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Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study.

Abstract

Lung cancer in men and breast cancer in women are the most commonly diagnosed cancers in Poland and worldwide. Results of studies involving dietary patterns (DPs) and breast or lung cancer risk in European countries outside the Mediterranean Sea region are limited and inconclusive. This study aimed to develop a 'Polish-adapted Mediterranean Diet' ('Polish-aMED') score, and then study the associations between the 'Polish-aMED' score and a posteriori-derived dietary patterns with breast or lung cancer risk in adult Poles. This pooled analysis of two case-control studies involved 560 subjects (280 men, 280 women) aged 40-75 years from Northeastern Poland. Diagnoses of breast cancer in 140 women and lung cancer in 140 men were found. The food frequency consumption of 21 selected food groups was collected using a 62-item Food Frequency Questionnaire (FFQ)-6. The 'Polish-adapted Mediterranean Diet' score which included eight items-vegetables, fruit, whole grain, fish, legumes, nuts and seeds-as well as the ratio of vegetable oils to animal fat and red and processed meat was developed (range: 0-8 points). Three DPs were identified in a Principal Component Analysis: 'Prudent', 'Non-healthy', 'Dressings and sweetened-low-fat dairy'. In a multiple logistic regression analysis, two models were created: crude, and adjusted for age, sex, type of cancer, Body Mass Index (BMI), socioeconomic status (SES) index, overall physical activity, smoking status and alcohol abuse. The risk of breast or lung cancer was lower in the average (3-5 points) and high (6-8 points) levels of the 'Polish-aMED' score compared to the low (0-2 points) level by 51% (odds ratio (OR): 0.49; 95% confidence interval (Cl): 0.30-0.80; p < 0.01; adjusted) and 63% (OR: 0.37; 95% Cl: 0.21-0.64; p < 0.001; adjusted), respectively. In the middle and upper tertiles compared to the bottom tertile of the 'Prudent' DP, the risk of cancer was lower by 38-43% (crude) but was not significant after adjustment for confounders. In the upper compared to the bottom tertile of the 'Non-healthy' DP, the risk of cancer was higher by 65% (OR: 1.65; 95% Cl: 1.05-2.59; p < 0.05; adjusted). In conclusion, the Polish adaptation of the Mediterranean diet could be considered for adults living in non-Mediterranean countries for the prevention of the breast or lung cancers. Future studies should explore the role of a traditional Mediterranean diet fitted to local dietary patterns of non-Mediterranean Europeans in cancer prevention.

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  • Authors+Show Affiliations

    ,

    Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland. beata.krusinska@uwm.edu.pl.

    ,

    Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland. iwona.hawrysz@uwm.edu.pl.

    ,

    Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland. lidia.wadolowska@uwm.edu.pl.

    ,

    Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland. malgorzata.slowinska@uwm.edu.pl.

    ,

    Department of Surgery, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, Poland. maciej.biernacki@uwm.edu.pl.

    ,

    Independent Public Complex of Tuberculosis and Lung Diseases in Olsztyn, 10-357 Olsztyn, Poland. aczerwinska@pulmonologia.olsztyn.pl.

    Clinic of Thoracic Surgery, Medical Center Ars Medica, 10-513 Olsztyn, Poland. januszgolota@vp.pl.

    Source

    Nutrients 10:4 2018 Apr 11 pg

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Case-Control Studies
    Chi-Square Distribution
    Diet, Mediterranean
    Feeding Behavior
    Female
    Healthy Diet
    Humans
    Logistic Models
    Lung Neoplasms
    Male
    Middle Aged
    Nutritional Status
    Nutritive Value
    Poland
    Principal Component Analysis
    Protective Factors
    Risk Assessment
    Risk Factors
    Risk Reduction Behavior
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29641468

