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Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
J Eur Acad Dermatol Venereol 2018; 32(7):1214-1221JE

Abstract

BACKGROUND

Alopecia areata (AA) is a hair follicle-specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency.

OBJECTIVE

To demonstrate the differences of the mean serum 25-hydroxyvitamin D level and prevalence of vitamin D deficiency between AA patients and non-AA population.

METHODS

A systematic review and meta-analysis of observational studies on AA and serum vitamin D levels and/or prevalence of vitamin D deficiency was performed searching MEDLINE, Cochrane, Web of Science and Google Scholar databases.

RESULTS

In all, 14 studies including a total of 1255 AA subjects and 784 non-AA control were analysed. The mean serum 25-hydroxyvitamin D level was significantly lower in AA subjects (-8.52 ng/dL; 95% confidential interval; -5.50 to -11.53). The AA subjects had higher odds of vitamin D deficiency (odds ratio of 3.89; 2.02 to 7.49, mean prevalence of 73.8%; 59.1 to 84.6%). However, it was difficult to find clear correlation between serum 25-hydroxyvitamin D level and extent of hair loss in AA subjects.

CONCLUSION

The AA subjects had lower serum 25-hydroxyvitamin D level, and vitamin D deficiency was highly prevalent compared to non-AA controls. Hence, vitamin D deficiency should be assessed in AA patients. Furthermore, nutritional supplementation of vitamin D or topical vitamin D analogues can be considered for AA patients with vitamin D deficiency. The limitation of this study is the highly heterogeneity of the included studies.

Authors+Show Affiliations

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

29633370

Citation

Lee, S, et al. "Increased Prevalence of Vitamin D Deficiency in Patients With Alopecia Areata: a Systematic Review and Meta-analysis." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 32, no. 7, 2018, pp. 1214-1221.
Lee S, Kim BJ, Lee CH, et al. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(7):1214-1221.
Lee, S., Kim, B. J., Lee, C. H., & Lee, W. S. (2018). Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology : JEADV, 32(7), pp. 1214-1221. doi:10.1111/jdv.14987.
Lee S, et al. Increased Prevalence of Vitamin D Deficiency in Patients With Alopecia Areata: a Systematic Review and Meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(7):1214-1221. PubMed PMID: 29633370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. AU - Lee,S, AU - Kim,B J, AU - Lee,C H, AU - Lee,W S, Y1 - 2018/05/18/ PY - 2017/12/01/received PY - 2018/03/22/accepted PY - 2018/4/11/pubmed PY - 2018/12/12/medline PY - 2018/4/11/entrez SP - 1214 EP - 1221 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 32 IS - 7 N2 - BACKGROUND: Alopecia areata (AA) is a hair follicle-specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency. OBJECTIVE: To demonstrate the differences of the mean serum 25-hydroxyvitamin D level and prevalence of vitamin D deficiency between AA patients and non-AA population. METHODS: A systematic review and meta-analysis of observational studies on AA and serum vitamin D levels and/or prevalence of vitamin D deficiency was performed searching MEDLINE, Cochrane, Web of Science and Google Scholar databases. RESULTS: In all, 14 studies including a total of 1255 AA subjects and 784 non-AA control were analysed. The mean serum 25-hydroxyvitamin D level was significantly lower in AA subjects (-8.52 ng/dL; 95% confidential interval; -5.50 to -11.53). The AA subjects had higher odds of vitamin D deficiency (odds ratio of 3.89; 2.02 to 7.49, mean prevalence of 73.8%; 59.1 to 84.6%). However, it was difficult to find clear correlation between serum 25-hydroxyvitamin D level and extent of hair loss in AA subjects. CONCLUSION: The AA subjects had lower serum 25-hydroxyvitamin D level, and vitamin D deficiency was highly prevalent compared to non-AA controls. Hence, vitamin D deficiency should be assessed in AA patients. Furthermore, nutritional supplementation of vitamin D or topical vitamin D analogues can be considered for AA patients with vitamin D deficiency. The limitation of this study is the highly heterogeneity of the included studies. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/29633370/Increased_prevalence_of_vitamin_D_deficiency_in_patients_with_alopecia_areata:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/jdv.14987 DB - PRIME DP - Unbound Medicine ER -