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Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 08; 126(2):142-151.OS

Abstract

OBJECTIVE

The aim of this study was to measure T helper (Th) 1/Th2-related cytokine expression in saliva from patients with oral lichen planus (OLP), compared with healthy controls (HC group) and controls with recurrent aphthous ulcers (RAU group).

STUDY DESIGN

Saliva was collected from 41 patients with OLP, 14 HCs, and 14 controls with RAU for Th1/Th2-related cytokines analysis with cytometric bead array. Disease activity in OLP was recorded by reticulation/keratosis, erythema, and ulceration scores.

RESULTS

Interleukin (IL)-6, IL-10, interferon-γ (IFN-γ), and IFN-γ/IL-4 in saliva were significantly higher in the OLP group than in the HC group. A positive and significant correlation among IL-6, IL-10, and reticulation/keratosis, erythema, and ulceration scores in the OLP group was revealed. Significantly increased IL-4, IL-5, IL-6, IL-10, tumor necrosis factor-α and IFN-γ/IL-4 were found in the RAU group.

CONCLUSIONS

Salivary cytokine profiles analyzed by cytometric bead array may provide a convenient research approach to OLP. Data indicated complicated Th1/Th2-related cytokine profile changes, rather than simple dominance model, in OLP. IL-10 and especially IL-6 may provide a surrogate endpoint for monitoring OLP.

Authors+Show Affiliations

Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.Department of Immunology, Institutes of Medical Sciences, Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address: Tanggy@shsmu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29627199

Citation

Wei, Wei, et al. "Mixed and Inhomogeneous Expression Profile of Th1/Th2 Related Cytokines Detected By Cytometric Bead Array in the Saliva of Patients With Oral Lichen Planus." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 126, no. 2, 2018, pp. 142-151.
Wei W, Sun Q, Deng Y, et al. Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(2):142-151.
Wei, W., Sun, Q., Deng, Y., Wang, Y., Du, G., Song, C., Li, C., Zhu, M., Chen, G., & Tang, G. (2018). Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(2), 142-151. https://doi.org/10.1016/j.oooo.2018.02.013
Wei W, et al. Mixed and Inhomogeneous Expression Profile of Th1/Th2 Related Cytokines Detected By Cytometric Bead Array in the Saliva of Patients With Oral Lichen Planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(2):142-151. PubMed PMID: 29627199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus. AU - Wei,Wei, AU - Sun,Qianqian, AU - Deng,Yiwen, AU - Wang,Yufeng, AU - Du,Guanhuan, AU - Song,Chencheng, AU - Li,Chenxi, AU - Zhu,Mengxue, AU - Chen,Guangjie, AU - Tang,Guoyao, Y1 - 2018/03/06/ PY - 2017/11/26/received PY - 2018/02/11/revised PY - 2018/02/19/accepted PY - 2018/4/9/pubmed PY - 2018/12/12/medline PY - 2018/4/9/entrez SP - 142 EP - 151 JF - Oral surgery, oral medicine, oral pathology and oral radiology JO - Oral Surg Oral Med Oral Pathol Oral Radiol VL - 126 IS - 2 N2 - OBJECTIVE: The aim of this study was to measure T helper (Th) 1/Th2-related cytokine expression in saliva from patients with oral lichen planus (OLP), compared with healthy controls (HC group) and controls with recurrent aphthous ulcers (RAU group). STUDY DESIGN: Saliva was collected from 41 patients with OLP, 14 HCs, and 14 controls with RAU for Th1/Th2-related cytokines analysis with cytometric bead array. Disease activity in OLP was recorded by reticulation/keratosis, erythema, and ulceration scores. RESULTS: Interleukin (IL)-6, IL-10, interferon-γ (IFN-γ), and IFN-γ/IL-4 in saliva were significantly higher in the OLP group than in the HC group. A positive and significant correlation among IL-6, IL-10, and reticulation/keratosis, erythema, and ulceration scores in the OLP group was revealed. Significantly increased IL-4, IL-5, IL-6, IL-10, tumor necrosis factor-α and IFN-γ/IL-4 were found in the RAU group. CONCLUSIONS: Salivary cytokine profiles analyzed by cytometric bead array may provide a convenient research approach to OLP. Data indicated complicated Th1/Th2-related cytokine profile changes, rather than simple dominance model, in OLP. IL-10 and especially IL-6 may provide a surrogate endpoint for monitoring OLP. SN - 2212-4411 UR - https://www.unboundmedicine.com/medline/citation/29627199/Mixed_and_inhomogeneous_expression_profile_of_Th1/Th2_related_cytokines_detected_by_cytometric_bead_array_in_the_saliva_of_patients_with_oral_lichen_planus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4403(18)30084-1 DB - PRIME DP - Unbound Medicine ER -