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Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress.
Oxid Med Cell Longev 2018; 2018:3060525OM

Abstract

Background

The antimicrobial activity of the Equisetum arvense L. extract and the mechanisms involved in the in vitro effects on endothelial vascular cells exposed to hyperosmotic stress were evaluated.

Methods

Antimicrobial activity was evaluated by disk diffusion method and minimum inhibitory concentration (MIC) determination, and oxidative stress, inflammation, and apoptosis, in pretreatment with Equisetum arvense L., caffeic acid, and cathechin, were quantified.

Results

The results have shown that Equisetum arvense L. exhibited antibacterial effects only on pathogenic gram-positive cocci. The modulatory activity of Equisetum arvense L. on endothelial cells exposed to hypertonic medium was different and depended on the concentration used. Low concentrations of tested compounds exerted antioxidant effect and diminished the activity of caspase-8 and also increased IκB expression while in high doses, Equisetum arvense L. was prooxidant, induced apoptosis, and decreased IL-6 secretion.

Conclusions

These experimental findings suggest that Equisetum arvense L. has antibacterial effects on gram-positive cocci and, administered in low dose, may be a new therapeutic approach for diseases associated with hypertonic conditions or oxidative stress and apoptosis.

Links

  • PMC Free PDF
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    ncbi.nlm.nih.gov
    dx.doi.org

    Authors+Show Affiliations

    Pallag A
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, Romania.
    Filip GA
    Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Romania.
    Olteanu D
    Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Romania.
    Clichici S
    Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Romania.
    Baldea I
    Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Romania.
    Jurca T
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, Romania.
    Micle O
    Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piata 1 Decembrie Street, 410073 Oradea, Romania.
    Vicaş L
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, Romania.
    Marian E
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, Romania.
    Soriţău O
    Departments of Radiobiology and Tumor Biology, Oncology Institute "Prof. I. Chiricuta", 34-36 Republicii Street, 400015 Cluj-Napoca, Romania.
    Cenariu M
    Department of Biochemistry, University of Agricultural Sciences and Veterinary Medicine, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.
    Mureşan M
    Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piata 1 Decembrie Street, 410073 Oradea, Romania.

    MeSH

    Anti-Bacterial AgentsApoptosisEndothelial CellsEquisetumInflammationOxidative StressPlant Extracts

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29636839

    Citation

    Pallag, Annamaria, et al. "Equisetum Arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 3060525.
    Pallag A, Filip GA, Olteanu D, et al. Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress. Oxid Med Cell Longev. 2018;2018:3060525.
    Pallag, A., Filip, G. A., Olteanu, D., Clichici, S., Baldea, I., Jurca, T., ... Mureşan, M. (2018). Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress. Oxidative Medicine and Cellular Longevity, 2018, p. 3060525. doi:10.1155/2018/3060525.
    Pallag A, et al. Equisetum Arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress. Oxid Med Cell Longev. 2018;2018:3060525. PubMed PMID: 29636839.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress. AU - Pallag,Annamaria, AU - Filip,Gabriela Adriana, AU - Olteanu,Diana, AU - Clichici,Simona, AU - Baldea,Ioana, AU - Jurca,Tunde, AU - Micle,Otilia, AU - Vicaş,Laura, AU - Marian,Eleonora, AU - Soriţău,Olga, AU - Cenariu,Mihai, AU - Mureşan,Mariana, Y1 - 2018/02/14/ PY - 2017/09/12/received PY - 2017/11/09/revised PY - 2018/01/01/accepted PY - 2018/4/12/entrez PY - 2018/4/11/pubmed PY - 2018/9/6/medline SP - 3060525 EP - 3060525 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - Background: The antimicrobial activity of the Equisetum arvense L. extract and the mechanisms involved in the in vitro effects on endothelial vascular cells exposed to hyperosmotic stress were evaluated. Methods: Antimicrobial activity was evaluated by disk diffusion method and minimum inhibitory concentration (MIC) determination, and oxidative stress, inflammation, and apoptosis, in pretreatment with Equisetum arvense L., caffeic acid, and cathechin, were quantified. Results: The results have shown that Equisetum arvense L. exhibited antibacterial effects only on pathogenic gram-positive cocci. The modulatory activity of Equisetum arvense L. on endothelial cells exposed to hypertonic medium was different and depended on the concentration used. Low concentrations of tested compounds exerted antioxidant effect and diminished the activity of caspase-8 and also increased IκB expression while in high doses, Equisetum arvense L. was prooxidant, induced apoptosis, and decreased IL-6 secretion. Conclusions: These experimental findings suggest that Equisetum arvense L. has antibacterial effects on gram-positive cocci and, administered in low dose, may be a new therapeutic approach for diseases associated with hypertonic conditions or oxidative stress and apoptosis. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29636839/Equisetum_arvense_L__Extract_Induces_Antibacterial_Activity_and_Modulates_Oxidative_Stress_Inflammation_and_Apoptosis_in_Endothelial_Vascular_Cells_Exposed_to_Hyperosmotic_Stress_ L2 - https://dx.doi.org/10.1155/2018/3060525 DB - PRIME DP - Unbound Medicine ER -