Tags

Type your tag names separated by a space and hit enter

Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea.
PLoS One. 2018; 13(4):e0195563.Plos

Abstract

PURPOSE

To investigate the association between oral fluoroquinolones (FQ) and the risk of rhegmatogenous retinal detachment (RRD) using a nationwide population-based study in Korea, designed to control for time-related bias.

METHODS

As a nested case-control study within a cohort, the KNHIS-NSC 2002-2013 (Korean National Health Insurance Service National Sample Cohort) data used for the investigation. The subjects who visited an ophthalmologist were included in a cohort. Subjects with infectious ocular diseases, severe ocular trauma, and congenital diseases were excluded. Within the cohort, subjects who underwent surgery for RRD were defined as cases, and controls were matched by age group, sex, and cohort entry date using an incidence density sampling method. After investigating the exposure to oral FQ, the odds ratio was calculated by the FQ exposure rate of both groups and adjusted by the confounding factors of demography, health service utilization, and comorbidities.

RESULTS

A total of 1,151 subjects in the case group and 11,470 subjects in the control group were included. There were intergroup differences in household income, numbers of ophthalmologic visits and drug prescriptions, events of intraocular surgeries, and prevalence of diabetes and degenerative myopia (all P's<0.05). The crude odds ratio of the total group was 1.06 (P = 0.53, 95% CI 0.88-1.28), and the odds ratio adjusted for all pre-defined confounders was 1.00 (P = 0.99, 95% CI 0.81-1.24). The crude and adjusted odds ratios were not showed statistical significance (all P's>0.05).

CONCLUSIONS

By the nested case-control design, this study showed that oral administration of FQ was not associated with the increased risk of development of RRD.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29649310

Citation

Choi, Seung Yong, et al. "Administration of Oral Fluoroquinolone and the Risk of Rhegmatogenous Retinal Detachment: a Nationwide Population-based Study in Korea." PloS One, vol. 13, no. 4, 2018, pp. e0195563.
Choi SY, Lim HA, Yim HW, et al. Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea. PLoS One. 2018;13(4):e0195563.
Choi, S. Y., Lim, H. A., Yim, H. W., & Park, Y. H. (2018). Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea. PloS One, 13(4), e0195563. https://doi.org/10.1371/journal.pone.0195563
Choi SY, et al. Administration of Oral Fluoroquinolone and the Risk of Rhegmatogenous Retinal Detachment: a Nationwide Population-based Study in Korea. PLoS One. 2018;13(4):e0195563. PubMed PMID: 29649310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea. AU - Choi,Seung Yong, AU - Lim,Hyun-A, AU - Yim,Hyeon Woo, AU - Park,Young-Hoon, Y1 - 2018/04/12/ PY - 2018/01/30/received PY - 2018/03/23/accepted PY - 2018/4/13/entrez PY - 2018/4/13/pubmed PY - 2018/7/19/medline SP - e0195563 EP - e0195563 JF - PloS one JO - PLoS One VL - 13 IS - 4 N2 - PURPOSE: To investigate the association between oral fluoroquinolones (FQ) and the risk of rhegmatogenous retinal detachment (RRD) using a nationwide population-based study in Korea, designed to control for time-related bias. METHODS: As a nested case-control study within a cohort, the KNHIS-NSC 2002-2013 (Korean National Health Insurance Service National Sample Cohort) data used for the investigation. The subjects who visited an ophthalmologist were included in a cohort. Subjects with infectious ocular diseases, severe ocular trauma, and congenital diseases were excluded. Within the cohort, subjects who underwent surgery for RRD were defined as cases, and controls were matched by age group, sex, and cohort entry date using an incidence density sampling method. After investigating the exposure to oral FQ, the odds ratio was calculated by the FQ exposure rate of both groups and adjusted by the confounding factors of demography, health service utilization, and comorbidities. RESULTS: A total of 1,151 subjects in the case group and 11,470 subjects in the control group were included. There were intergroup differences in household income, numbers of ophthalmologic visits and drug prescriptions, events of intraocular surgeries, and prevalence of diabetes and degenerative myopia (all P's<0.05). The crude odds ratio of the total group was 1.06 (P = 0.53, 95% CI 0.88-1.28), and the odds ratio adjusted for all pre-defined confounders was 1.00 (P = 0.99, 95% CI 0.81-1.24). The crude and adjusted odds ratios were not showed statistical significance (all P's>0.05). CONCLUSIONS: By the nested case-control design, this study showed that oral administration of FQ was not associated with the increased risk of development of RRD. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29649310/Administration_of_oral_fluoroquinolone_and_the_risk_of_rhegmatogenous_retinal_detachment:_A_nationwide_population_based_study_in_Korea_ L2 - https://dx.plos.org/10.1371/journal.pone.0195563 DB - PRIME DP - Unbound Medicine ER -