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Comparison of Prophylactic Intravenous Magnesium Sulfate with Tramadol for Postspinal Shivering in Elective Cesarean Section: A Placebo Controlled Randomized Double-blind Pilot Study.
Anesth Essays Res. 2018 Jan-Mar; 12(1):130-134.AE

Abstract

Background and Aims

Cesarean sections are performed mostly under spinal anesthesia. Shivering is one of the distressing complications. The aim of the study was to compare the efficacy of intravenous (i.v) magnesium sulfate and tramadol with placebo (normal saline) on postspinal shivering in elective cesarean section when used as prophylaxis.

Methods

One hundred and thirty-five pregnant women between 18 and 35 years age, belonging to the American Society of Anesthesiologists' physical Status II, undergoing elective cesarean section under spinal anesthesia were enrolled into the study. Patients belonging to Group C (control group, n = 45) received isotonic saline 100 mL i.v, Group T (tramadol group, n = 45) received tramadol 0.5 mg/kg in 100 mL isotonic saline i.v, whereas those in Group M (magnesium sulfate group, n = 45) received magnesium sulfate 30 mg/kg in 100 mL isotonic saline i.v after administering spinal anesthesia. Incidence and grades of shivering were noted. Data were analyzed using one-way ANOVA test and Chi-square test.

Results

The incidence of shivering in Group C, Group T, and Group M were 67.5%, 43.9%, and 39%, respectively. The incidence of shivering in Group M and Group T was significantly low when compared to Group C (P = 0.008; P = 0.026), whereas there was no statistically significant difference between Groups T and M (P = 0.654).

Conclusion

Magnesium sulfate and tramadol significantly reduce the incidence of shivering compared to placebo when used as prophylaxis in pregnant women undergoing cesarean section under spinal anesthesia. Magnesium sulfate reduces the severity of the shivering.

Authors+Show Affiliations

Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.Department of Anaesthesiology, DIMHANS and Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.Department of Anaesthesiology, DIMHANS and Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29628568

Citation

Sachidananda, Roopa, et al. "Comparison of Prophylactic Intravenous Magnesium Sulfate With Tramadol for Postspinal Shivering in Elective Cesarean Section: a Placebo Controlled Randomized Double-blind Pilot Study." Anesthesia, Essays and Researches, vol. 12, no. 1, 2018, pp. 130-134.
Sachidananda R, Basavaraj K, Shaikh SI, et al. Comparison of Prophylactic Intravenous Magnesium Sulfate with Tramadol for Postspinal Shivering in Elective Cesarean Section: A Placebo Controlled Randomized Double-blind Pilot Study. Anesthesia, essays and researches. 2018;12(1):130-134.
Sachidananda, R., Basavaraj, K., Shaikh, S. I., Umesh, G., Bhat, T., & Arpitha, B. (2018). Comparison of Prophylactic Intravenous Magnesium Sulfate with Tramadol for Postspinal Shivering in Elective Cesarean Section: A Placebo Controlled Randomized Double-blind Pilot Study. Anesthesia, Essays and Researches, 12(1), 130-134. https://doi.org/10.4103/aer.AER_196_17
Sachidananda R, et al. Comparison of Prophylactic Intravenous Magnesium Sulfate With Tramadol for Postspinal Shivering in Elective Cesarean Section: a Placebo Controlled Randomized Double-blind Pilot Study. Anesthesia, essays and researches. 2018 Jan-Mar;12(1):130-134. PubMed PMID: 29628568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Prophylactic Intravenous Magnesium Sulfate with Tramadol for Postspinal Shivering in Elective Cesarean Section: A Placebo Controlled Randomized Double-blind Pilot Study. AU - Sachidananda,Roopa, AU - Basavaraj,K, AU - Shaikh,Safiya I, AU - Umesh,G, AU - Bhat,Triveni, AU - Arpitha,B, PY - 2018/4/10/entrez PY - 2018/4/10/pubmed PY - 2018/4/10/medline KW - Cesarean section KW - magnesium sulfate KW - shivering KW - tramadol SP - 130 EP - 134 JF - Anesthesia, essays and researches VL - 12 IS - 1 N2 - Background and Aims: Cesarean sections are performed mostly under spinal anesthesia. Shivering is one of the distressing complications. The aim of the study was to compare the efficacy of intravenous (i.v) magnesium sulfate and tramadol with placebo (normal saline) on postspinal shivering in elective cesarean section when used as prophylaxis. Methods: One hundred and thirty-five pregnant women between 18 and 35 years age, belonging to the American Society of Anesthesiologists' physical Status II, undergoing elective cesarean section under spinal anesthesia were enrolled into the study. Patients belonging to Group C (control group, n = 45) received isotonic saline 100 mL i.v, Group T (tramadol group, n = 45) received tramadol 0.5 mg/kg in 100 mL isotonic saline i.v, whereas those in Group M (magnesium sulfate group, n = 45) received magnesium sulfate 30 mg/kg in 100 mL isotonic saline i.v after administering spinal anesthesia. Incidence and grades of shivering were noted. Data were analyzed using one-way ANOVA test and Chi-square test. Results: The incidence of shivering in Group C, Group T, and Group M were 67.5%, 43.9%, and 39%, respectively. The incidence of shivering in Group M and Group T was significantly low when compared to Group C (P = 0.008; P = 0.026), whereas there was no statistically significant difference between Groups T and M (P = 0.654). Conclusion: Magnesium sulfate and tramadol significantly reduce the incidence of shivering compared to placebo when used as prophylaxis in pregnant women undergoing cesarean section under spinal anesthesia. Magnesium sulfate reduces the severity of the shivering. SN - 0259-1162 UR - https://www.unboundmedicine.com/medline/citation/29628568/Comparison_of_Prophylactic_Intravenous_Magnesium_Sulfate_with_Tramadol_for_Postspinal_Shivering_in_Elective_Cesarean_Section:_A_Placebo_Controlled_Randomized_Double_blind_Pilot_Study_ L2 - http://www.aeronline.org/article.asp?issn=0259-1162;year=2018;volume=12;issue=1;spage=130;epage=134;aulast=Sachidananda DB - PRIME DP - Unbound Medicine ER -
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