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Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis.
J Formos Med Assoc. 2018 Aug; 117(8):691-696.JF

Abstract

BACKGROUND/PURPOSE

Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG+RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients.

METHODS

The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG+RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared.

RESULTS

We found that 20.0%, 30.0%, and 26.7% of 30 AG+RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG+RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG+RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant.

CONCLUSION

AG+RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.

Authors+Show Affiliations

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29653880

Citation

Wu, Yu-Hsueh, et al. "Gastric Parietal Cell and Thyroid Autoantibodies in Behcet's Disease Patients With or Without Atrophic Glossitis." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 117, no. 8, 2018, pp. 691-696.
Wu YH, Chang JY, Wang YP, et al. Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. J Formos Med Assoc. 2018;117(8):691-696.
Wu, Y. H., Chang, J. Y., Wang, Y. P., Wu, Y. C., Chen, H. M., & Sun, A. (2018). Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 117(8), 691-696. https://doi.org/10.1016/j.jfma.2018.03.015
Wu YH, et al. Gastric Parietal Cell and Thyroid Autoantibodies in Behcet's Disease Patients With or Without Atrophic Glossitis. J Formos Med Assoc. 2018;117(8):691-696. PubMed PMID: 29653880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. AU - Wu,Yu-Hsueh, AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2018/04/10/ PY - 2018/03/09/received PY - 2018/03/26/revised PY - 2018/03/27/accepted PY - 2018/4/15/pubmed PY - 2018/11/16/medline PY - 2018/4/15/entrez KW - Atrophic glossitis KW - Behcet's disease KW - Gastric parietal cell antibody KW - Recurrent aphthous stomatitis KW - Thyroglobulin antibody KW - Thyroid microsomal antibody SP - 691 EP - 696 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 117 IS - 8 N2 - BACKGROUND/PURPOSE: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG+RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. METHODS: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG+RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. RESULTS: We found that 20.0%, 30.0%, and 26.7% of 30 AG+RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG+RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG+RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. CONCLUSION: AG+RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/29653880/Gastric_parietal_cell_and_thyroid_autoantibodies_in_Behcet's_disease_patients_with_or_without_atrophic_glossitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(18)30161-X DB - PRIME DP - Unbound Medicine ER -