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Dietary Vitamin E Status Dictates Oxidative Stress Outcomes by Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice.
Mol Neurobiol 2018; 55(12):9204-9219MN

Abstract

Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of fish oil supplementation on cognition was dietary VE status associated, fish oil dietary intervention was carried out in transgenic APPswe/PS1dE9 (APP/PS1) mice. Control mice (C57BL/6J mice) were fed a normal control diet. APP/PS1 mice were assigned to a normal control diet group and low VE diet + fish oil supplement, normal VE diet + fish oil supplement, and high VE diet + fish oil supplement groups, respectively. After 7 months of dietary intervention, we found that fish oil supplementation improved behavioral performance, alleviated brain beta-amyloid (Aβ) plaque burden, and attenuated the oxidative stress in APP/PS1 mice by increasing cortical GSH content and total antioxidant capacity, as well as by decreasing MDA level. Fish oil treatment increased cortical n-3 PUFA concentration and decreased n-6/n-3 PUFA ratio in APP/PS1 mice. Fatty acid transporters, Nrf2 and downstream targets involved in cortical and hippocampal antioxidant system were also modulated by fish oil-supplemented diet. Our data demonstrate that fish oil supplementation exerts an enhanced modulatory effect on the antioxidant system and fatty acid concentrations in APP/PS1 mice fed on lowly or averagely concentrated level of VE-containing diet than in mice fed with VE-rich diet. The current data do support previous findings that already dictate the beneficial effect of n-3 PUFAs on cognitive function. Moreover, the cognition promoting effects of n-3 PUFAs may be dietary VE status related.

Authors+Show Affiliations

School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.Department of Orthopaedics and Neurosurgery, Keck Medical Center of USC, University of Southern California, Los Angeles, CA, 90033, USA. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.Center for Disease Control and Prevention, Fengtai District, Beijing, 100071, People's Republic of China.School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China. ylhmedu@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29656360

Citation

Dong, Shengqi, et al. "Dietary Vitamin E Status Dictates Oxidative Stress Outcomes By Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice." Molecular Neurobiology, vol. 55, no. 12, 2018, pp. 9204-9219.
Dong S, Huang X, Zhen J, et al. Dietary Vitamin E Status Dictates Oxidative Stress Outcomes by Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice. Mol Neurobiol. 2018;55(12):9204-9219.
Dong, S., Huang, X., Zhen, J., Van Halm-Lutterodt, N., Wang, J., Zhou, C., & Yuan, L. (2018). Dietary Vitamin E Status Dictates Oxidative Stress Outcomes by Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice. Molecular Neurobiology, 55(12), pp. 9204-9219. doi:10.1007/s12035-018-1060-6.
Dong S, et al. Dietary Vitamin E Status Dictates Oxidative Stress Outcomes By Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice. Mol Neurobiol. 2018;55(12):9204-9219. PubMed PMID: 29656360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Vitamin E Status Dictates Oxidative Stress Outcomes by Modulating Effects of Fish Oil Supplementation in Alzheimer Disease Model APPswe/PS1dE9 Mice. AU - Dong,Shengqi, AU - Huang,Xiaochen, AU - Zhen,Jie, AU - Van Halm-Lutterodt,Nicholas, AU - Wang,JiaJia, AU - Zhou,Cui, AU - Yuan,Linhong, Y1 - 2018/04/14/ PY - 2018/02/23/received PY - 2018/04/03/accepted PY - 2018/4/16/pubmed PY - 2019/1/19/medline PY - 2018/4/16/entrez KW - Cognition KW - Docosahexaenoic acid (DHA) KW - N-3 polyunsaturated fatty acids KW - Vitamin E SP - 9204 EP - 9219 JF - Molecular neurobiology JO - Mol. Neurobiol. VL - 55 IS - 12 N2 - Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of fish oil supplementation on cognition was dietary VE status associated, fish oil dietary intervention was carried out in transgenic APPswe/PS1dE9 (APP/PS1) mice. Control mice (C57BL/6J mice) were fed a normal control diet. APP/PS1 mice were assigned to a normal control diet group and low VE diet + fish oil supplement, normal VE diet + fish oil supplement, and high VE diet + fish oil supplement groups, respectively. After 7 months of dietary intervention, we found that fish oil supplementation improved behavioral performance, alleviated brain beta-amyloid (Aβ) plaque burden, and attenuated the oxidative stress in APP/PS1 mice by increasing cortical GSH content and total antioxidant capacity, as well as by decreasing MDA level. Fish oil treatment increased cortical n-3 PUFA concentration and decreased n-6/n-3 PUFA ratio in APP/PS1 mice. Fatty acid transporters, Nrf2 and downstream targets involved in cortical and hippocampal antioxidant system were also modulated by fish oil-supplemented diet. Our data demonstrate that fish oil supplementation exerts an enhanced modulatory effect on the antioxidant system and fatty acid concentrations in APP/PS1 mice fed on lowly or averagely concentrated level of VE-containing diet than in mice fed with VE-rich diet. The current data do support previous findings that already dictate the beneficial effect of n-3 PUFAs on cognitive function. Moreover, the cognition promoting effects of n-3 PUFAs may be dietary VE status related. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/29656360/Dietary_Vitamin_E_Status_Dictates_Oxidative_Stress_Outcomes_by_Modulating_Effects_of_Fish_Oil_Supplementation_in_Alzheimer_Disease_Model_APPswe/PS1dE9_Mice_ L2 - https://dx.doi.org/10.1007/s12035-018-1060-6 DB - PRIME DP - Unbound Medicine ER -