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Comparison of outcomes after HLA-matched unrelated and αβ T-cell-depleted haploidentical hematopoietic stem cell transplantation for children with high-risk acute leukemia.
Pediatr Transplant. 2018 06; 22(4):e13192.PT

Abstract

T-cell-depleted HAPLO HSCT is an option to treat children with high-risk acute leukemia lacking an HLA-identical donor. We reviewed the outcome of children with acute leukemia after HAPLO (n = 21) and HLA-MUD (n = 32) transplantation. The proportion of patients with ≥CR2 was significantly higher in HAPLO transplantation than MUD transplantation. Patients with MUD transplantation were significantly higher ABO incompatible than patients with HAPLO transplantation. There was no difference between the 2 groups in terms of engraftment, aGvHD and cGvHD, VOD, hemorrhagic cystitis, infections, and relapse. The 5-year OS of MUD transplantation and HAPLO transplantation groups was found 65.8% and 71.1%, respectively (log-rank 0.51). The 5-year RFS was 80.7% for MUD transplantation group and 86.9% for HAPLO transplantation group (log-rank 0.48). There was no statistically significant difference between 2 groups according to TRM (25% MUD transplantation vs 16.3% HAPLO transplantation, log-rank 0.48). These data suggest that survival for patients with high-risk acute leukemia after HAPLO transplantation with ex vivo ɑβ+ T-cell depletion is comparable with MUD transplantation.

Authors+Show Affiliations

Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, Acıbadem University School of Medicine, Atakent Hospital, İstanbul, Turkey.Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, Acıbadem University School of Medicine, Atakent Hospital, İstanbul, Turkey.Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, Acıbadem University School of Medicine, Atakent Hospital, İstanbul, Turkey.Department of Hematology, Acıbadem University School of Medicine, Altunizade Hospital, İstanbul, Turkey.Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, Acıbadem University School of Medicine, Atakent Hospital, İstanbul, Turkey.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29663666

Citation

Erbey, Fatih, et al. "Comparison of Outcomes After HLA-matched Unrelated and Αβ T-cell-depleted Haploidentical Hematopoietic Stem Cell Transplantation for Children With High-risk Acute Leukemia." Pediatric Transplantation, vol. 22, no. 4, 2018, pp. e13192.
Erbey F, Akçay A, Atay D, et al. Comparison of outcomes after HLA-matched unrelated and αβ T-cell-depleted haploidentical hematopoietic stem cell transplantation for children with high-risk acute leukemia. Pediatr Transplant. 2018;22(4):e13192.
Erbey, F., Akçay, A., Atay, D., Ovalı, E., & Öztürk, G. (2018). Comparison of outcomes after HLA-matched unrelated and αβ T-cell-depleted haploidentical hematopoietic stem cell transplantation for children with high-risk acute leukemia. Pediatric Transplantation, 22(4), e13192. https://doi.org/10.1111/petr.13192
Erbey F, et al. Comparison of Outcomes After HLA-matched Unrelated and Αβ T-cell-depleted Haploidentical Hematopoietic Stem Cell Transplantation for Children With High-risk Acute Leukemia. Pediatr Transplant. 2018;22(4):e13192. PubMed PMID: 29663666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of outcomes after HLA-matched unrelated and αβ T-cell-depleted haploidentical hematopoietic stem cell transplantation for children with high-risk acute leukemia. AU - Erbey,Fatih, AU - Akçay,Arzu, AU - Atay,Didem, AU - Ovalı,Ercüment, AU - Öztürk,Gülyüz, Y1 - 2018/04/16/ PY - 2018/03/07/accepted PY - 2018/4/18/pubmed PY - 2018/10/4/medline PY - 2018/4/18/entrez KW - acute leukemia KW - allogeneic stem cell transplantation KW - children KW - haploidentical SP - e13192 EP - e13192 JF - Pediatric transplantation JO - Pediatr Transplant VL - 22 IS - 4 N2 - T-cell-depleted HAPLO HSCT is an option to treat children with high-risk acute leukemia lacking an HLA-identical donor. We reviewed the outcome of children with acute leukemia after HAPLO (n = 21) and HLA-MUD (n = 32) transplantation. The proportion of patients with ≥CR2 was significantly higher in HAPLO transplantation than MUD transplantation. Patients with MUD transplantation were significantly higher ABO incompatible than patients with HAPLO transplantation. There was no difference between the 2 groups in terms of engraftment, aGvHD and cGvHD, VOD, hemorrhagic cystitis, infections, and relapse. The 5-year OS of MUD transplantation and HAPLO transplantation groups was found 65.8% and 71.1%, respectively (log-rank 0.51). The 5-year RFS was 80.7% for MUD transplantation group and 86.9% for HAPLO transplantation group (log-rank 0.48). There was no statistically significant difference between 2 groups according to TRM (25% MUD transplantation vs 16.3% HAPLO transplantation, log-rank 0.48). These data suggest that survival for patients with high-risk acute leukemia after HAPLO transplantation with ex vivo ɑβ+ T-cell depletion is comparable with MUD transplantation. SN - 1399-3046 UR - https://www.unboundmedicine.com/medline/citation/29663666/Comparison_of_outcomes_after_HLA_matched_unrelated_and_αβ_T_cell_depleted_haploidentical_hematopoietic_stem_cell_transplantation_for_children_with_high_risk_acute_leukemia_ L2 - https://doi.org/10.1111/petr.13192 DB - PRIME DP - Unbound Medicine ER -