diverse animal species, in addition to being zoonotic to humans. Swine and wild boar species were previously thought to be the primary natural HEV reservoir, but recently rabbits have also been identified as major carriers. Moreover, increasing the number of HEV infections within the food supply chain underscore the important role of farming and food processing practices in limiting virus transmission. Notably, a Chinese commercial vaccine has the potential to protect humans and possibly animal reservoirs from HEV infection. This review summarizes the status of HEV infection worldwide in different animal species and outlines various modes of zoonotic transmission, with reference to cross-species transmission and recent vaccine developments.

Authors+Show Affiliations

Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture, Water and Marine Sciences, Uthal, Balochistan 3800, Pakistan.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture, Water and Marine Sciences, Uthal, Balochistan 3800, Pakistan.Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.Faculty of Animal Husbandry and Veterinary Science, Sindh Agriculture University, Tandojam, Pakistan.Department of Veterinary Parasitology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan.Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture, Water and Marine Sciences, Uthal, Balochistan 3800, Pakistan.Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture, Water and Marine Sciences, Uthal, Balochistan 3800, Pakistan.Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture, Water and Marine Sciences, Uthal, Balochistan 3800, Pakistan. Electronic address: asifarain77@yahoo.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29621564

Citation

Syed, Shahid Faraz, et al. "Past, Present and Future of Hepatitis E Virus Infection: Zoonotic Perspectives." Microbial Pathogenesis, vol. 119, 2018, pp. 103-108.
Syed SF, Zhao Q, Umer M, et al. Past, present and future of hepatitis E virus infection: Zoonotic perspectives. Microb Pathog. 2018;119:103-108.
Syed, S. F., Zhao, Q., Umer, M., Alagawany, M., Ujjan, I. A., Soomro, F., Bangulzai, N., Baloch, A. H., Abd El-Hack, M., Zhou, E. M., & Arain, M. A. (2018). Past, present and future of hepatitis E virus infection: Zoonotic perspectives. Microbial Pathogenesis, 119, 103-108. https://doi.org/10.1016/j.micpath.2018.03.051
Syed SF, et al. Past, Present and Future of Hepatitis E Virus Infection: Zoonotic Perspectives. Microb Pathog. 2018;119:103-108. PubMed PMID: 29621564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Past, present and future of hepatitis E virus infection: Zoonotic perspectives. AU - Syed,Shahid Faraz, AU - Zhao,Qin, AU - Umer,Muhammad, AU - Alagawany,Mahmoud, AU - Ujjan,Imtiaz Ahmed, AU - Soomro,Feroza, AU - Bangulzai,Nasrullah, AU - Baloch,Abdul Hameed, AU - Abd El-Hack,Mohamed, AU - Zhou,En-Min, AU - Arain,Muhammad Asif, Y1 - 2018/04/03/ PY - 2018/03/14/received PY - 2018/03/26/revised PY - 2018/03/27/accepted PY - 2018/4/6/pubmed PY - 2018/10/16/medline PY - 2018/4/6/entrez KW - Hepatitis E virus KW - Reservoirs KW - Transmission KW - Vaccine KW - Zoonosis SP - 103 EP - 108 JF - Microbial pathogenesis JO - Microb Pathog VL - 119 N2 - The origin of hepatitis E virus (HEV) is not fully understood, but it is considered an emerging zoonotic pathogen. To date, HEV has been isolated from many animal species. The family Hepeviridae consists of two genera. The genus Orthohepevirus includes four distinct species (A, B, C, and D), each with distinct genotypes. Within the Orthohepevirus A species, HEV-1 and HEV-2 host ranges are restricted to humans, whereas genotypes 3 and 4 primarily infect a wide range of diverse animal species, in addition to being zoonotic to humans. Swine and wild boar species were previously thought to be the primary natural HEV reservoir, but recently rabbits have also been identified as major carriers. Moreover, increasing the number of HEV infections within the food supply chain underscore the important role of farming and food processing practices in limiting virus transmission. Notably, a Chinese commercial vaccine has the potential to protect humans and possibly animal reservoirs from HEV infection. This review summarizes the status of HEV infection worldwide in different animal species and outlines various modes of zoonotic transmission, with reference to cross-species transmission and recent vaccine developments. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/29621564/Past_present_and_future_of_hepatitis_E_virus_infection:_Zoonotic_perspectives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(18)30469-8 DB - PRIME DP - Unbound Medicine ER -