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Effects of statin therapy on chronic kidney disease patients with coronary artery disease.
Lipids Health Dis. 2018 Apr 17; 17(1):84.LH

Abstract

BACKGROUND

Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in CKD + CAD patients.

METHODS

We compared the effects of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD.

RESULTS

Long-term statin therapy was much more effective in the CKD + CAD patients compared with CKD patients. In the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P = 0.012). With regard to the all-cause and cardiac deaths, long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001). In contrast, long-term statin therapy exerted no significant influence on the clinical outcomes of the CKD-only patients.

CONCLUSION

Long-term statin therapy more dramatically reduced the CVs and mortality rates of the CKD patients with concomitant CAD. In contrast, CKD-only patients had a good prognosis and did not appear to require statin treatment.

Authors+Show Affiliations

Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China. shenhaojyk@126.com.Department of Internal Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Nephrology, First People's Hospital of Wujiang District, Nantong University, Suzhou, China. xyfrancecrazy@163.com.Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Clinical Laboratory Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Internal Medicine, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.Department of Central Laboratory, First People's Hospital of Wujiang District, Nantong University, Suzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29665812

Citation

Shen, Hao, et al. "Effects of Statin Therapy On Chronic Kidney Disease Patients With Coronary Artery Disease." Lipids in Health and Disease, vol. 17, no. 1, 2018, p. 84.
Shen H, Chen X, Lu J, et al. Effects of statin therapy on chronic kidney disease patients with coronary artery disease. Lipids Health Dis. 2018;17(1):84.
Shen, H., Chen, X., Lu, J., Yang, H., Xu, Y., Zhu, A., Zhang, X., Ye, F., & Gu, Y. (2018). Effects of statin therapy on chronic kidney disease patients with coronary artery disease. Lipids in Health and Disease, 17(1), 84. https://doi.org/10.1186/s12944-018-0742-4
Shen H, et al. Effects of Statin Therapy On Chronic Kidney Disease Patients With Coronary Artery Disease. Lipids Health Dis. 2018 Apr 17;17(1):84. PubMed PMID: 29665812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of statin therapy on chronic kidney disease patients with coronary artery disease. AU - Shen,Hao, AU - Chen,Xiaodong, AU - Lu,Jingfen, AU - Yang,Honglin, AU - Xu,Yan, AU - Zhu,Ao, AU - Zhang,Xiao, AU - Ye,Fulong, AU - Gu,Yongchun, Y1 - 2018/04/17/ PY - 2018/01/09/received PY - 2018/04/09/accepted PY - 2018/4/19/entrez PY - 2018/4/19/pubmed PY - 2018/9/18/medline KW - Cardiovascular events KW - Chronic kidney disease KW - Statin SP - 84 EP - 84 JF - Lipids in health and disease JO - Lipids Health Dis VL - 17 IS - 1 N2 - BACKGROUND: Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in CKD + CAD patients. METHODS: We compared the effects of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD. RESULTS: Long-term statin therapy was much more effective in the CKD + CAD patients compared with CKD patients. In the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P = 0.012). With regard to the all-cause and cardiac deaths, long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001). In contrast, long-term statin therapy exerted no significant influence on the clinical outcomes of the CKD-only patients. CONCLUSION: Long-term statin therapy more dramatically reduced the CVs and mortality rates of the CKD patients with concomitant CAD. In contrast, CKD-only patients had a good prognosis and did not appear to require statin treatment. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/29665812/Effects_of_statin_therapy_on_chronic_kidney_disease_patients_with_coronary_artery_disease_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0742-4 DB - PRIME DP - Unbound Medicine ER -