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The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
BMC Endocr Disord. 2018 Apr 12; 18(1):21.BE

Abstract

BACKGROUND

To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS.

METHODS

This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Subjects were randomly assigned into two groups to take either synbiotic (n = 30) or placebo (n = 30) for 12 weeks. Endocrine, inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention.

RESULTS

After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (changes from baseline in synbiotic group: + 19.8 ± 47.3 vs. in placebo group: + 0.5 ± 5.4 nmol/L, p = 0.01), plasma nitric oxide (NO) (changes from baseline in synbiotic group: + 5.5 ± 4.8 vs. in placebo group: + 0.3 ± 9.1 μmol/L, p = 0.006), and decreased modified Ferriman Gallwey (mF-G) scores (changes from baseline in synbiotic group: - 1.3 ± 2.5 vs. in placebo group: - 0.1 ± 0.5, p = 0.01) and serum high-sensitivity C-reactive protein (hs-CRP) (changes from baseline in synbiotic group: - 950.0 ± 2246.6 vs. in placebo group: + 335.3 ± 2466.9 ng/mL, p = 0.02). We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress.

CONCLUSIONS

Overall, synbiotic supplementation for 12 weeks in PCOS women had beneficial effects on SHBG, mFG scores, hs-CRP and NO levels, but did not affect other hormonal status and biomarkers of oxidative stress.

TRIAL REGISTRATION

This study was retrospectively registered in the Iranian website (www.irct.ir) for registration of clinical trials (IRCT201509115623N53), on 2015-09-27.

Authors+Show Affiliations

Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.Faculty member of Science department, Science Faculty, Islamic Azad University, Tehran Central Branch, Tehran, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran. asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29649996

Citation

Nasri, Khadijeh, et al. "The Effects of Synbiotic Supplementation On Hormonal Status, Biomarkers of Inflammation and Oxidative Stress in Subjects With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial." BMC Endocrine Disorders, vol. 18, no. 1, 2018, p. 21.
Nasri K, Jamilian M, Rahmani E, et al. The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocr Disord. 2018;18(1):21.
Nasri, K., Jamilian, M., Rahmani, E., Bahmani, F., Tajabadi-Ebrahimi, M., & Asemi, Z. (2018). The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocrine Disorders, 18(1), 21. https://doi.org/10.1186/s12902-018-0248-0
Nasri K, et al. The Effects of Synbiotic Supplementation On Hormonal Status, Biomarkers of Inflammation and Oxidative Stress in Subjects With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial. BMC Endocr Disord. 2018 Apr 12;18(1):21. PubMed PMID: 29649996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. AU - Nasri,Khadijeh, AU - Jamilian,Mehri, AU - Rahmani,Elham, AU - Bahmani,Fereshteh, AU - Tajabadi-Ebrahimi,Maryam, AU - Asemi,Zatollah, Y1 - 2018/04/12/ PY - 2018/01/12/received PY - 2018/04/06/accepted PY - 2018/4/14/entrez PY - 2018/4/14/pubmed PY - 2018/9/20/medline KW - Hormonal status KW - Inflammation KW - Oxidative stress KW - Polycystic ovary syndrome KW - Synbiotic SP - 21 EP - 21 JF - BMC endocrine disorders JO - BMC Endocr Disord VL - 18 IS - 1 N2 - BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Subjects were randomly assigned into two groups to take either synbiotic (n = 30) or placebo (n = 30) for 12 weeks. Endocrine, inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention. RESULTS: After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (changes from baseline in synbiotic group: + 19.8 ± 47.3 vs. in placebo group: + 0.5 ± 5.4 nmol/L, p = 0.01), plasma nitric oxide (NO) (changes from baseline in synbiotic group: + 5.5 ± 4.8 vs. in placebo group: + 0.3 ± 9.1 μmol/L, p = 0.006), and decreased modified Ferriman Gallwey (mF-G) scores (changes from baseline in synbiotic group: - 1.3 ± 2.5 vs. in placebo group: - 0.1 ± 0.5, p = 0.01) and serum high-sensitivity C-reactive protein (hs-CRP) (changes from baseline in synbiotic group: - 950.0 ± 2246.6 vs. in placebo group: + 335.3 ± 2466.9 ng/mL, p = 0.02). We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress. CONCLUSIONS: Overall, synbiotic supplementation for 12 weeks in PCOS women had beneficial effects on SHBG, mFG scores, hs-CRP and NO levels, but did not affect other hormonal status and biomarkers of oxidative stress. TRIAL REGISTRATION: This study was retrospectively registered in the Iranian website (www.irct.ir) for registration of clinical trials (IRCT201509115623N53), on 2015-09-27. SN - 1472-6823 UR - https://www.unboundmedicine.com/medline/citation/29649996/The_effects_of_synbiotic_supplementation_on_hormonal_status_biomarkers_of_inflammation_and_oxidative_stress_in_subjects_with_polycystic_ovary_syndrome:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0248-0 DB - PRIME DP - Unbound Medicine ER -