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Modification of polydopamine-coated Fe3O4 nanoparticles with multi-walled carbon nanotubes for magnetic-μ-dispersive solid-phase extraction of antiepileptic drugs in biological matrices.
Anal Bioanal Chem. 2018 Jun; 410(16):3779-3788.AB

Abstract

In this study, multi-walled carbon nanotubes were coated on the surface of magnetic nanoparticles modified by polydopamine. The synthesized composite was characterized and applied to magnetic-μ-dispersive solid-phase extraction of oxcarbazepine (OXC), phenytoin (PHT), and carbamazepine (CBZ) from human plasma, urine, and cerebrospinal fluid samples prior to analysis by a high-performance liquid chromatography-photodiode array detector. The extraction parameters were investigated and the optimum condition was obtained when the variables were set to the following: sorbent type, Fe3O4@polyDA-MWCNTs (length < 2 μm); sample pH, 6; amount of sorbent, 15 mg; sorption time, 1.5 min at room temperature; type and volume of the eluent, 2.5 mL methanol; and salt content, none added. Under the optimized conditions, the calibration curves are linear in the concentration range 2-2000 ng/mL, the limits of detection are in the range 0.4-3.1 ng/mL, and the relative standard deviations and relative recoveries of plasma (spiked at 200 ng/mL) and CSF (spiked at 50 ng/mL) are in the ranges 1.4-8.2% and 92.8-96.5%, respectively. The applicability of the method was successfully confirmed by extraction and determination of OXC, PHT, and CBZ in biological matrices. Graphical abstract Magnetic multi-walled carbon nanotube core-shell composites were applied as magnetic-μ-dispersive solid-phase extraction adsorbents for determination of antiepileptic drugs in biological matrices.

Authors+Show Affiliations

Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China.The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China.Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China.Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China.Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China.Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China. suping@mail.buct.edu.cn.Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, College of Science, Beijing University of Chemical Technology, No.15, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China. yangyi@mail.buct.edu.cn.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

29658094

Citation

Zhang, Ruiqi, et al. "Modification of Polydopamine-coated Fe3O4 Nanoparticles With Multi-walled Carbon Nanotubes for Magnetic-μ-dispersive Solid-phase Extraction of Antiepileptic Drugs in Biological Matrices." Analytical and Bioanalytical Chemistry, vol. 410, no. 16, 2018, pp. 3779-3788.
Zhang R, Wang S, Yang Y, et al. Modification of polydopamine-coated Fe3O4 nanoparticles with multi-walled carbon nanotubes for magnetic-μ-dispersive solid-phase extraction of antiepileptic drugs in biological matrices. Anal Bioanal Chem. 2018;410(16):3779-3788.
Zhang, R., Wang, S., Yang, Y., Deng, Y., Li, D., Su, P., & Yang, Y. (2018). Modification of polydopamine-coated Fe3O4 nanoparticles with multi-walled carbon nanotubes for magnetic-μ-dispersive solid-phase extraction of antiepileptic drugs in biological matrices. Analytical and Bioanalytical Chemistry, 410(16), 3779-3788. https://doi.org/10.1007/s00216-018-1047-1
Zhang R, et al. Modification of Polydopamine-coated Fe3O4 Nanoparticles With Multi-walled Carbon Nanotubes for Magnetic-μ-dispersive Solid-phase Extraction of Antiepileptic Drugs in Biological Matrices. Anal Bioanal Chem. 2018;410(16):3779-3788. PubMed PMID: 29658094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modification of polydopamine-coated Fe3O4 nanoparticles with multi-walled carbon nanotubes for magnetic-μ-dispersive solid-phase extraction of antiepileptic drugs in biological matrices. AU - Zhang,Ruiqi, AU - Wang,Siming, AU - Yang,Ye, AU - Deng,Yulan, AU - Li,Di, AU - Su,Ping, AU - Yang,Yi, Y1 - 2018/04/16/ PY - 2018/01/01/received PY - 2018/03/26/accepted PY - 2018/03/05/revised PY - 2018/4/17/pubmed PY - 2018/6/30/medline PY - 2018/4/17/entrez KW - Antiepileptic drugs KW - Biological matrices KW - Magnetic multi-walled carbon nanotube KW - Polydopamine SP - 3779 EP - 3788 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 410 IS - 16 N2 - In this study, multi-walled carbon nanotubes were coated on the surface of magnetic nanoparticles modified by polydopamine. The synthesized composite was characterized and applied to magnetic-μ-dispersive solid-phase extraction of oxcarbazepine (OXC), phenytoin (PHT), and carbamazepine (CBZ) from human plasma, urine, and cerebrospinal fluid samples prior to analysis by a high-performance liquid chromatography-photodiode array detector. The extraction parameters were investigated and the optimum condition was obtained when the variables were set to the following: sorbent type, Fe3O4@polyDA-MWCNTs (length < 2 μm); sample pH, 6; amount of sorbent, 15 mg; sorption time, 1.5 min at room temperature; type and volume of the eluent, 2.5 mL methanol; and salt content, none added. Under the optimized conditions, the calibration curves are linear in the concentration range 2-2000 ng/mL, the limits of detection are in the range 0.4-3.1 ng/mL, and the relative standard deviations and relative recoveries of plasma (spiked at 200 ng/mL) and CSF (spiked at 50 ng/mL) are in the ranges 1.4-8.2% and 92.8-96.5%, respectively. The applicability of the method was successfully confirmed by extraction and determination of OXC, PHT, and CBZ in biological matrices. Graphical abstract Magnetic multi-walled carbon nanotube core-shell composites were applied as magnetic-μ-dispersive solid-phase extraction adsorbents for determination of antiepileptic drugs in biological matrices. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/29658094/Modification_of_polydopamine_coated_Fe3O4_nanoparticles_with_multi_walled_carbon_nanotubes_for_magnetic_μ_dispersive_solid_phase_extraction_of_antiepileptic_drugs_in_biological_matrices_ L2 - https://dx.doi.org/10.1007/s00216-018-1047-1 DB - PRIME DP - Unbound Medicine ER -