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Relationship between maternal exposure to bisphenol S and pregnancy duration.
Environ Pollut. 2018 Jul; 238:717-724.EP

Abstract

Bisphenol S (BPS) has been progressively used due to the potential safety problems of bisphenol A (BPA). Thus Human studies are needed to investigate the developmental effects of BPS. In this study, the impact of maternal BPS exposure on birth outcomes was evaluated with linear and logistic regression models. BPS was analyzed in spot urine samples collected from 985 pregnant women at admission to labor. It was found in 93.7% of the urine samples with the specific gravity adjusted geometric mean concentration of 0.17 μg/L. One ln-unit increase in urinary BPS was associated with a 0.72-day increase in pregnancy duration (95% CI: 0.34, 1.09). When stratified by fetal sex, each ln-unit increase in maternal urinary BPS was significantly correlated with increased gestational age [adjusted β = 1.02, 95% confidence intervals (CI): 0.47, 1.57] and increased odds of late term birth [adjusted odds ratio = 1.29, 95% CI: 1.00, 1.67] for girls, but not significantly for boys. Including maternal urinary BPA and BPS in one model did not change the results. Associations of BPS with birth weight or length were not observed. This is the first report about BPS exposure for pregnant women from China. Higher maternal urinary BPS concentrations were associated with increased gestational age, suggesting maternal BPS exposure may interfere with pregnancy duration. The findings require replication but reveal the probable risks posed by the developmental BPS exposure.

Authors+Show Affiliations

Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Institute of Environmental Health, Wuhan Center for Disease Control and Prevention, Wuhan, Hubei, PR China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Department of Environmental Health Sciences, Brown School of Public Health, Providence, RI 02903, USA.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China.Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: xiawei@hust.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29621731

Citation

Wan, Yanjian, et al. "Relationship Between Maternal Exposure to Bisphenol S and Pregnancy Duration." Environmental Pollution (Barking, Essex : 1987), vol. 238, 2018, pp. 717-724.
Wan Y, Huo W, Xu S, et al. Relationship between maternal exposure to bisphenol S and pregnancy duration. Environ Pollut. 2018;238:717-724.
Wan, Y., Huo, W., Xu, S., Zheng, T., Zhang, B., Li, Y., Zhou, A., Zhang, Y., Hu, J., Zhu, Y., Chen, Z., Lu, S., Wu, C., Jiang, M., Jiang, Y., Liu, H., Yang, X., & Xia, W. (2018). Relationship between maternal exposure to bisphenol S and pregnancy duration. Environmental Pollution (Barking, Essex : 1987), 238, 717-724. https://doi.org/10.1016/j.envpol.2018.03.057
Wan Y, et al. Relationship Between Maternal Exposure to Bisphenol S and Pregnancy Duration. Environ Pollut. 2018;238:717-724. PubMed PMID: 29621731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between maternal exposure to bisphenol S and pregnancy duration. AU - Wan,Yanjian, AU - Huo,Wenqian, AU - Xu,Shunqing, AU - Zheng,Tongzhang, AU - Zhang,Bin, AU - Li,Yuanyuan, AU - Zhou,Aifen, AU - Zhang,Yiming, AU - Hu,Jie, AU - Zhu,Yingshuang, AU - Chen,Zhong, AU - Lu,Shi, AU - Wu,Chuansha, AU - Jiang,Minmin, AU - Jiang,Yangqian, AU - Liu,Hongxiu, AU - Yang,Xueyu, AU - Xia,Wei, Y1 - 2018/04/03/ PY - 2017/11/22/received PY - 2018/03/16/revised PY - 2018/03/16/accepted PY - 2018/4/6/pubmed PY - 2018/8/3/medline PY - 2018/4/6/entrez KW - Birth weight KW - Bisphenol S KW - Gestational age KW - Pregnancy duration KW - Urine SP - 717 EP - 724 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 238 N2 - Bisphenol S (BPS) has been progressively used due to the potential safety problems of bisphenol A (BPA). Thus Human studies are needed to investigate the developmental effects of BPS. In this study, the impact of maternal BPS exposure on birth outcomes was evaluated with linear and logistic regression models. BPS was analyzed in spot urine samples collected from 985 pregnant women at admission to labor. It was found in 93.7% of the urine samples with the specific gravity adjusted geometric mean concentration of 0.17 μg/L. One ln-unit increase in urinary BPS was associated with a 0.72-day increase in pregnancy duration (95% CI: 0.34, 1.09). When stratified by fetal sex, each ln-unit increase in maternal urinary BPS was significantly correlated with increased gestational age [adjusted β = 1.02, 95% confidence intervals (CI): 0.47, 1.57] and increased odds of late term birth [adjusted odds ratio = 1.29, 95% CI: 1.00, 1.67] for girls, but not significantly for boys. Including maternal urinary BPA and BPS in one model did not change the results. Associations of BPS with birth weight or length were not observed. This is the first report about BPS exposure for pregnant women from China. Higher maternal urinary BPS concentrations were associated with increased gestational age, suggesting maternal BPS exposure may interfere with pregnancy duration. The findings require replication but reveal the probable risks posed by the developmental BPS exposure. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/29621731/Relationship_between_maternal_exposure_to_bisphenol_S_and_pregnancy_duration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(17)34820-0 DB - PRIME DP - Unbound Medicine ER -