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Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Arch Iran Med. 2018 01 01; 21(1):1-7.AI

Abstract

BACKGROUND

To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS.

METHODS

This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old. Subjects were randomly assigned into 2 groups to receive either probiotics or placebo (n = 30 each group) for 12 weeks. Metabolic profiles were quantified at baseline and after a 12-week intervention.

RESULTS

After the 12-week intervention, compared with placebo, probiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (+25.9 ± 32.5 vs. +0.5 ± 15.6 nmol/L, P < 0.001) and plasma total antioxidant capacity (TAC) (+8.8 ± 120.5 vs. -98.3 ± 246.4 mmol/L, P = 0.04), and significantly decreased serum total testosterone (-0.2 ± 0.7 vs. +0.2 ± 0.6 ng/mL, P = 0.03), modified Ferriman-Gallwey (mF-G) scores (-1.7 ± 1.5 vs. -0.2 ± 1.0, P < 0.001), serum high-sensitivity C-reactive protein (hs-CRP) (-1150.0 ± 1295.2 vs. +202.5 ± 1426.3 ng/mL, P < 0.001) and plasma malondialdehyde (MDA) concentrations (-0.2 ± 0.6 vs. +0.9 ± 1.3 µmol/L, P < 0.001). We did not observe any detrimental effect of probiotic supplementation on other metabolic profiles.

CONCLUSION

Overall, probiotic supplementation of PCOS women for 12 weeks had beneficial effects on total testosterone, SHBG, mFG scores, hs-CRP, TAC and MDA levels but did not affect other metabolic profiles.

Authors+Show Affiliations

Karamali M
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Eghbalpour S
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Rajabi S
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Jamilian M
Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Bahmani F
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Tajabadi-Ebrahimi M
Faculty member of Science Department, Science Faculty, Islamic Azad University, Tehran Central branch, Tehran, Iran.
Keneshlou F
Department of Urology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mirhashemi SM
Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Chamani M
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Hashem Gelougerdi S
Department of Gynecology and Obstetrics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asemi Z
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

MeSH

AdolescentAdultAntioxidantsBiomarkersC-Reactive ProteinDouble-Blind MethodFemaleHumansInflammationIranMalondialdehydeOxidative StressPolycystic Ovary SyndromeProbioticsTestosteroneYoung Adult

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29664663

Clinical Trial Links

Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS

Citation

Karamali, Maryam, et al. "Effects of Probiotic Supplementation On Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial." Archives of Iranian Medicine, vol. 21, no. 1, 2018, pp. 1-7.
Karamali M, Eghbalpour S, Rajabi S, et al. Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Arch Iran Med. 2018;21(1):1-7.
Karamali, M., Eghbalpour, S., Rajabi, S., Jamilian, M., Bahmani, F., Tajabadi-Ebrahimi, M., Keneshlou, F., Mirhashemi, S. M., Chamani, M., Hashem Gelougerdi, S., & Asemi, Z. (2018). Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Archives of Iranian Medicine, 21(1), 1-7.
Karamali M, et al. Effects of Probiotic Supplementation On Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Arch Iran Med. 2018 01 1;21(1):1-7. PubMed PMID: 29664663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. AU - Karamali,Maryam, AU - Eghbalpour,Sara, AU - Rajabi,Sajad, AU - Jamilian,Mehri, AU - Bahmani,Fereshteh, AU - Tajabadi-Ebrahimi,Maryam, AU - Keneshlou,Fariba, AU - Mirhashemi,Seyyed Mehdi, AU - Chamani,Maryam, AU - Hashem Gelougerdi,Sara, AU - Asemi,Zatollah, Y1 - 2018/01/01/ PY - 2017/11/07/received PY - 2017/12/17/accepted PY - 2018/4/18/entrez PY - 2018/4/18/pubmed PY - 2019/7/16/medline KW - Hormonal profiles KW - Inflammation KW - Oxidative stress KW - Polycystic ovary syndrome KW - Probiotic SP - 1 EP - 7 JF - Archives of Iranian medicine JO - Arch Iran Med VL - 21 IS - 1 N2 - BACKGROUND: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS. METHODS: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old. Subjects were randomly assigned into 2 groups to receive either probiotics or placebo (n = 30 each group) for 12 weeks. Metabolic profiles were quantified at baseline and after a 12-week intervention. RESULTS: After the 12-week intervention, compared with placebo, probiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (+25.9 ± 32.5 vs. +0.5 ± 15.6 nmol/L, P < 0.001) and plasma total antioxidant capacity (TAC) (+8.8 ± 120.5 vs. -98.3 ± 246.4 mmol/L, P = 0.04), and significantly decreased serum total testosterone (-0.2 ± 0.7 vs. +0.2 ± 0.6 ng/mL, P = 0.03), modified Ferriman-Gallwey (mF-G) scores (-1.7 ± 1.5 vs. -0.2 ± 1.0, P < 0.001), serum high-sensitivity C-reactive protein (hs-CRP) (-1150.0 ± 1295.2 vs. +202.5 ± 1426.3 ng/mL, P < 0.001) and plasma malondialdehyde (MDA) concentrations (-0.2 ± 0.6 vs. +0.9 ± 1.3 µmol/L, P < 0.001). We did not observe any detrimental effect of probiotic supplementation on other metabolic profiles. CONCLUSION: Overall, probiotic supplementation of PCOS women for 12 weeks had beneficial effects on total testosterone, SHBG, mFG scores, hs-CRP, TAC and MDA levels but did not affect other metabolic profiles. SN - 1735-3947 UR - https://www.unboundmedicine.com/medline/citation/29664663/Effects_of_Probiotic_Supplementation_on_Hormonal_Profiles_Biomarkers_of_Inflammation_and_Oxidative_Stress_in_Women_With_Polycystic_Ovary_Syndrome:_A_Randomized_Double_Blind_Placebo_Controlled_Trial_ DB - PRIME DP - Unbound Medicine ER -
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