Tags

Type your tag names separated by a space and hit enter

Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study.
Arch Ital Urol Androl. 2018 Mar 31; 90(1):25-28.AI

Abstract

PURPOSE

In this study, we compared the effects of three agents frequently used in daily life for medical expulsive therapy.

MATERIALS AND METHODS

A total of 143 patients meeting the criteria were included in the study. Patients were divided into three homogeneous drug groups which were tamsulosin group (n:48), alfuzosin group (n:47) and silodosin group (n:48). The time of stone expulsion, analgesic needs, side effects of the medicine and endoscopic intervention needs of the patients were recorded.

RESULTS

The rate of stone expulsion was 70.8% (n:34) in tamsulosin group, 70.2% (n:33) in alfuzosin group, and 75% (n:36) in silodosin group. No significant difference was observed among the rates of stone expulsion in three groups, and the rates of stone expulsion were similar (p = 0.778). The duration of stone expulsion was significantly different in the groups (p = 0.012): the time of stone expulsion for tamsulosin was 2.33 ± 0.78 days longer than for Silodosin, indicating a significant difference. There was no significant difference between tamsulosin-alfuzosin and silodosin-alfuzosin (respectively p = 0.147, p = 0.925).

CONCLUSIONS

The results of this study showed that medical expulsive therapy by using alpha blocker agents is safe and efficacious. This option must be kept in mind for patients who do not ask for surgery as the first-step treatment for eligible patients.

Authors+Show Affiliations

Hitit University Corum Training and Research Hospital. aykutbugra@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Observational Study

Language

eng

PubMed ID

29633795

Citation

Sentürk, Aykut Buğra, et al. "Comparison of Three Most Frequently Used Alpha Blocker Agents in Medical Expulsive Therapy for Distal Ureteral Calculi, Result of a Retrospective Observational Study." Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [di] Societa Italiana Di Ecografia Urologica E Nefrologica, vol. 90, no. 1, 2018, pp. 25-28.
Sentürk AB, Aydin C, Ekici M, et al. Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study. Arch Ital Urol Androl. 2018;90(1):25-28.
Sentürk, A. B., Aydin, C., Ekici, M., Yaytokgil, M., Akkoc, A., & Baykam, M. M. (2018). Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study. Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [di] Societa Italiana Di Ecografia Urologica E Nefrologica, 90(1), 25-28. https://doi.org/10.4081/aiua.2018.1.25
Sentürk AB, et al. Comparison of Three Most Frequently Used Alpha Blocker Agents in Medical Expulsive Therapy for Distal Ureteral Calculi, Result of a Retrospective Observational Study. Arch Ital Urol Androl. 2018 Mar 31;90(1):25-28. PubMed PMID: 29633795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of three most frequently used alpha blocker agents in medical expulsive therapy for distal ureteral calculi, result of a retrospective observational study. AU - Sentürk,Aykut Buğra, AU - Aydin,Cemil, AU - Ekici,Musa, AU - Yaytokgil,Muhammet, AU - Akkoc,Ali, AU - Baykam,Mehmet Murat, Y1 - 2018/03/31/ PY - 2018/02/13/received PY - 2018/02/24/accepted PY - 2018/4/11/entrez PY - 2018/4/11/pubmed PY - 2019/9/3/medline KW - Stone KW - Ureter KW - Urology SP - 25 EP - 28 JF - Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica JO - Arch Ital Urol Androl VL - 90 IS - 1 N2 - PURPOSE: In this study, we compared the effects of three agents frequently used in daily life for medical expulsive therapy. MATERIALS AND METHODS: A total of 143 patients meeting the criteria were included in the study. Patients were divided into three homogeneous drug groups which were tamsulosin group (n:48), alfuzosin group (n:47) and silodosin group (n:48). The time of stone expulsion, analgesic needs, side effects of the medicine and endoscopic intervention needs of the patients were recorded. RESULTS: The rate of stone expulsion was 70.8% (n:34) in tamsulosin group, 70.2% (n:33) in alfuzosin group, and 75% (n:36) in silodosin group. No significant difference was observed among the rates of stone expulsion in three groups, and the rates of stone expulsion were similar (p = 0.778). The duration of stone expulsion was significantly different in the groups (p = 0.012): the time of stone expulsion for tamsulosin was 2.33 ± 0.78 days longer than for Silodosin, indicating a significant difference. There was no significant difference between tamsulosin-alfuzosin and silodosin-alfuzosin (respectively p = 0.147, p = 0.925). CONCLUSIONS: The results of this study showed that medical expulsive therapy by using alpha blocker agents is safe and efficacious. This option must be kept in mind for patients who do not ask for surgery as the first-step treatment for eligible patients. SN - 1124-3562 UR - https://www.unboundmedicine.com/medline/citation/29633795/Comparison_of_three_most_frequently_used_alpha_blocker_agents_in_medical_expulsive_therapy_for_distal_ureteral_calculi,_result_of_a_retrospective_observational_study L2 - https://doi.org/10.4081/aiua.2018.1.25 DB - PRIME DP - Unbound Medicine ER -