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[T lymphocyte subsets in alveolar lavage and peripheral blood in sarcoidosis and extrinsic allergic alveolitis].
Pathol Biol (Paris). 1987 Dec; 35(10):1301-8.PB

Abstract

Accumulation of inflammatory and immune cells within lung parenchyma would constitute the initial step in producing the alveolar structural abnormalities. It is usually assumed that alveolitis, as assessed by broncho-alveolar lavage (BAL), represents a biological assessment of lung disease activity. The aim of this study, using monoclonal antibodies, is to characterize the T lymphocytes alveolitis in the lung and in peripheral blood in 3 well-defined populations: 1 degree) control subjects (n = 7); 2 degrees) patients with biopsy proven mediastino-pulmonary sarcoidosis (sarc) (n = 73), classified according to their clinical activity as active, inactive, chronic, and treated; 3 degrees) patients with extrinsic alveolar alveolitis (EAA) (n = 19). For the same BAL volume, the % of CD4+ cells and the CD4/CD8 ratio are increased in chronic and active sarc, contrasting with an increase in the % of CD8+ cells and a decrease in the CD4/CD8 ratio in the EAA. In absolute values, there are 2 times as many CD4+ cells and 5 times as many CD8+ cells in EAA than in sarcoidosis. In sarcoidosis, corticotherapy tends to normalize the CD4/CD8 ratio although the intensity of the lymphocytic alveolitis is not affected. In the peripheral blood, lymphopenia is observed only in the active form of sarc. in the CD4+ population, without any significant change in the CD4/CD8 ratio compared to the other groups. The number and distributions of BAL. T lymphocytes subsets may constitute a biological indicator for diagnostic orientation, but they do not distinguish sufficiently between the different groups of sarcoidosis to be of any prognostic value.

Authors+Show Affiliations

Service de Pneumologie, Hôpital Pontchaillou, Centre Hospitalier Régional de Rennes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

2963992

Citation

Desrues, B, et al. "[T Lymphocyte Subsets in Alveolar Lavage and Peripheral Blood in Sarcoidosis and Extrinsic Allergic Alveolitis]." Pathologie-biologie, vol. 35, no. 10, 1987, pp. 1301-8.
Desrues B, Delaval P, Genetet N, et al. [T lymphocyte subsets in alveolar lavage and peripheral blood in sarcoidosis and extrinsic allergic alveolitis]. Pathol Biol (Paris). 1987;35(10):1301-8.
Desrues, B., Delaval, P., Genetet, N., Kernec, J., Pencolé, C., Merdrignac, G., Cornillet, B., & Genetet, B. (1987). [T lymphocyte subsets in alveolar lavage and peripheral blood in sarcoidosis and extrinsic allergic alveolitis]. Pathologie-biologie, 35(10), 1301-8.
Desrues B, et al. [T Lymphocyte Subsets in Alveolar Lavage and Peripheral Blood in Sarcoidosis and Extrinsic Allergic Alveolitis]. Pathol Biol (Paris). 1987;35(10):1301-8. PubMed PMID: 2963992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [T lymphocyte subsets in alveolar lavage and peripheral blood in sarcoidosis and extrinsic allergic alveolitis]. AU - Desrues,B, AU - Delaval,P, AU - Genetet,N, AU - Kernec,J, AU - Pencolé,C, AU - Merdrignac,G, AU - Cornillet,B, AU - Genetet,B, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 1301 EP - 8 JF - Pathologie-biologie JO - Pathol Biol (Paris) VL - 35 IS - 10 N2 - Accumulation of inflammatory and immune cells within lung parenchyma would constitute the initial step in producing the alveolar structural abnormalities. It is usually assumed that alveolitis, as assessed by broncho-alveolar lavage (BAL), represents a biological assessment of lung disease activity. The aim of this study, using monoclonal antibodies, is to characterize the T lymphocytes alveolitis in the lung and in peripheral blood in 3 well-defined populations: 1 degree) control subjects (n = 7); 2 degrees) patients with biopsy proven mediastino-pulmonary sarcoidosis (sarc) (n = 73), classified according to their clinical activity as active, inactive, chronic, and treated; 3 degrees) patients with extrinsic alveolar alveolitis (EAA) (n = 19). For the same BAL volume, the % of CD4+ cells and the CD4/CD8 ratio are increased in chronic and active sarc, contrasting with an increase in the % of CD8+ cells and a decrease in the CD4/CD8 ratio in the EAA. In absolute values, there are 2 times as many CD4+ cells and 5 times as many CD8+ cells in EAA than in sarcoidosis. In sarcoidosis, corticotherapy tends to normalize the CD4/CD8 ratio although the intensity of the lymphocytic alveolitis is not affected. In the peripheral blood, lymphopenia is observed only in the active form of sarc. in the CD4+ population, without any significant change in the CD4/CD8 ratio compared to the other groups. The number and distributions of BAL. T lymphocytes subsets may constitute a biological indicator for diagnostic orientation, but they do not distinguish sufficiently between the different groups of sarcoidosis to be of any prognostic value. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/2963992/[T_lymphocyte_subsets_in_alveolar_lavage_and_peripheral_blood_in_sarcoidosis_and_extrinsic_allergic_alveolitis]_ L2 - http://www.diseaseinfosearch.org/result/6412 DB - PRIME DP - Unbound Medicine ER -