Tags

Type your tag names separated by a space and hit enter

A community-based physical activity intervention to prevent mobility-related disability for retired older people (REtirement in ACTion (REACT)): study protocol for a randomised controlled trial.
Trials. 2018 Apr 17; 19(1):228.T

Abstract

BACKGROUND

The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability.

METHODS/DESIGN

A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention. The REACT study incorporates comprehensive process and economic evaluation and a nested sub-study which will test the hypothesis that the REACT intervention will slow the rate of brain atrophy and of decline in cognitive function assessed using magnetic resonance imaging (MRI). Outcome data will be collected at baseline, 6, 12 and 24 months for the main study, with MRI sub-study data collected at baseline, 6 and 12 months. The primary outcome analysis (SPPB score at 24 months) will be undertaken blinded to group allocation. Primary comparative analyses will be on an intention-to-treat (ITT) basis with due emphasis placed on confidence intervals.

DISCUSSION

REACT represents the first large-scale, pragmatic, community-based trial in the UK to target the non-disabled but high-risk segment of the older population with an intervention to reduce mobility-related disability. A programme that can successfully engage this population in sufficient activity to improve strength, aerobic capacity, coordination and balance would have a major impact on sustaining health and independence. REACT is also the first study of its kind to conduct a full economic and comprehensive process evaluation alongside the RCT. If effective and cost-effective, the REACT intervention has strong potential to be implemented widely in the UK and elsewhere.

TRIAL REGISTRATION

ISRCTN, ID: ISRCTN45627165 . Retrospectively registered on 13 June 2016. Trial sponsor: University of Bath. Protocol Version 1.5.

Authors+Show Affiliations

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. A.Stathi@bham.ac.uk.Department for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.Department for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.Department for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.Faculty of Health and Applied Sciences (HAS), University of the West of England (UWE Bristol), Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK.Wellcome Centre for Integrative Neuroimaging, FMRIB, John Radcliffe Hospital, University of Oxford, Oxford, UK.Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. Global Brain Health Institute, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.Department for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.Department for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.Wellcome Centre for Integrative Neuroimaging, FMRIB, John Radcliffe Hospital, University of Oxford, Oxford, UK.Department of Epidemiology and Public Health, University of Maryland, School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201-1559, USA.Department of Health and Exercise Science, Wake Forest University, Worrell Professional Center 2164B, PO Box 7868, Winston-Salem, NC, 27109, USA.Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, BS8 1TZ, UK.

Pub Type(s)

Clinical Trial Protocol
Journal Article

Language

eng

PubMed ID

29665854

Citation

Stathi, Afroditi, et al. "A Community-based Physical Activity Intervention to Prevent Mobility-related Disability for Retired Older People (REtirement in ACTion (REACT)): Study Protocol for a Randomised Controlled Trial." Trials, vol. 19, no. 1, 2018, p. 228.
Stathi A, Withall J, Greaves CJ, et al. A community-based physical activity intervention to prevent mobility-related disability for retired older people (REtirement in ACTion (REACT)): study protocol for a randomised controlled trial. Trials. 2018;19(1):228.
Stathi, A., Withall, J., Greaves, C. J., Thompson, J. L., Taylor, G., Medina-Lara, A., Green, C., Bilzon, J., Gray, S., Johansen-Berg, H., Sexton, C. E., Western, M. J., de Koning, J. L., Bollen, J. C., Moorlock, S. J., Demnitz, N., Seager, P., Guralnik, J. M., Jack Rejeski, W., & Fox, K. R. (2018). A community-based physical activity intervention to prevent mobility-related disability for retired older people (REtirement in ACTion (REACT)): study protocol for a randomised controlled trial. Trials, 19(1), 228. https://doi.org/10.1186/s13063-018-2603-x
Stathi A, et al. A Community-based Physical Activity Intervention to Prevent Mobility-related Disability for Retired Older People (REtirement in ACTion (REACT)): Study Protocol for a Randomised Controlled Trial. Trials. 2018 Apr 17;19(1):228. PubMed PMID: 29665854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A community-based physical activity intervention to prevent mobility-related disability for retired older people (REtirement in ACTion (REACT)): study protocol for a randomised controlled trial. AU - Stathi,Afroditi, AU - Withall,Janet, AU - Greaves,Colin J, AU - Thompson,Janice L, AU - Taylor,Gordon, AU - Medina-Lara,Antonieta, AU - Green,Colin, AU - Bilzon,James, AU - Gray,Selena, AU - Johansen-Berg,Heidi, AU - Sexton,Claire E, AU - Western,Max J, AU - de Koning,Jolanthe L, AU - Bollen,Jessica C, AU - Moorlock,Sarah J, AU - Demnitz,Naiara, AU - Seager,Poppy, AU - Guralnik,Jack M, AU - Jack Rejeski,W, AU - Fox,Ken R, Y1 - 2018/04/17/ PY - 2017/10/31/received PY - 2018/03/14/accepted PY - 2018/4/19/entrez PY - 2018/4/19/pubmed PY - 2019/6/19/medline KW - Disability prevention KW - Frailty KW - Mobility disability KW - Older adults KW - Physical activity KW - Physical function KW - Randomised control trial SP - 228 EP - 228 JF - Trials JO - Trials VL - 19 IS - 1 N2 - BACKGROUND: The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/DESIGN: A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention. The REACT study incorporates comprehensive process and economic evaluation and a nested sub-study which will test the hypothesis that the REACT intervention will slow the rate of brain atrophy and of decline in cognitive function assessed using magnetic resonance imaging (MRI). Outcome data will be collected at baseline, 6, 12 and 24 months for the main study, with MRI sub-study data collected at baseline, 6 and 12 months. The primary outcome analysis (SPPB score at 24 months) will be undertaken blinded to group allocation. Primary comparative analyses will be on an intention-to-treat (ITT) basis with due emphasis placed on confidence intervals. DISCUSSION: REACT represents the first large-scale, pragmatic, community-based trial in the UK to target the non-disabled but high-risk segment of the older population with an intervention to reduce mobility-related disability. A programme that can successfully engage this population in sufficient activity to improve strength, aerobic capacity, coordination and balance would have a major impact on sustaining health and independence. REACT is also the first study of its kind to conduct a full economic and comprehensive process evaluation alongside the RCT. If effective and cost-effective, the REACT intervention has strong potential to be implemented widely in the UK and elsewhere. TRIAL REGISTRATION: ISRCTN, ID: ISRCTN45627165 . Retrospectively registered on 13 June 2016. Trial sponsor: University of Bath. Protocol Version 1.5. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/29665854/A_community_based_physical_activity_intervention_to_prevent_mobility_related_disability_for_retired_older_people__REtirement_in_ACTion__REACT__:_study_protocol_for_a_randomised_controlled_trial_ L2 - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2603-x DB - PRIME DP - Unbound Medicine ER -