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Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis.
Med Mal Infect. 2018 Jun; 48(4):286-290.MM

Abstract

OBJECTIVE

Cerebrospinal fluid (CSF) leukocytes analysis is commonly used to diagnose meningitis and to differentiate bacterial from viral meningitis. Interpreting CSF monocytes can be difficult for physicians, especially in France where lymphocytes and monocytes results are sometimes pooled.

PATIENTS AND METHODS

We assessed SF monocytes in patients presenting with microbiologically confirmed meningitis (CSF leukocyte count>10/mm3 for adults or >30/mm3 for children<2 months), i.e. bacterial meningitis (BM), viral meningitis (VM), and neuroborreliosis (NB).

RESULTS

Two-hundred patients (82 BM, 86 VM, and 32 NB) were included. The proportions of monocytes were higher in VM (median 8%; range 0-57%) than in BM (median 5%; range 0-60%, P=0.03) or NB (median 5%; range 0-53%, P=0.46), with a high value overlap between conditions.

CONCLUSION

CSF monocytes should not be used to discriminate BM from VM and NB because of value overlaps.

Authors+Show Affiliations

Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France. Electronic address: martin.martinot@ch-colmar.fr.Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.Service de microbiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.Service de microbiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.Service de pharmacie, unité de recherche clinique, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29628177

Citation

Martinot, M, et al. "Cerebrospinal Fluid Monocytes in Bacterial Meningitis, Viral Meningitis, and Neuroborreliosis." Medecine Et Maladies Infectieuses, vol. 48, no. 4, 2018, pp. 286-290.
Martinot M, Greigert V, Souply L, et al. Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. Med Mal Infect. 2018;48(4):286-290.
Martinot, M., Greigert, V., Souply, L., Rosolen, B., De Briel, D., Mohseni Zadeh, M., & Kaiser, J. D. (2018). Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. Medecine Et Maladies Infectieuses, 48(4), 286-290. https://doi.org/10.1016/j.medmal.2018.03.002
Martinot M, et al. Cerebrospinal Fluid Monocytes in Bacterial Meningitis, Viral Meningitis, and Neuroborreliosis. Med Mal Infect. 2018;48(4):286-290. PubMed PMID: 29628177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. AU - Martinot,M, AU - Greigert,V, AU - Souply,L, AU - Rosolen,B, AU - De Briel,D, AU - Mohseni Zadeh,M, AU - Kaiser,J-D, Y1 - 2018/04/05/ PY - 2017/07/15/received PY - 2017/08/11/revised PY - 2018/03/08/accepted PY - 2018/4/10/pubmed PY - 2019/6/18/medline PY - 2018/4/10/entrez KW - CSF leukocytes KW - CSF monocytes KW - Leucocytorachie KW - Meningitis KW - Monocytes KW - Méningite SP - 286 EP - 290 JF - Medecine et maladies infectieuses JO - Med Mal Infect VL - 48 IS - 4 N2 - OBJECTIVE: Cerebrospinal fluid (CSF) leukocytes analysis is commonly used to diagnose meningitis and to differentiate bacterial from viral meningitis. Interpreting CSF monocytes can be difficult for physicians, especially in France where lymphocytes and monocytes results are sometimes pooled. PATIENTS AND METHODS: We assessed SF monocytes in patients presenting with microbiologically confirmed meningitis (CSF leukocyte count>10/mm3 for adults or >30/mm3 for children<2 months), i.e. bacterial meningitis (BM), viral meningitis (VM), and neuroborreliosis (NB). RESULTS: Two-hundred patients (82 BM, 86 VM, and 32 NB) were included. The proportions of monocytes were higher in VM (median 8%; range 0-57%) than in BM (median 5%; range 0-60%, P=0.03) or NB (median 5%; range 0-53%, P=0.46), with a high value overlap between conditions. CONCLUSION: CSF monocytes should not be used to discriminate BM from VM and NB because of value overlaps. SN - 1769-6690 UR - https://www.unboundmedicine.com/medline/citation/29628177/Cerebrospinal_fluid_monocytes_in_bacterial_meningitis_viral_meningitis_and_neuroborreliosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-077X(17)30727-8 DB - PRIME DP - Unbound Medicine ER -