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Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion.
Gynecol Endocrinol 2018; 34(10):864-867GE

Abstract

BACKGROUND AND AIM

Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. The aim of this study was to evaluate the relationship between serum chemerin and the occurrence of abortion in women with PCOS.

METHODS

We recruited 198 women with PCOS to participate in our study. On the third day of menstrual cycle or a random day in women with amenorrhea, we obtained their venous blood and measured the fasting insulin, fasting plasma glucose, total cholesterol, high density lipoprotein cholesterol, triglyceride, chemerin, and hormones including FSH, E2, P, PRL, LH, and T. Additionally, BMI, HOMA-IR and LH/FSH of each subject were calculated. Finally, 58 of them were included in the study, in which 30 of them had normal pregnancy and the other 28 had an early miscarriage. We compared the biochemical characteristics between the normal pregnancy group and abortion group by independent-samples t test.

RESULTS

In our study, those with a normal pregnancy had a lower level of BMI, FINs, HOMA-IR, and chemerin compared to abortion patients (p < .05). After adjusted for BMI, only chemerin was associated with the occurrence of abortion in PCOS patients (p < .05).

CONCLUSIONS

Serum chemerin level is associated with the occurrence of abortion in patients with PCOS. Thus, serum chemerin may serve as a biomarker to identify pregnant women with PCOS who are at particular risk for later abortion, and who may benefit from prevention strategies.

Authors+Show Affiliations

a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29658354

Citation

Yang, Xuezhou, et al. "Serum Chemerin Level in Women With PCOS and Its Relation With the Risk of Spontaneous Abortion." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 34, no. 10, 2018, pp. 864-867.
Yang X, Quan X, Lan Y, et al. Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion. Gynecol Endocrinol. 2018;34(10):864-867.
Yang, X., Quan, X., Lan, Y., Wei, Q., Ye, J., Yin, X., ... Yang, Y. (2018). Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 34(10), pp. 864-867. doi:10.1080/09513590.2018.1462316.
Yang X, et al. Serum Chemerin Level in Women With PCOS and Its Relation With the Risk of Spontaneous Abortion. Gynecol Endocrinol. 2018;34(10):864-867. PubMed PMID: 29658354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion. AU - Yang,Xuezhou, AU - Quan,Xiaozhen, AU - Lan,Yanli, AU - Wei,Qipeng, AU - Ye,Jinhai, AU - Yin,Xiaofang, AU - Ji,Zhisong, AU - Xing,Hui, AU - Yang,Ying, Y1 - 2018/04/16/ PY - 2018/4/17/pubmed PY - 2018/12/12/medline PY - 2018/4/17/entrez KW - Chemerin KW - insulin resistance KW - miscarriage KW - polycystic ovarian syndrome (PCOS) SP - 864 EP - 867 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 34 IS - 10 N2 - BACKGROUND AND AIM: Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. The aim of this study was to evaluate the relationship between serum chemerin and the occurrence of abortion in women with PCOS. METHODS: We recruited 198 women with PCOS to participate in our study. On the third day of menstrual cycle or a random day in women with amenorrhea, we obtained their venous blood and measured the fasting insulin, fasting plasma glucose, total cholesterol, high density lipoprotein cholesterol, triglyceride, chemerin, and hormones including FSH, E2, P, PRL, LH, and T. Additionally, BMI, HOMA-IR and LH/FSH of each subject were calculated. Finally, 58 of them were included in the study, in which 30 of them had normal pregnancy and the other 28 had an early miscarriage. We compared the biochemical characteristics between the normal pregnancy group and abortion group by independent-samples t test. RESULTS: In our study, those with a normal pregnancy had a lower level of BMI, FINs, HOMA-IR, and chemerin compared to abortion patients (p < .05). After adjusted for BMI, only chemerin was associated with the occurrence of abortion in PCOS patients (p < .05). CONCLUSIONS: Serum chemerin level is associated with the occurrence of abortion in patients with PCOS. Thus, serum chemerin may serve as a biomarker to identify pregnant women with PCOS who are at particular risk for later abortion, and who may benefit from prevention strategies. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/29658354/Serum_chemerin_level_in_women_with_PCOS_and_its_relation_with_the_risk_of_spontaneous_abortion_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2018.1462316 DB - PRIME DP - Unbound Medicine ER -