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Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes.
J Matern Fetal Neonatal Med. 2019 Oct; 32(20):3473-3479.JM

Abstract

Objective:

To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in PPROM and its correlation with latency to delivery.

Methods:

We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls. EA was compared using Mann Whitney and Wilcoxon tests, p value <.05 was considered significant.

Results:

We recruited 20 cases of PPROM and 20 controls. Demographics were similar between groups. Mean GA of PPROM was 29.0 ± 2.2 weeks and median latency was 7.5 (IQR 14.1) weeks. Median EA at admission following PPROM was significantly elevated over controls (0.43 (0.18) versus 0.36 (0.2); p < .02). Overall there was no difference in median EA at admission and in labor (0.43 (0.18) versus 0.33 (0.21); p = .2) following PPROM. However, on comparing cases with latency to delivery ≤7 days (n = 10) versus >7 days (n = 10), there was a significant drop in EA in the latter group (0.44 (0.2) versus 0.34 (0.2); p < .004).

Conclusions:

EA in PPROM represents a promising biomarker in predicting the clinical evolution of preterm birth.

Authors+Show Affiliations

a Department of Obstetric and Gynecology , Sunnybrook Health Sciences Centre, University of Toronto , Toronto , Canada.b Department of Obstetrics and Gynecology , Mount Sinai Hospital, University of Toronto , Toronto , Canada.c Lunenfeld-Tanenbaum Research Institute , Mount Sinai Hospital, University of Toronto , Toronto , Canada.c Lunenfeld-Tanenbaum Research Institute , Mount Sinai Hospital, University of Toronto , Toronto , Canada.b Department of Obstetrics and Gynecology , Mount Sinai Hospital, University of Toronto , Toronto , Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29656690

Citation

Ronzoni, Stefania, et al. "Maternal Blood Endotoxin Activity in Pregnancies Complicated By Preterm Premature Rupture of Membranes." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 32, no. 20, 2019, pp. 3473-3479.
Ronzoni S, D'Souza R, Shynlova O, et al. Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes. J Matern Fetal Neonatal Med. 2019;32(20):3473-3479.
Ronzoni, S., D'Souza, R., Shynlova, O., Lye, S., & Murphy, K. E. (2019). Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 32(20), 3473-3479. https://doi.org/10.1080/14767058.2018.1465560
Ronzoni S, et al. Maternal Blood Endotoxin Activity in Pregnancies Complicated By Preterm Premature Rupture of Membranes. J Matern Fetal Neonatal Med. 2019;32(20):3473-3479. PubMed PMID: 29656690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes. AU - Ronzoni,Stefania, AU - D'Souza,Rohan, AU - Shynlova,Oksana, AU - Lye,Stephen, AU - Murphy,Kellie E, Y1 - 2018/04/26/ PY - 2018/4/17/pubmed PY - 2020/1/22/medline PY - 2018/4/17/entrez KW - Chorioamnionitis KW - endotoxin activity KW - preterm premature rupture of membranes SP - 3473 EP - 3479 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 32 IS - 20 N2 - Objective: To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in PPROM and its correlation with latency to delivery. Methods: We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls. EA was compared using Mann Whitney and Wilcoxon tests, p value <.05 was considered significant. Results: We recruited 20 cases of PPROM and 20 controls. Demographics were similar between groups. Mean GA of PPROM was 29.0 ± 2.2 weeks and median latency was 7.5 (IQR 14.1) weeks. Median EA at admission following PPROM was significantly elevated over controls (0.43 (0.18) versus 0.36 (0.2); p < .02). Overall there was no difference in median EA at admission and in labor (0.43 (0.18) versus 0.33 (0.21); p = .2) following PPROM. However, on comparing cases with latency to delivery ≤7 days (n = 10) versus >7 days (n = 10), there was a significant drop in EA in the latter group (0.44 (0.2) versus 0.34 (0.2); p < .004). Conclusions: EA in PPROM represents a promising biomarker in predicting the clinical evolution of preterm birth. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/29656690/Maternal_blood_endotoxin_activity_in_pregnancies_complicated_by_preterm_premature_rupture_of_membranes_ L2 - http://www.tandfonline.com/doi/full/10.1080/14767058.2018.1465560 DB - PRIME DP - Unbound Medicine ER -