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Computational Approaches to tRNA-Derived Small RNAs.
Noncoding RNA. 2017 Jan 04; 3(1)NR

Abstract

tRNA-derived small RNAs (tDRs) are a group of small, non-coding RNAs derived from transfer RNAs (tRNAs). They can be classified as tRNA halves and tRNA-derived small RNA fragments (tRFs). Accumulating experimental evidence suggests their functional roles in cells and in various biological processes. Advances in next-generation sequencing (NGS) techniques allow a large amount of small RNA deep-sequencing data to be generated. To investigate tDRs from these data, software to identify tDRs and databases to retrieve or manage tDR data have been devised. In this review, we summarized the tools and databases for tDR identification and collection, with the aim of helping researchers choose the best tools for their analysis and inspiring the invention or improvement of tools in the field.

Authors+Show Affiliations

Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. xuwl6@mail2.sysu.edu.cn.Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. yangy238@mail2.sysu.edu.cn.Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. wangyd8@mail2.sysu.edu.cn.Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. lssqlh@mail.sysu.edu.cn.Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. zhengll33@mail.sysu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29657274

Citation

Xu, Wei-Lin, et al. "Computational Approaches to tRNA-Derived Small RNAs." Non-coding RNA, vol. 3, no. 1, 2017.
Xu WL, Yang Y, Wang YD, et al. Computational Approaches to tRNA-Derived Small RNAs. Noncoding RNA. 2017;3(1).
Xu, W. L., Yang, Y., Wang, Y. D., Qu, L. H., & Zheng, L. L. (2017). Computational Approaches to tRNA-Derived Small RNAs. Non-coding RNA, 3(1). https://doi.org/10.3390/ncrna3010002
Xu WL, et al. Computational Approaches to tRNA-Derived Small RNAs. Noncoding RNA. 2017 Jan 4;3(1) PubMed PMID: 29657274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Computational Approaches to tRNA-Derived Small RNAs. AU - Xu,Wei-Lin, AU - Yang,Ye, AU - Wang,Yi-Dan, AU - Qu,Liang-Hu, AU - Zheng,Ling-Ling, Y1 - 2017/01/04/ PY - 2016/11/23/received PY - 2016/12/21/revised PY - 2016/12/26/accepted PY - 2018/4/17/entrez PY - 2017/1/4/pubmed PY - 2017/1/4/medline KW - database KW - identification KW - next-generation sequencing KW - tRNA halves KW - tRNA-derived small RNA KW - tRNA-derived small RNA fragments JF - Non-coding RNA JO - Noncoding RNA VL - 3 IS - 1 N2 - tRNA-derived small RNAs (tDRs) are a group of small, non-coding RNAs derived from transfer RNAs (tRNAs). They can be classified as tRNA halves and tRNA-derived small RNA fragments (tRFs). Accumulating experimental evidence suggests their functional roles in cells and in various biological processes. Advances in next-generation sequencing (NGS) techniques allow a large amount of small RNA deep-sequencing data to be generated. To investigate tDRs from these data, software to identify tDRs and databases to retrieve or manage tDR data have been devised. In this review, we summarized the tools and databases for tDR identification and collection, with the aim of helping researchers choose the best tools for their analysis and inspiring the invention or improvement of tools in the field. SN - 2311-553X UR - https://www.unboundmedicine.com/medline/citation/29657274/Computational_Approaches_to_tRNA_Derived_Small_RNAs_ L2 - https://www.mdpi.com/resolver?pii=ncrna3010002 DB - PRIME DP - Unbound Medicine ER -
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