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Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women.
Cancer Sci 2018; 109(6):2003-2012CS

Abstract

Although cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3-year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and HPV testing were carried out. Women with abnormal cytology or HPV16/18 positivity underwent colposcopy. Those with 12 other high-risk (hr) HPV types underwent repeat cytology after 6 months. Primary study endpoints were detection of high-grade cervical disease defined as CIN2/CIN3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hrHPV, HPV 16, and HPV 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. HPV16/18 were detected in all (8/8) invasive cervical cancers and in all (2/2) adenocarcinomas in situ. Both cytological abnormalities and hrHPV positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an HPV-based screening program. Results should help policy-makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on HPV genotype.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Women's Healthcare Center, Otaru General Hospital, Otaru, Japan.Hokkaido Cancer Society, Sapporo, Japan.Department of Women's Health Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.Hokkaido Cancer Society, Asahikawa, Japan.Hokkaido Cancer Society, Sapporo, Japan.Department of Pathology, Sapporo Medical University, Sapporo, Japan.Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.Department of Public Health, Faculty of Medicine, Hokkaido University, Sapporo, Japan.Hokkaido Cancer Society, Sapporo, Japan.Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan.Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.Department of Women's Health Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.Department of Obstetrics and Gynecology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan.Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.Women's Healthcare Center, Otaru General Hospital, Otaru, Japan. Department of Women's Health Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan. Department of Obstetrics and Gynecology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

29660849

Citation

Aoyama-Kikawa, Satomi, et al. "Comparison of Human Papillomavirus Genotyping and Cytology Triage, COMPACT Study: Design, Methods and Baseline Results in 14 642 Women." Cancer Science, vol. 109, no. 6, 2018, pp. 2003-2012.
Aoyama-Kikawa S, Fujita H, Hanley SJB, et al. Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women. Cancer Sci. 2018;109(6):2003-2012.
Aoyama-Kikawa, S., Fujita, H., Hanley, S. J. B., Kasamo, M., Kikuchi, K., Torigoe, T., ... Sakuragi, N. (2018). Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women. Cancer Science, 109(6), pp. 2003-2012. doi:10.1111/cas.13608.
Aoyama-Kikawa S, et al. Comparison of Human Papillomavirus Genotyping and Cytology Triage, COMPACT Study: Design, Methods and Baseline Results in 14 642 Women. Cancer Sci. 2018;109(6):2003-2012. PubMed PMID: 29660849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women. AU - Aoyama-Kikawa,Satomi, AU - Fujita,Hiromasa, AU - Hanley,Sharon J B, AU - Kasamo,Mitsunori, AU - Kikuchi,Kokichi, AU - Torigoe,Toshihiko, AU - Matsuno,Yoshihiro, AU - Tamakoshi,Akiko, AU - Sasaki,Takayuki, AU - Matsuura,Motoki, AU - Kato,Yasuhito, AU - Dong,Peixin, AU - Watari,Hidemichi, AU - Saito,Tsuyoshi, AU - Sengoku,Kazuo, AU - Sakuragi,Noriaki, Y1 - 2018/05/31/ PY - 2018/04/04/received PY - 2018/04/06/accepted PY - 2018/4/17/pubmed PY - 2018/6/21/medline PY - 2018/4/17/entrez KW - COMPACT Study KW - cervical cancer screening KW - human papillomavirus deoxyribonucleic acid testing KW - partial genotyping KW - triage SP - 2003 EP - 2012 JF - Cancer science JO - Cancer Sci. VL - 109 IS - 6 N2 - Although cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3-year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and HPV testing were carried out. Women with abnormal cytology or HPV16/18 positivity underwent colposcopy. Those with 12 other high-risk (hr) HPV types underwent repeat cytology after 6 months. Primary study endpoints were detection of high-grade cervical disease defined as CIN2/CIN3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hrHPV, HPV 16, and HPV 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. HPV16/18 were detected in all (8/8) invasive cervical cancers and in all (2/2) adenocarcinomas in situ. Both cytological abnormalities and hrHPV positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an HPV-based screening program. Results should help policy-makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on HPV genotype. SN - 1349-7006 UR - https://www.unboundmedicine.com/medline/citation/29660849/Comparison_of_human_papillomavirus_genotyping_and_cytology_triage_COMPACT_Study:_Design_methods_and_baseline_results_in_14_642_women_ L2 - https://doi.org/10.1111/cas.13608 DB - PRIME DP - Unbound Medicine ER -