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Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids.
Curr Pharm Biotechnol 2018; 19(2):113-123CP

Abstract

BACKGROUND

Synthetic opioids are compounds that were created to act on the opioid receptors. Novel synthetic opioids include various analogs of fentanyl (e.g., acetylfentanyl, acryloylfentanyl, carfentanil, furanylfentanyl, 4-fluorobutyrylfentanyl or ocfentanil) and newly emerging non-fentanyl compounds with different chemical structures, such as AH-7921, MT-45, and U-47700. In the last years, these drugs have rapidly emerged on the recreational drug market, and their abuse has been increasing worldwide. Due to the high potency and the low dose required to produce desired effects, the risk of overdose for these compounds including severe health implications, is quite high. Several fatal intoxication cases related to the abuse of synthetic opioids have recently been reported in the literature.

CONCLUSION

As a consequence, the detection of these compounds in biological samples is crucial in order to get a better understanding of their concentration and distribution in body fluids. We overviewed the analytical approaches for the investigation of synthetic opioids in postmortem samples reported in the literature, with special emphasis given to cases of lethal intoxication.

Authors+Show Affiliations

Centro Regionale Antidoping e di Tossicologia "A. Bertinaria" Regione Gonzole 10/1, 10043 Orbassano, Turin, Italy.Centro Regionale Antidoping e di Tossicologia "A. Bertinaria" Regione Gonzole 10/1, 10043 Orbassano, Turin, Italy.Centro Regionale Antidoping e di Tossicologia "A. Bertinaria" Regione Gonzole 10/1, 10043 Orbassano, Turin, Italy. Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, 10125 Turin, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29621965

Citation

Gerace, Enrico, et al. "Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids." Current Pharmaceutical Biotechnology, vol. 19, no. 2, 2018, pp. 113-123.
Gerace E, Salomone A, Vincenti M. Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids. Curr Pharm Biotechnol. 2018;19(2):113-123.
Gerace, E., Salomone, A., & Vincenti, M. (2018). Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids. Current Pharmaceutical Biotechnology, 19(2), pp. 113-123. doi:10.2174/1389201019666180405162734.
Gerace E, Salomone A, Vincenti M. Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids. Curr Pharm Biotechnol. 2018;19(2):113-123. PubMed PMID: 29621965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids. AU - Gerace,Enrico, AU - Salomone,Alberto, AU - Vincenti,Marco, PY - 2017/09/15/received PY - 2017/12/04/revised PY - 2018/03/24/accepted PY - 2018/4/7/pubmed PY - 2018/10/4/medline PY - 2018/4/7/entrez KW - AH-7941 KW - New psychoactive substances KW - U-47700 KW - fentanyl analogues KW - intoxication KW - postmortem KW - synthetic opioids. SP - 113 EP - 123 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 19 IS - 2 N2 - BACKGROUND: Synthetic opioids are compounds that were created to act on the opioid receptors. Novel synthetic opioids include various analogs of fentanyl (e.g., acetylfentanyl, acryloylfentanyl, carfentanil, furanylfentanyl, 4-fluorobutyrylfentanyl or ocfentanil) and newly emerging non-fentanyl compounds with different chemical structures, such as AH-7921, MT-45, and U-47700. In the last years, these drugs have rapidly emerged on the recreational drug market, and their abuse has been increasing worldwide. Due to the high potency and the low dose required to produce desired effects, the risk of overdose for these compounds including severe health implications, is quite high. Several fatal intoxication cases related to the abuse of synthetic opioids have recently been reported in the literature. CONCLUSION: As a consequence, the detection of these compounds in biological samples is crucial in order to get a better understanding of their concentration and distribution in body fluids. We overviewed the analytical approaches for the investigation of synthetic opioids in postmortem samples reported in the literature, with special emphasis given to cases of lethal intoxication. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/29621965/Analytical_Approaches_in_Fatal_Intoxication_Cases_Involving_New_Synthetic_Opioids L2 - http://www.eurekaselect.com/161048/article DB - PRIME DP - Unbound Medicine ER -