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Trilineage Hematopoiesis Induced by Low-dose Eltrombopag in a Patient With Fanconi Anemia can be Used as a Bridge to Hematopoietic Stem Cell Transplant.
J Pediatr Hematol Oncol 2019; 41(3):229-232JP

Abstract

Fanconi anemia (FA) is an autosomal recessive, progressive bone marrow failure disorder characterized by congenital defects and marked cancer predisposition. Hematopoietic stem cell transplant is the therapy of choice for FA patients with progressive pancytopenia. These patients receive multiple transfusions for cytopenias. Oxymetholone has been used with variable success to improve cytopenias. Eltrombopag has been shown to induce bilineage or trilineage hematopoiesis in aplastic anemia and patients with myelodysplastic marrow. We report a case of FA where eltrombopag in conjunction with oxymetholone induced trilineage hematopoiesis and eliminated transfusion requirement before transplant, thereby enhancing favorable outcome after hematopoietic stem cell transplant.

Authors+Show Affiliations

Rainbow Babies and Children's Hospital, Division of Pediatric Hematology-Oncology, Case Western University.HCG-MSR Cancer Centre, Bangalore, Karnataka, India.Division of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.Rainbow Babies and Children's Hospital, Division of Pediatric Hematology-Oncology, Case Western University.Rainbow Babies and Children's Hospital, Division of Pediatric Hematology-Oncology, Case Western University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29668547

Citation

Gupta, Ashish, et al. "Trilineage Hematopoiesis Induced By Low-dose Eltrombopag in a Patient With Fanconi Anemia Can Be Used as a Bridge to Hematopoietic Stem Cell Transplant." Journal of Pediatric Hematology/oncology, vol. 41, no. 3, 2019, pp. 229-232.
Gupta A, Palassery R, Meyerson H, et al. Trilineage Hematopoiesis Induced by Low-dose Eltrombopag in a Patient With Fanconi Anemia can be Used as a Bridge to Hematopoietic Stem Cell Transplant. J Pediatr Hematol Oncol. 2019;41(3):229-232.
Gupta, A., Palassery, R., Meyerson, H., Ahuja, S., & Matloub, Y. (2019). Trilineage Hematopoiesis Induced by Low-dose Eltrombopag in a Patient With Fanconi Anemia can be Used as a Bridge to Hematopoietic Stem Cell Transplant. Journal of Pediatric Hematology/oncology, 41(3), pp. 229-232. doi:10.1097/MPH.0000000000001168.
Gupta A, et al. Trilineage Hematopoiesis Induced By Low-dose Eltrombopag in a Patient With Fanconi Anemia Can Be Used as a Bridge to Hematopoietic Stem Cell Transplant. J Pediatr Hematol Oncol. 2019;41(3):229-232. PubMed PMID: 29668547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trilineage Hematopoiesis Induced by Low-dose Eltrombopag in a Patient With Fanconi Anemia can be Used as a Bridge to Hematopoietic Stem Cell Transplant. AU - Gupta,Ashish, AU - Palassery,Rasmi, AU - Meyerson,Howard, AU - Ahuja,Sanjay, AU - Matloub,Yousif, PY - 2018/4/19/pubmed PY - 2018/4/19/medline PY - 2018/4/19/entrez SP - 229 EP - 232 JF - Journal of pediatric hematology/oncology JO - J. Pediatr. Hematol. Oncol. VL - 41 IS - 3 N2 - Fanconi anemia (FA) is an autosomal recessive, progressive bone marrow failure disorder characterized by congenital defects and marked cancer predisposition. Hematopoietic stem cell transplant is the therapy of choice for FA patients with progressive pancytopenia. These patients receive multiple transfusions for cytopenias. Oxymetholone has been used with variable success to improve cytopenias. Eltrombopag has been shown to induce bilineage or trilineage hematopoiesis in aplastic anemia and patients with myelodysplastic marrow. We report a case of FA where eltrombopag in conjunction with oxymetholone induced trilineage hematopoiesis and eliminated transfusion requirement before transplant, thereby enhancing favorable outcome after hematopoietic stem cell transplant. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/29668547/Trilineage_Hematopoiesis_Induced_by_Low-dose_Eltrombopag_in_a_Patient_With_Fanconi_Anemia_can_be_Used_as_a_Bridge_to_Hematopoietic_Stem_Cell_Transplant L2 - http://Insights.ovid.com/pubmed?pmid=29668547 DB - PRIME DP - Unbound Medicine ER -