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Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk.
Int J Cancer 2018; 143(6):1356-1366IJ

Abstract

Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend = 0.037) and 0.54 (95% CI: 0.32-0.92; p-trend = 0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk.

Authors+Show Affiliations

Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Preventive Medicine and Public Health, University of Navarra-Navarra Institute for Health Research, Pamplona, Spain.Department of Preventive Medicine, University of Valencia, Valencia, Spain. Servicio de Oncología, Hospital de Sagunto, Valencia, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Internal Medicine, Hospital Clínic. University of Barcelona, Barcelona, Spain. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. Department of Lipids, Hospital Clínic, University of Barcelona, Barcelona, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Cardiovascular Risk and Nutrition Research (REGICOR Group), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Cardiology, University Hospital Araba, Vitoria, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Balearic Islands Health Research Institute (IdISBa) and Son Espases Hospital, Palma, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Centro de Salud Universitario San Pablo, Sevilla, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Preventive Medicine and Public Health, University of Navarra-Navarra Institute for Health Research, Pamplona, Spain.CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Preventive Medicine, University of Valencia, Valencia, Spain.Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

29663376

Citation

Barrubés, Laura, et al. "Dairy Product Consumption and Risk of Colorectal Cancer in an Older Mediterranean Population at High Cardiovascular Risk." International Journal of Cancer, vol. 143, no. 6, 2018, pp. 1356-1366.
Barrubés L, Babio N, Mena-Sánchez G, et al. Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk. Int J Cancer. 2018;143(6):1356-1366.
Barrubés, L., Babio, N., Mena-Sánchez, G., Toledo, E., Ramírez-Sabio, J. B., Estruch, R., ... Salas-Salvadó, J. (2018). Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk. International Journal of Cancer, 143(6), pp. 1356-1366. doi:10.1002/ijc.31540.
Barrubés L, et al. Dairy Product Consumption and Risk of Colorectal Cancer in an Older Mediterranean Population at High Cardiovascular Risk. Int J Cancer. 2018 09 15;143(6):1356-1366. PubMed PMID: 29663376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk. AU - Barrubés,Laura, AU - Babio,Nancy, AU - Mena-Sánchez,Guillermo, AU - Toledo,Estefania, AU - Ramírez-Sabio,Judith B, AU - Estruch,Ramón, AU - Ros,Emilio, AU - Fitó,Montserrat, AU - Arós,Fernando, AU - Fiol,Miquel, AU - Santos-Lozano,José Manuel, AU - Serra-Majem,Lluís, AU - Pintó,Xavier, AU - Martínez-González,Miguel Ángel, AU - Sorlí,José Vicente, AU - Basora,Josep, AU - Salas-Salvadó,Jordi, AU - ,, Y1 - 2018/05/04/ PY - 2017/12/28/received PY - 2018/03/13/revised PY - 2018/04/10/accepted PY - 2018/4/18/pubmed PY - 2019/2/5/medline PY - 2018/4/18/entrez KW - PREDIMED study KW - colorectal cancer KW - dairy products KW - mediterranean diet KW - milk SP - 1356 EP - 1366 JF - International journal of cancer JO - Int. J. Cancer VL - 143 IS - 6 N2 - Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend = 0.037) and 0.54 (95% CI: 0.32-0.92; p-trend = 0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/29663376/Dairy_product_consumption_and_risk_of_colorectal_cancer_in_an_older_mediterranean_population_at_high_cardiovascular_risk_ L2 - https://doi.org/10.1002/ijc.31540 DB - PRIME DP - Unbound Medicine ER -