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Effects of three low-dose oral contraceptive formulations on lipid metabolism.
Acta Obstet Gynecol Scand. 1987; 66(4):327-32.AO

Abstract

Three oral contraceptive preparations were studied in 60 healthy women. This randomized, comparative, baseline controlled study was designed to investigate the effects of the preparations on plasma lipids and lipoproteins. The following formulations were studied: a monophasic preparation containing ethinylestradiol and desogestrel (M-DSG) and two triphasic formulations containing ethinylestradiol and gestodene or levonorgestrel respectively (T-GSD and T-LNG). These preparations were studied for six treatment cycles. Total cholesterol and apoprotein B did not change in any group. Low density lipoprotein (LDL) cholesterol was significantly decreased in the groups of women treated with M-DSG and T-GSD respectively. No changes were observed in the T-LNG group. With M-DSG, significant increases were observed in high-density lipoprotein (HDL) cholesterol and HDL3 cholesterol, whilst HDL2 cholesterol did not change. With both T-GSD and T-LNG, no changes were observed in HDL cholesterol, whilst a significant increase in HDL3 cholesterol together with a trend to decrease in HDL2 cholesterol were observed. Apolipoprotein AI increased with the following ranking M-DSG greater than T-GSD greater than T-LNG. The LDL/HDL cholesterol ratio significantly decreased with both M-DSG and T-GSD. In the T-LNG group there was no change in this ratio. Triglycerides increased to the same extent in all treatment groups. As far as concerns the risk of arterial diseases, these three oral contraceptive formulations mostly induced negligible and/or partly favorable changes in plasma lipids and lipoproteins; however, the lipoprotein pattern during M-DSG treatment resulted better than during T-GSD, and the latter turned out to be better than during T-LNG.

Authors+Show Affiliations

Department of Internal Medicine, University of Genoa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2962417

Citation

Bertolini, S, et al. "Effects of Three Low-dose Oral Contraceptive Formulations On Lipid Metabolism." Acta Obstetricia Et Gynecologica Scandinavica, vol. 66, no. 4, 1987, pp. 327-32.
Bertolini S, Elicio N, Cordera R, et al. Effects of three low-dose oral contraceptive formulations on lipid metabolism. Acta Obstet Gynecol Scand. 1987;66(4):327-32.
Bertolini, S., Elicio, N., Cordera, R., Gapitanio, G. L., Montagna, G., Croce, S., Saturnino, M., Balestreri, R., & De Cecco, L. (1987). Effects of three low-dose oral contraceptive formulations on lipid metabolism. Acta Obstetricia Et Gynecologica Scandinavica, 66(4), 327-32.
Bertolini S, et al. Effects of Three Low-dose Oral Contraceptive Formulations On Lipid Metabolism. Acta Obstet Gynecol Scand. 1987;66(4):327-32. PubMed PMID: 2962417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of three low-dose oral contraceptive formulations on lipid metabolism. AU - Bertolini,S, AU - Elicio,N, AU - Cordera,R, AU - Gapitanio,G L, AU - Montagna,G, AU - Croce,S, AU - Saturnino,M, AU - Balestreri,R, AU - De Cecco,L, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez KW - Biology KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods--side effects KW - Data Collection KW - Diseases KW - Endocrine System KW - Ethinyl Estradiol KW - Examinations And Diagnoses KW - Family Planning KW - Hormones KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Levonorgestrel KW - Lipid Metabolic Effects--analysis KW - Lipid Metabolic Effects--changes KW - Lipids KW - Metabolic Effects KW - Oral Contraceptives KW - Oral Contraceptives, Low-dose--side effects KW - Physiology KW - Prospective Studies KW - Reproductive Control Agents KW - Research Methodology KW - Studies SP - 327 EP - 32 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 66 IS - 4 N2 - Three oral contraceptive preparations were studied in 60 healthy women. This randomized, comparative, baseline controlled study was designed to investigate the effects of the preparations on plasma lipids and lipoproteins. The following formulations were studied: a monophasic preparation containing ethinylestradiol and desogestrel (M-DSG) and two triphasic formulations containing ethinylestradiol and gestodene or levonorgestrel respectively (T-GSD and T-LNG). These preparations were studied for six treatment cycles. Total cholesterol and apoprotein B did not change in any group. Low density lipoprotein (LDL) cholesterol was significantly decreased in the groups of women treated with M-DSG and T-GSD respectively. No changes were observed in the T-LNG group. With M-DSG, significant increases were observed in high-density lipoprotein (HDL) cholesterol and HDL3 cholesterol, whilst HDL2 cholesterol did not change. With both T-GSD and T-LNG, no changes were observed in HDL cholesterol, whilst a significant increase in HDL3 cholesterol together with a trend to decrease in HDL2 cholesterol were observed. Apolipoprotein AI increased with the following ranking M-DSG greater than T-GSD greater than T-LNG. The LDL/HDL cholesterol ratio significantly decreased with both M-DSG and T-GSD. In the T-LNG group there was no change in this ratio. Triglycerides increased to the same extent in all treatment groups. As far as concerns the risk of arterial diseases, these three oral contraceptive formulations mostly induced negligible and/or partly favorable changes in plasma lipids and lipoproteins; however, the lipoprotein pattern during M-DSG treatment resulted better than during T-GSD, and the latter turned out to be better than during T-LNG. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/2962417/Effects_of_three_low_dose_oral_contraceptive_formulations_on_lipid_metabolism_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=1987&volume=66&issue=4&spage=327 DB - PRIME DP - Unbound Medicine ER -