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HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY.
Acta Pol Pharm. 2017 Mar; 74(2):551-564.AP

Abstract

High shear wet granulation is a significant component procedure in the pharmaceutical industry. The objective of the study was to investigate the influence of two independent formulation variables; polyvinypyrrolidone (PVP) as a binder (X,) and croscarmellose sodium (CCS) as a disintegrant (X2) on the crit- ical quality attributes of acetaminophen granules and their corresponding tablets using design of experiment (DoE) approach. A two factor, three level (32) full factorial design has been applied; each variable was investi- gated at three levels to characterize their strength and interaction. The dried granules have been analyzed for their density, granule size and flowability. Additionally, the produced tablets have been investigated for: break- ing force, friability, disintegration time and t. of drug dissolution. The analysis of variance (ANOVA) showed that the two variables had a significant impact (p < 0.05) on granules and tablets characteristics, while only the binder concentration influenced the tablets friability. Furthermore, significant interactions (p < 0.05) between the two variables, for granules and tablets attributes, were also found. However, variables interaction showed minimal effect for granules flowability as well as tablets friability. Desirability function was carried out to opti- mize the variables under study to obtain product within the USP limit. It was found that the higher desirability (0.985) could be obtained at the medium level of PVP and low level of CCS. Ultimately, this study supplies the formulator with beneficial tools in selecting the proper level of binder and disintegrant to attain product with desired characteristics.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29624260

Citation

Fayed, Mohamed H., et al. "HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT of FORMULATION VARIABLES ON GRANULES and TABLETS CHARACTERISTICS of HIGH DRUG LOADING FORMULATION USING DESIGN of EXPERIMENT METHODOLOGY." Acta Poloniae Pharmaceutica, vol. 74, no. 2, 2017, pp. 551-564.
Fayed MH, Abdel-Rahman SI, Alanazi FK, et al. HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY. Acta Pol Pharm. 2017;74(2):551-564.
Fayed, M. H., Abdel-Rahman, S. I., Alanazi, F. K., Ahmed, M. O., Tawfeek, H. M., & Ali, B. E. (2017). HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY. Acta Poloniae Pharmaceutica, 74(2), 551-564.
Fayed MH, et al. HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT of FORMULATION VARIABLES ON GRANULES and TABLETS CHARACTERISTICS of HIGH DRUG LOADING FORMULATION USING DESIGN of EXPERIMENT METHODOLOGY. Acta Pol Pharm. 2017;74(2):551-564. PubMed PMID: 29624260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY. AU - Fayed,Mohamed H, AU - Abdel-Rahman,Sayed I, AU - Alanazi,Fars K, AU - Ahmed,Mahrous O, AU - Tawfeek,Hesham M, AU - Ali,Bahaa E, PY - 2018/4/7/entrez PY - 2018/4/7/pubmed PY - 2018/5/4/medline SP - 551 EP - 564 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 74 IS - 2 N2 - High shear wet granulation is a significant component procedure in the pharmaceutical industry. The objective of the study was to investigate the influence of two independent formulation variables; polyvinypyrrolidone (PVP) as a binder (X,) and croscarmellose sodium (CCS) as a disintegrant (X2) on the crit- ical quality attributes of acetaminophen granules and their corresponding tablets using design of experiment (DoE) approach. A two factor, three level (32) full factorial design has been applied; each variable was investi- gated at three levels to characterize their strength and interaction. The dried granules have been analyzed for their density, granule size and flowability. Additionally, the produced tablets have been investigated for: break- ing force, friability, disintegration time and t. of drug dissolution. The analysis of variance (ANOVA) showed that the two variables had a significant impact (p < 0.05) on granules and tablets characteristics, while only the binder concentration influenced the tablets friability. Furthermore, significant interactions (p < 0.05) between the two variables, for granules and tablets attributes, were also found. However, variables interaction showed minimal effect for granules flowability as well as tablets friability. Desirability function was carried out to opti- mize the variables under study to obtain product within the USP limit. It was found that the higher desirability (0.985) could be obtained at the medium level of PVP and low level of CCS. Ultimately, this study supplies the formulator with beneficial tools in selecting the proper level of binder and disintegrant to attain product with desired characteristics. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/29624260/HIGH_SHEAR_GRANULATION_PROCESS:_ASSESSING_IMPACT_OF_FORMULATION_VARIABLES_ON_GRANULES_AND_TABLETS_CHARACTERISTICS_OF_HIGH_DRUG_LOADING_FORMULATION_USING_DESIGN_OF_EXPERIMENT_METHODOLOGY_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2017/2/551.pdf DB - PRIME DP - Unbound Medicine ER -