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Health-related quality of life in pediatric and adolescent patients with transfusion-dependent β-thalassemia in upper Egypt (single center study).
Health Qual Life Outcomes 2018; 16(1):59HQ

Abstract

BACKGROUND

Thalassemia is a major health problem that disturbs the lifestyle of the affected patient. The aim of this work is to detect the impact of thalassemia on the quality of life regarding physical, social, emotional, psychological scored assessment.

METHODS

A case-control survey was conducted in Minia University children's hospital on 64 patients recruiting pediatric hematology outpatient clinic from July 2014 to February 2017. PedsQL™ 4.0 Generic Core Scale (Arabic version) was used to assess HRQOL in 64 thalassemia patients between 8 and 18 years of ages. Other related clinical data of the involved patients were collected from the pediatric hematology records.

RESULTS

Mean physical, emotional, social, school performance, psychological and total scores (- 36.9 ± 20.9, 49.4 ± 17, 47.2 ± 21.3, 38.5 ± 15.5, 45.3 ± 13.8, 47.9 ± 38.8 respectively) were significantly decreased compared with control (p = 0.001 for all). The younger age group had better scores regarding social, emotional, psychological and total scores compared to older ones (p = 0.01, 0.03, 0.01 and 0.009 respectively). Older age of starting transfusion was statistically significant protecting factor from poor physical QOL in thalassemia patients (OR = 0.96, p = 0.03). The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR = 8.5, p = 0.02). Household income was the statistically significant predictor for poor emotional QOL (OR = 5.03, p = 0.04). High serum ferritin was the statistically significant predictor for poor social QOL (OR = 1.1, CI 95%=, p = 0.04). Regarding poor psychological QOL (OR = 0.94, p = 0.01) and total QOL (OR = 0.94, p = 0.01) scores, older age of starting transfusion was the statistically significant protecting factor.

CONCLUSION

Scheduled programs giving psychosocial help and a network connecting between the patients, school officials, thalassemia caregivers and the physician is required especially in developing countries where the health services are not integrated with social organizations. Special school services for thalassemia patients are required to deal with the repeated absence and anemia induced low mental performance of thalassemia children.

Authors+Show Affiliations

Pediatric Department, Faculty of Medicine, Minia University, El Minya, 61511, Egypt. gehanlotfy72@yahoo.com.Pediatric Department, Faculty of Medicine, Minia University, El Minya, 61511, Egypt.Pediatric Department, Faculty of Medicine, Minia University, El Minya, 61511, Egypt.Pediatric Department, Faculty of Medicine, Minia University, El Minya, 61511, Egypt.Public health, Faculty of Medicine, Minia University, Minia, 61511, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29631616

Citation

Hakeem, Gehan L Abdel, et al. "Health-related Quality of Life in Pediatric and Adolescent Patients With Transfusion-dependent SS-thalassemia in Upper Egypt (single Center Study)." Health and Quality of Life Outcomes, vol. 16, no. 1, 2018, p. 59.
Hakeem GLA, Mousa SO, Moustafa AN, et al. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent β-thalassemia in upper Egypt (single center study). Health Qual Life Outcomes. 2018;16(1):59.
Hakeem, G. L. A., Mousa, S. O., Moustafa, A. N., Mahgoob, M. H., & Hassan, E. E. (2018). Health-related quality of life in pediatric and adolescent patients with transfusion-dependent β-thalassemia in upper Egypt (single center study). Health and Quality of Life Outcomes, 16(1), p. 59. doi:10.1186/s12955-018-0893-z.
Hakeem GLA, et al. Health-related Quality of Life in Pediatric and Adolescent Patients With Transfusion-dependent SS-thalassemia in Upper Egypt (single Center Study). Health Qual Life Outcomes. 2018 Apr 10;16(1):59. PubMed PMID: 29631616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life in pediatric and adolescent patients with transfusion-dependent β-thalassemia in upper Egypt (single center study). AU - Hakeem,Gehan L Abdel, AU - Mousa,Suzan O, AU - Moustafa,Asmaa N, AU - Mahgoob,Mohamed H, AU - Hassan,Ebtesam E, Y1 - 2018/04/10/ PY - 2017/02/18/received PY - 2018/04/05/accepted PY - 2018/4/11/entrez PY - 2018/4/11/pubmed PY - 2018/8/10/medline SP - 59 EP - 59 JF - Health and quality of life outcomes JO - Health Qual Life Outcomes VL - 16 IS - 1 N2 - BACKGROUND: Thalassemia is a major health problem that disturbs the lifestyle of the affected patient. The aim of this work is to detect the impact of thalassemia on the quality of life regarding physical, social, emotional, psychological scored assessment. METHODS: A case-control survey was conducted in Minia University children's hospital on 64 patients recruiting pediatric hematology outpatient clinic from July 2014 to February 2017. PedsQL™ 4.0 Generic Core Scale (Arabic version) was used to assess HRQOL in 64 thalassemia patients between 8 and 18 years of ages. Other related clinical data of the involved patients were collected from the pediatric hematology records. RESULTS: Mean physical, emotional, social, school performance, psychological and total scores (- 36.9 ± 20.9, 49.4 ± 17, 47.2 ± 21.3, 38.5 ± 15.5, 45.3 ± 13.8, 47.9 ± 38.8 respectively) were significantly decreased compared with control (p = 0.001 for all). The younger age group had better scores regarding social, emotional, psychological and total scores compared to older ones (p = 0.01, 0.03, 0.01 and 0.009 respectively). Older age of starting transfusion was statistically significant protecting factor from poor physical QOL in thalassemia patients (OR = 0.96, p = 0.03). The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR = 8.5, p = 0.02). Household income was the statistically significant predictor for poor emotional QOL (OR = 5.03, p = 0.04). High serum ferritin was the statistically significant predictor for poor social QOL (OR = 1.1, CI 95%=, p = 0.04). Regarding poor psychological QOL (OR = 0.94, p = 0.01) and total QOL (OR = 0.94, p = 0.01) scores, older age of starting transfusion was the statistically significant protecting factor. CONCLUSION: Scheduled programs giving psychosocial help and a network connecting between the patients, school officials, thalassemia caregivers and the physician is required especially in developing countries where the health services are not integrated with social organizations. Special school services for thalassemia patients are required to deal with the repeated absence and anemia induced low mental performance of thalassemia children. SN - 1477-7525 UR - https://www.unboundmedicine.com/medline/citation/29631616/Health_related_quality_of_life_in_pediatric_and_adolescent_patients_with_transfusion_dependent_β_thalassemia_in_upper_Egypt__single_center_study__ L2 - https://hqlo.biomedcentral.com/articles/10.1186/s12955-018-0893-z DB - PRIME DP - Unbound Medicine ER -