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All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision.
Breast. 2018 Aug; 40:4-9.B

Abstract

BACKGROUND

The purposes of this study were to evaluate the outcome of women with pure flat atypical atypia (FEA) diagnosed at vacuum-assisted breast biopsy (VABB) targeting microcalcifications and to determine whether clinical, radiological and pathologic parameters are able to predict which lesions will be upgraded to malignancy.

MATERIALS

2414 cases of consecutive VABB for microcalcifications using VA 8-, 10- or 11-Gauge stereotactically guided core biopsy performed between January 2005 and December 2011 from two french breast cancer centers were evaluated. Data of women with VABB-diagnosed pure FEA who underwent either excisional surgery or mammographic follow-up were analyzed. Cases with mass lesions or ipsilateral cancers were excluded. Two pathologists (FA,PM) reviewed the results of procedures performed. Clinical, radiological, as well as histological criteria have been studied in order to determine the correlation between these factors and carcinoma underestimation.

RESULTS AND CONCLUSION

This study included 70 cases of pure FEA. Twenty women underwent surgical excision and 50 had clinical and mammographic surveillance only. In three women FEA was upgraded to breast cancer on excision. Clinical and mammographic follow-up for a mean of 56 months ± 27 in the group without excision showed two cancers in the same breast (Intermediate grade DCIS, and invasive ductal carcinoma 84 and 48 months respectively after VABB). Three factors were significantly predictive of underestimation or occurence of cancer for pure FEA when the radiologic lesions are calcifications: age≥ 57 years, radiologic size >10 mm and number of FEA foci ≥4.

Authors+Show Affiliations

Department of Gynecology, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France; INSERM Unit 1069, Tours, France; François Rabelais University, Tours, France. Electronic address: l.ouldamer@chu-tours.fr.Department of Gynecology, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France; François Rabelais University, Tours, France.Department of Pathology, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France.Department of Pathology, CHR D'Orléans, Hôpital La Source, Orléans, France.Department of Radiology, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France.Department of Gynecology, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France; François Rabelais University, Tours, France.Department of Pathology, CHR D'Orléans, Hôpital La Source, Orléans, France.

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

29665448

Citation

Ouldamer, Lobna, et al. "All Pure Flat Atypical Atypia Lesions of the Breast Diagnosed Using Percutaneous Vacuum-assisted Breast Biopsy Do Not Need Surgical Excision." Breast (Edinburgh, Scotland), vol. 40, 2018, pp. 4-9.
Ouldamer L, Poisson E, Arbion F, et al. All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast. 2018;40:4-9.
Ouldamer, L., Poisson, E., Arbion, F., Bonneau, C., Vildé, A., Body, G., & Michenet, P. (2018). All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast (Edinburgh, Scotland), 40, 4-9. https://doi.org/10.1016/j.breast.2018.03.012
Ouldamer L, et al. All Pure Flat Atypical Atypia Lesions of the Breast Diagnosed Using Percutaneous Vacuum-assisted Breast Biopsy Do Not Need Surgical Excision. Breast. 2018;40:4-9. PubMed PMID: 29665448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. AU - Ouldamer,Lobna, AU - Poisson,Elodie, AU - Arbion,Flavie, AU - Bonneau,Carole, AU - Vildé,Anne, AU - Body,Gilles, AU - Michenet,Patrick, Y1 - 2018/04/14/ PY - 2017/11/18/received PY - 2018/03/18/revised PY - 2018/03/26/accepted PY - 2018/4/18/pubmed PY - 2018/11/9/medline PY - 2018/4/18/entrez KW - Breast cancer KW - Flat epithelial atypia KW - Stereotactic vacuum-assisted breast biopsy KW - Underestimation SP - 4 EP - 9 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 40 N2 - BACKGROUND: The purposes of this study were to evaluate the outcome of women with pure flat atypical atypia (FEA) diagnosed at vacuum-assisted breast biopsy (VABB) targeting microcalcifications and to determine whether clinical, radiological and pathologic parameters are able to predict which lesions will be upgraded to malignancy. MATERIALS: 2414 cases of consecutive VABB for microcalcifications using VA 8-, 10- or 11-Gauge stereotactically guided core biopsy performed between January 2005 and December 2011 from two french breast cancer centers were evaluated. Data of women with VABB-diagnosed pure FEA who underwent either excisional surgery or mammographic follow-up were analyzed. Cases with mass lesions or ipsilateral cancers were excluded. Two pathologists (FA,PM) reviewed the results of procedures performed. Clinical, radiological, as well as histological criteria have been studied in order to determine the correlation between these factors and carcinoma underestimation. RESULTS AND CONCLUSION: This study included 70 cases of pure FEA. Twenty women underwent surgical excision and 50 had clinical and mammographic surveillance only. In three women FEA was upgraded to breast cancer on excision. Clinical and mammographic follow-up for a mean of 56 months ± 27 in the group without excision showed two cancers in the same breast (Intermediate grade DCIS, and invasive ductal carcinoma 84 and 48 months respectively after VABB). Three factors were significantly predictive of underestimation or occurence of cancer for pure FEA when the radiologic lesions are calcifications: age≥ 57 years, radiologic size >10 mm and number of FEA foci ≥4. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/29665448/All_pure_flat_atypical_atypia_lesions_of_the_breast_diagnosed_using_percutaneous_vacuum_assisted_breast_biopsy_do_not_need_surgical_excision_ DB - PRIME DP - Unbound Medicine ER -