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Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases.
An Bras Dermatol 2018 Jan-Feb; 93(1):80-85AB

Abstract

Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by an absence of systemic granulomatous disease, is a diagnosis of exclusion. The main differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however, it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is well documented. Currently, therapeutic options consider restrictive diets, topical, intralesional, and systemic agents. First-line therapy is currently a matter of debate. We present a review of the value of diet therapy in this syndrome, along with two illustrative cases.

Authors+Show Affiliations

Oral Biopsy Service at Dental School, University of Chile - Santiago, Chile.Dermatology Service, Clinics Hospital Dr. Manuel Quintela - University of the Republic - Montevideo, Uruguay.Dermatology Service, Alemana de Santiago Clinic - Santiago, Chile. Dermatology Department, University del Desarrollo - Región del Bío Bío, Chile.Immunology, Allergy and Pediatric Rheumatology, Pontifical Catholic University of Chile - Santiago, Chile.Dermatology Service, Alemana de Santiago Clinic - Santiago, Chile.Department of Oral Pathology and Medicine, University of Chile - Santiago, Chile.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

29641703

Citation

Espinoza, Iris, et al. "Orofacial Granulomatosis and Diet Therapy: a Review of the Literature and Two Clinical Cases." Anais Brasileiros De Dermatologia, vol. 93, no. 1, 2018, pp. 80-85.
Espinoza I, Navarrete J, Benedetto J, et al. Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases. An Bras Dermatol. 2018;93(1):80-85.
Espinoza, I., Navarrete, J., Benedetto, J., Borzutzky, A., Roessler, P., & Ortega-Pinto, A. (2018). Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases. Anais Brasileiros De Dermatologia, 93(1), pp. 80-85. doi:10.1590/abd1806-4841.20185828.
Espinoza I, et al. Orofacial Granulomatosis and Diet Therapy: a Review of the Literature and Two Clinical Cases. An Bras Dermatol. 2018;93(1):80-85. PubMed PMID: 29641703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases. AU - Espinoza,Iris, AU - Navarrete,Jorge, AU - Benedetto,Juana, AU - Borzutzky,Arturo, AU - Roessler,Patricia, AU - Ortega-Pinto,Ana, PY - 2016/03/23/received PY - 2016/08/09/accepted PY - 2018/4/12/entrez PY - 2018/4/12/pubmed PY - 2018/4/25/medline SP - 80 EP - 85 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 93 IS - 1 N2 - Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by an absence of systemic granulomatous disease, is a diagnosis of exclusion. The main differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however, it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is well documented. Currently, therapeutic options consider restrictive diets, topical, intralesional, and systemic agents. First-line therapy is currently a matter of debate. We present a review of the value of diet therapy in this syndrome, along with two illustrative cases. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/29641703/Orofacial_granulomatosis_and_diet_therapy:_a_review_of_the_literature_and_two_clinical_cases_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000100080&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -