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Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer.
Eur Spine J. 2018 07; 27(Suppl 3):526-532.ES

Abstract

PURPOSE

Tenosynovial giant cell tumor of the diffuse type (TGCT-D) involving the spine is rare. Its differential diagnosis includes metastatic disease; however, there have been few reports of spinal TGCT-D mimicking spinal metastasis in patients with a history of malignancy.

METHODS

We report on a 35-year-old woman with a history of papillary thyroid cancer who was diagnosed with TGCT-D of the thoracic spine mimicking spinal metastasis. Preoperative computed tomography (CT) revealed a 1.0 × 1.0-cm lytic bone lesion involving the left T7 vertebral lamina, pedicle, and the T6-7 facet joint; the thoracic spine lesion was markedly fluorodeoxyglucose-avid on positron-emission tomography/computed tomography (PET/CT).

RESULTS

Spinal metastasis was initially suspected given the patient's history of papillary thyroid cancer. Total excision was performed with recapping laminoplasty. The resected lamina was frozen in liquid nitrogen and used as a frozen autograft (frozen recapping laminoplasty) for spinal reconstruction with posterior instrumentation. Histological findings supported a diagnosis of TGCT-D. The patient had no evidence of local recurrence 2 years post-surgery. Bone union was achieved 3 years post-surgery.

CONCLUSIONS

TGCT-D can mimic metastasis in PET/CT and should be included in the differential diagnosis if a lytic lesion affecting the posterior elements of the vertebrae involves the facet joints. CT-guided biopsy is recommended for accurate diagnosis when an occult tumor, such as TGCT, is incidentally detected on PET-CT, even in patients with a history of malignant neoplasm. Frozen recapping laminoplasty is useful for complete resection of a spinal tumor, preventing local recurrence, and preservation of the posterior spinal elements.

Authors+Show Affiliations

Department of Orthopedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.Department of Orthopedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. hmuraka@med.kanazawa-u.ac.jp.Department of Orthopedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.Department of Orthopedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.Department of Orthopedic Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29663145

Citation

Yonezawa, Noritaka, et al. "Successful Treatment of a Diffuse Type Tenosynovial Giant Cell Tumor in the Thoracic Spine Mimicking Spinal Metastasis By Frozen Recapping Laminoplasty in a Patient With Thyroid Cancer." European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, vol. 27, no. Suppl 3, 2018, pp. 526-532.
Yonezawa N, Murakami H, Kato S, et al. Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. Eur Spine J. 2018;27(Suppl 3):526-532.
Yonezawa, N., Murakami, H., Kato, S., Hayashi, H., & Tsuchiya, H. (2018). Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 27(Suppl 3), 526-532. https://doi.org/10.1007/s00586-018-5603-3
Yonezawa N, et al. Successful Treatment of a Diffuse Type Tenosynovial Giant Cell Tumor in the Thoracic Spine Mimicking Spinal Metastasis By Frozen Recapping Laminoplasty in a Patient With Thyroid Cancer. Eur Spine J. 2018;27(Suppl 3):526-532. PubMed PMID: 29663145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. AU - Yonezawa,Noritaka, AU - Murakami,Hideki, AU - Kato,Satoshi, AU - Hayashi,Hiroyuki, AU - Tsuchiya,Hiroyuki, Y1 - 2018/04/16/ PY - 2017/06/18/received PY - 2018/04/12/accepted PY - 2018/4/18/pubmed PY - 2019/2/28/medline PY - 2018/4/18/entrez KW - Frozen autograft KW - Recapping laminoplasty KW - Tenosynovial giant cell tumor KW - Thoracic spine KW - Thyroid cancer SP - 526 EP - 532 JF - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JO - Eur Spine J VL - 27 IS - Suppl 3 N2 - PURPOSE: Tenosynovial giant cell tumor of the diffuse type (TGCT-D) involving the spine is rare. Its differential diagnosis includes metastatic disease; however, there have been few reports of spinal TGCT-D mimicking spinal metastasis in patients with a history of malignancy. METHODS: We report on a 35-year-old woman with a history of papillary thyroid cancer who was diagnosed with TGCT-D of the thoracic spine mimicking spinal metastasis. Preoperative computed tomography (CT) revealed a 1.0 × 1.0-cm lytic bone lesion involving the left T7 vertebral lamina, pedicle, and the T6-7 facet joint; the thoracic spine lesion was markedly fluorodeoxyglucose-avid on positron-emission tomography/computed tomography (PET/CT). RESULTS: Spinal metastasis was initially suspected given the patient's history of papillary thyroid cancer. Total excision was performed with recapping laminoplasty. The resected lamina was frozen in liquid nitrogen and used as a frozen autograft (frozen recapping laminoplasty) for spinal reconstruction with posterior instrumentation. Histological findings supported a diagnosis of TGCT-D. The patient had no evidence of local recurrence 2 years post-surgery. Bone union was achieved 3 years post-surgery. CONCLUSIONS: TGCT-D can mimic metastasis in PET/CT and should be included in the differential diagnosis if a lytic lesion affecting the posterior elements of the vertebrae involves the facet joints. CT-guided biopsy is recommended for accurate diagnosis when an occult tumor, such as TGCT, is incidentally detected on PET-CT, even in patients with a history of malignant neoplasm. Frozen recapping laminoplasty is useful for complete resection of a spinal tumor, preventing local recurrence, and preservation of the posterior spinal elements. SN - 1432-0932 UR - https://www.unboundmedicine.com/medline/citation/29663145/Successful_treatment_of_a_diffuse_type_tenosynovial_giant_cell_tumor_in_the_thoracic_spine_mimicking_spinal_metastasis_by_frozen_recapping_laminoplasty_in_a_patient_with_thyroid_cancer_ DB - PRIME DP - Unbound Medicine ER -