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DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE.
Acta Pol Pharm. 2017 Mar; 74(2):565-578.AP

Abstract

The objective of this study was to prepare and evaluate ivabradine HCl-loaded microspheres consisting of Eudragit LIOO-55 and ethyl cellulose prepared by oil-in-oil solvent evaporation method. Ivabradine HCl was encapsulated into microspheres by in situ method. The resultant microspheres were characterized with respect to drug loading, flow properties, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermal analysis and release behavior. Chemical stability of IBH after being encapsulated into microspheres was confirmed by FTR, DSC and XRD. FTIR spectra reflect- ed no interaction between drug and excipients. TGA indicates that prepared microspheres showed much better thermal stability than pure drug ivabradine. SEM images showed formulation of microspheres in spherical shape. The maximum perceniage entrapment efficiency was found to be 81 ± 2.15 and percentage yield was 88 ± 2.65. The maximum in vito drug release was 94.5% for the pH 7.4 and demonstrated that all drug-loaded formulations had a pH-dependent drug release. The cumulative drug release data were analyzed by applying different kinetic models. Korsmeyer-Peppas equation was used to determine value of n which follows non-Fickian diffusion.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29624261

Citation

Majeed, Abdul, et al. "DEVELOPMENT and EVALUATION of IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) and ETHYL CELLULOSE for CONTROLLED DRUG RELEASE." Acta Poloniae Pharmaceutica, vol. 74, no. 2, 2017, pp. 565-578.
Majeed A, Ranjha NM, Hanif M, et al. DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE. Acta Pol Pharm. 2017;74(2):565-578.
Majeed, A., Ranjha, N. M., Hanif, M., Abbas, G., & Khan, M. A. (2017). DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE. Acta Poloniae Pharmaceutica, 74(2), 565-578.
Majeed A, et al. DEVELOPMENT and EVALUATION of IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) and ETHYL CELLULOSE for CONTROLLED DRUG RELEASE. Acta Pol Pharm. 2017;74(2):565-578. PubMed PMID: 29624261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE. AU - Majeed,Abdul, AU - Ranjha,Nazar Muhammad, AU - Hanif,Muhammad, AU - Abbas,Ghulam, AU - Khan,Mahtab Ahmad, PY - 2018/4/7/entrez PY - 2018/4/7/pubmed PY - 2018/5/4/medline SP - 565 EP - 578 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 74 IS - 2 N2 - The objective of this study was to prepare and evaluate ivabradine HCl-loaded microspheres consisting of Eudragit LIOO-55 and ethyl cellulose prepared by oil-in-oil solvent evaporation method. Ivabradine HCl was encapsulated into microspheres by in situ method. The resultant microspheres were characterized with respect to drug loading, flow properties, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermal analysis and release behavior. Chemical stability of IBH after being encapsulated into microspheres was confirmed by FTR, DSC and XRD. FTIR spectra reflect- ed no interaction between drug and excipients. TGA indicates that prepared microspheres showed much better thermal stability than pure drug ivabradine. SEM images showed formulation of microspheres in spherical shape. The maximum perceniage entrapment efficiency was found to be 81 ± 2.15 and percentage yield was 88 ± 2.65. The maximum in vito drug release was 94.5% for the pH 7.4 and demonstrated that all drug-loaded formulations had a pH-dependent drug release. The cumulative drug release data were analyzed by applying different kinetic models. Korsmeyer-Peppas equation was used to determine value of n which follows non-Fickian diffusion. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/29624261/DEVELOPMENT_AND_EVALUATION_OF_IVABRADINE_HCI_LOADED_POLYMERIC_MICROSPHERES_PREPARED_WITH_EUDRAGIT_L100_55__METHACRYLIC_ACID_ETHYL_ACRYLATE_COPOLYMER__AND_ETHYL_CELLULOSE_FOR_CONTROLLED_DRUG_RELEASE_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2017/2/565.pdf DB - PRIME DP - Unbound Medicine ER -