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Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls.
J Neurol Sci 2018; 388:203-207JN

Abstract

INTRODUCTION

LRRK2 G2019S mutation carriers with Parkinson's disease (PD) have been generally indistinguishable from those with idiopathic PD, with the exception of variable differences in some motor and non-motor domains, including cognition, gait, and balance. LRRK2 G2019S is amongst the most common genetic etiologies for PD, particularly in Ashkenazi Jewish (AJ) populations.

METHODS

This cross-sectional data collection study sought to clarify the phenotype of LRRK2 G2019S mutation carriers with PD. Primary endpoints were the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) and Montreal Cognitive Assessment (MoCA). Other motor and non-motor data were also assessed. The Mann-Whitney U Test was utilized to compare LRRK2 G2019S carriers with PD (LRRK2+) with non-carrier PD controls who were matched for age, gender, education, and PD duration. Survival analyses and log rank tests were utilized to compare interval from onset of PD to development of motor and non-motor complications.

RESULTS

We screened 251 subjects and 231 completed the study, of whom 9 were LRRK2+, including 7 AJ subjects. 22.73% of AJ subjects with a family history of PD (FH) and 12.96% of AJ subjects without a FH were LRRK2+. There were no significant differences between the 9 LRRK2+ subjects and 19 matched PD controls in MDS-UPDRS, MoCA, or other motor and non-motor endpoints.

CONCLUSION

Prevalence of the LRRK2 G2019S mutation in AJ and non-AJ subjects in our study population in Cleveland, Ohio was comparable to other clinical studies. There were no significant motor or non-motor differences between LRRK2+ PD and matched PD controls.

Authors+Show Affiliations

Parkinson's and Movement Disorders Center, Neurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, HAN5040, Cleveland, OH 44106, USA. Electronic address: Steven.Gunzler@UHhospitals.org.InMotion, 4829 Galaxy Parkway, Suite M, Warrensville Heights, OH 44128, USA.Department of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: shu.chen@case.edu.Biostatistics, Neurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, HAN5040, Cleveland, OH 44106, USA. Electronic address: curtis.tatsuoka@case.edu.Department of Ophthalmology, Duke University School of Medicine, 2608 Erwin Rd, Durham, NC 27705, USA. Electronic address: will.m.johnson@duke.edu.Department of Pharmacology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: jjm5@cwru.edu.Parkinson's and Movement Disorders Center, Neurological Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, HAN5040, Cleveland, OH 44106, USA. Electronic address: Ellen.Walter@UHhospitals.org.Parkinson's and Movement Disorders Center, Neurological Institute, University Hospitals Cleveland Medical Center (retired), 11100 Euclid Avenue, HAN5040, Cleveland, OH 44106, USA.Epidemiology & Biostatistics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: ixf34@case.edu.Department of Internal Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA. Electronic address: howusudapaah@metrohealth.org.Neurology, Columbia Asia Hospitals, Sarjapur Road, Bangalore 560035, India.Department of Pharmacology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: axw41@case.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29627023

Citation

Gunzler, Steven A., et al. "Motor and Non-motor Features of Parkinson's Disease in LRRK2 G2019S Carriers Versus Matched Controls." Journal of the Neurological Sciences, vol. 388, 2018, pp. 203-207.
Gunzler SA, Riley DE, Chen SG, et al. Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls. J Neurol Sci. 2018;388:203-207.
Gunzler, S. A., Riley, D. E., Chen, S. G., Tatsuoka, C. M., Johnson, W. M., Mieyal, J. J., ... Wilson-Delfosse, A. L. (2018). Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls. Journal of the Neurological Sciences, 388, pp. 203-207. doi:10.1016/j.jns.2018.03.025.
Gunzler SA, et al. Motor and Non-motor Features of Parkinson's Disease in LRRK2 G2019S Carriers Versus Matched Controls. J Neurol Sci. 2018 05 15;388:203-207. PubMed PMID: 29627023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls. AU - Gunzler,Steven A, AU - Riley,David E, AU - Chen,Shu G, AU - Tatsuoka,Curtis M, AU - Johnson,William M, AU - Mieyal,John J, AU - Walter,Ellen M, AU - Whitney,Christina M, AU - Feng,I Jung, AU - Owusu-Dapaah,Harry, AU - Mittal,Shivam O, AU - Wilson-Delfosse,Amy L, Y1 - 2018/03/17/ PY - 2017/12/20/received PY - 2018/02/04/revised PY - 2018/03/14/accepted PY - 2018/4/9/entrez PY - 2018/4/9/pubmed PY - 2019/7/2/medline KW - Autosomal dominant KW - Cognition KW - Leucine-rich repeat kinase KW - Motor features KW - Non-motor features KW - Parkinson's disease SP - 203 EP - 207 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 388 N2 - INTRODUCTION: LRRK2 G2019S mutation carriers with Parkinson's disease (PD) have been generally indistinguishable from those with idiopathic PD, with the exception of variable differences in some motor and non-motor domains, including cognition, gait, and balance. LRRK2 G2019S is amongst the most common genetic etiologies for PD, particularly in Ashkenazi Jewish (AJ) populations. METHODS: This cross-sectional data collection study sought to clarify the phenotype of LRRK2 G2019S mutation carriers with PD. Primary endpoints were the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) and Montreal Cognitive Assessment (MoCA). Other motor and non-motor data were also assessed. The Mann-Whitney U Test was utilized to compare LRRK2 G2019S carriers with PD (LRRK2+) with non-carrier PD controls who were matched for age, gender, education, and PD duration. Survival analyses and log rank tests were utilized to compare interval from onset of PD to development of motor and non-motor complications. RESULTS: We screened 251 subjects and 231 completed the study, of whom 9 were LRRK2+, including 7 AJ subjects. 22.73% of AJ subjects with a family history of PD (FH) and 12.96% of AJ subjects without a FH were LRRK2+. There were no significant differences between the 9 LRRK2+ subjects and 19 matched PD controls in MDS-UPDRS, MoCA, or other motor and non-motor endpoints. CONCLUSION: Prevalence of the LRRK2 G2019S mutation in AJ and non-AJ subjects in our study population in Cleveland, Ohio was comparable to other clinical studies. There were no significant motor or non-motor differences between LRRK2+ PD and matched PD controls. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/29627023/Motor_and_non_motor_features_of_Parkinson's_disease_in_LRRK2_G2019S_carriers_versus_matched_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(18)30150-3 DB - PRIME DP - Unbound Medicine ER -