    Citation

    Krusinska, Beata, et al. "Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns With Breast and Lung Cancer Risk: a Case-Control Study." Nutrients, vol. 10, no. 4, 2018.
    Krusinska B, Hawrysz I, Wadolowska L, et al. Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study. Nutrients. 2018;10(4).
    Krusinska, B., Hawrysz, I., Wadolowska, L., Slowinska, M. A., Biernacki, M., Czerwinska, A., & Golota, J. J. (2018). Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study. Nutrients, 10(4), doi:10.3390/nu10040470.
    Krusinska B, et al. Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns With Breast and Lung Cancer Risk: a Case-Control Study. Nutrients. 2018 Apr 11;10(4) PubMed PMID: 29641468.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study. AU - Krusinska,Beata, AU - Hawrysz,Iwona, AU - Wadolowska,Lidia, AU - Slowinska,Malgorzata Anna, AU - Biernacki,Maciej, AU - Czerwinska,Anna, AU - Golota,Janusz Jacek, Y1 - 2018/04/11/ PY - 2018/02/06/received PY - 2018/03/22/revised PY - 2018/04/07/accepted PY - 2018/4/12/entrez PY - 2018/4/12/pubmed PY - 2018/9/18/medline KW - Mediterranean diet KW - adults KW - breast cancer KW - dietary pattern KW - lung cancer JF - Nutrients JO - Nutrients VL - 10 IS - 4 N2 - Lung cancer in men and breast cancer in women are the most commonly diagnosed cancers in Poland and worldwide. Results of studies involving dietary patterns (DPs) and breast or lung cancer risk in European countries outside the Mediterranean Sea region are limited and inconclusive. This study aimed to develop a 'Polish-adapted Mediterranean Diet' ('Polish-aMED') score, and then study the associations between the 'Polish-aMED' score and a posteriori-derived dietary patterns with breast or lung cancer risk in adult Poles. This pooled analysis of two case-control studies involved 560 subjects (280 men, 280 women) aged 40-75 years from Northeastern Poland. Diagnoses of breast cancer in 140 women and lung cancer in 140 men were found. The food frequency consumption of 21 selected food groups was collected using a 62-item Food Frequency Questionnaire (FFQ)-6. The 'Polish-adapted Mediterranean Diet' score which included eight items-vegetables, fruit, whole grain, fish, legumes, nuts and seeds-as well as the ratio of vegetable oils to animal fat and red and processed meat was developed (range: 0-8 points). Three DPs were identified in a Principal Component Analysis: 'Prudent', 'Non-healthy', 'Dressings and sweetened-low-fat dairy'. In a multiple logistic regression analysis, two models were created: crude, and adjusted for age, sex, type of cancer, Body Mass Index (BMI), socioeconomic status (SES) index, overall physical activity, smoking status and alcohol abuse. The risk of breast or lung cancer was lower in the average (3-5 points) and high (6-8 points) levels of the 'Polish-aMED' score compared to the low (0-2 points) level by 51% (odds ratio (OR): 0.49; 95% confidence interval (Cl): 0.30-0.80; p < 0.01; adjusted) and 63% (OR: 0.37; 95% Cl: 0.21-0.64; p < 0.001; adjusted), respectively. In the middle and upper tertiles compared to the bottom tertile of the 'Prudent' DP, the risk of cancer was lower by 38-43% (crude) but was not significant after adjustment for confounders. In the upper compared to the bottom tertile of the 'Non-healthy' DP, the risk of cancer was higher by 65% (OR: 1.65; 95% Cl: 1.05-2.59; p < 0.05; adjusted). In conclusion, the Polish adaptation of the Mediterranean diet could be considered for adults living in non-Mediterranean countries for the prevention of the breast or lung cancers. Future studies should explore the role of a traditional Mediterranean diet fitted to local dietary patterns of non-Mediterranean Europeans in cancer prevention. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29641468/Associations_of_Mediterranean_Diet_and_a_Posteriori_Derived_Dietary_Patterns_with_Breast_and_Lung_Cancer_Risk:_A_Case_Control_Study_ L2 - http://www.mdpi.com/resolver?pii=nu10040470 DB - PRIME DP - Unbound Medicine ER -