TY - JOUR T1 - Clinical profile and outcome of children with scrub typhus from Chennai, South India. AU - Ganesh,Ramaswamy, AU - Suresh,Natarajan, AU - Pratyusha,L L, AU - Janakiraman,Lalitha, AU - Manickam,Mani, AU - Andal,A, Y1 - 2018/04/10/ PY - 2017/05/17/received PY - 2018/04/04/accepted PY - 2018/03/01/revised PY - 2018/4/11/pubmed PY - 2018/9/1/medline PY - 2018/4/12/entrez KW - AST KW - Children KW - Neonates KW - Scrub typhus KW - Thrombocytopenia SP - 887 EP - 890 JF - European journal of pediatrics JO - Eur J Pediatr VL - 177 IS - 6 N2 - : Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. We prospectively studied the clinico-laboratory profile and outcome of 358 children aged 1 day to 18 years diagnosed with scrub typhus from Chennai, South India. All children (100%) had fever. Eschar was seen in 67%. All children were treated with oral doxycycline and those with complications were treated with intravenous chloramphenicol/azithromycin. Rapid defervescence (within 48 h) after initiation of doxycline was seen in 306 (85%) and 52 (14.5%) developed complications. Multivariate logistic regression analysis revealed that children who had an elevated aspartate amino transferase (> 120 IU/L) and the presence of thrombocytopenia (platelet count less than 1 lac cells/mm3) at admission had high risk of developing complications. The overall mortality rate in this series was 0.8%. CONCLUSION: Our 4-year study highlights the clinico-laboratory profile of Scrub typhus in children from Chennai, South India. Early recognition and prompt treatment reduces the complication and mortality. What is Known: • Scrub typhus is endemic to tsutsugamushi triangle, a geographical triangle extending from northern Japan in the east to Pakistan and Afghanistan in the west and northern Australia in the south. • There is paucity of data regarding its clinico-laboratory profile in neonates as well as its predictors of outcome. What is New: • Children who had an elevated AST and the presence of thrombocytopenia at admission had high risk of developing complications. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/29637374/Clinical_profile_and_outcome_of_children_with_scrub_typhus_from_Chennai_South_India_ DB - PRIME DP - Unbound Medicine ER -