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The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis.
Thromb Haemost. 1988 Feb 25; 59(1):18-22.TH

Abstract

The frequency of heterozygous protein C and protein S deficiency, detected by measuring total plasma antigen, in a group (n = 141) of young unrelated patients (less than 45 years old) with venous thrombotic disease was studied and compared to that of antithrombin III, fibrinogen, and plasminogen deficiencies. Among 91 patients not receiving oral anticoagulants, six had low protein S antigen levels and one had a low protein C antigen level. Among 50 patients receiving oral anticoagulant therapy, abnormally low ratios of protein S or C to other vitamin K-dependent factors were presented by one patient for protein S and five for protein C. Thus, heterozygous Type I protein S deficiency appeared in seven of 141 patients (5%) and heterozygous Type I protein C deficiency in six of 141 patients (4%). Eleven of thirteen deficient patients had recurrent venous thrombosis. In this group of 141 patients, 1% had an identifiable fibrinogen abnormality, 2% a plasminogen abnormality, and 3% an antithrombin III deficiency. Thus, among the known plasma protein deficiencies associated with venous thrombosis, protein S and protein C deficiencies (9%) emerge as the leading identifiable associated abnormalities.

Authors+Show Affiliations

Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2966450

Citation

Gladson, C L., et al. "The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients With Venous Thrombosis." Thrombosis and Haemostasis, vol. 59, no. 1, 1988, pp. 18-22.
Gladson CL, Scharrer I, Hach V, et al. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost. 1988;59(1):18-22.
Gladson, C. L., Scharrer, I., Hach, V., Beck, K. H., & Griffin, J. H. (1988). The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thrombosis and Haemostasis, 59(1), 18-22.
Gladson CL, et al. The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients With Venous Thrombosis. Thromb Haemost. 1988 Feb 25;59(1):18-22. PubMed PMID: 2966450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. AU - Gladson,C L, AU - Scharrer,I, AU - Hach,V, AU - Beck,K H, AU - Griffin,J H, PY - 1988/2/25/pubmed PY - 1988/2/25/medline PY - 1988/2/25/entrez SP - 18 EP - 22 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 59 IS - 1 N2 - The frequency of heterozygous protein C and protein S deficiency, detected by measuring total plasma antigen, in a group (n = 141) of young unrelated patients (less than 45 years old) with venous thrombotic disease was studied and compared to that of antithrombin III, fibrinogen, and plasminogen deficiencies. Among 91 patients not receiving oral anticoagulants, six had low protein S antigen levels and one had a low protein C antigen level. Among 50 patients receiving oral anticoagulant therapy, abnormally low ratios of protein S or C to other vitamin K-dependent factors were presented by one patient for protein S and five for protein C. Thus, heterozygous Type I protein S deficiency appeared in seven of 141 patients (5%) and heterozygous Type I protein C deficiency in six of 141 patients (4%). Eleven of thirteen deficient patients had recurrent venous thrombosis. In this group of 141 patients, 1% had an identifiable fibrinogen abnormality, 2% a plasminogen abnormality, and 3% an antithrombin III deficiency. Thus, among the known plasma protein deficiencies associated with venous thrombosis, protein S and protein C deficiencies (9%) emerge as the leading identifiable associated abnormalities. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/2966450/The_frequency_of_type_I_heterozygous_protein_S_and_protein_C_deficiency_in_141_unrelated_young_patients_with_venous_thrombosis_ L2 - http://www.diseaseinfosearch.org/result/6003 DB - PRIME DP - Unbound Medicine ER -