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Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway.
Oxid Med Cell Longev. 2018; 2018:4740739.OM

Abstract

Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance. Moreover, chemotaxis increased after GNC treatment. RNA-seq analysis showed that GNC regulated genes associated with longevity. We also conducted lifespan assays with a series of worm mutants. The results showed that GNC significantly extended the lifespan of several mutant strains, including eat-2 (ad465), rsks-1 (ok1255), and glp-1 (e2144), suggesting that the prolongevity effect of GNC is independent of the function of these genes. However, GNC failed to extend the lifespan of daf-2 (e1370), age-1 (hx546), and daf-16 (mu86) mutant strains. Our findings suggest that GNC extends the lifespan of C. elegans via the insulin/IGF-1 signalling pathway and may be a potential antiageing agent.

Authors+Show Affiliations

Department of Gynecology, The First Hospital of Jilin University, Changchun, China. Department of Integrated Traditional Chinese Medicine and Western Medicine, Obstetrical and Gynecological Hospital, Fudan University, Shanghai, China.Department of Integrated Traditional Chinese Medicine and Western Medicine, Obstetrical and Gynecological Hospital, Fudan University, Shanghai, China.Department of Integrated Traditional Chinese Medicine and Western Medicine, Obstetrical and Gynecological Hospital, Fudan University, Shanghai, China.Department of Integrated Traditional Chinese Medicine and Western Medicine, Obstetrical and Gynecological Hospital, Fudan University, Shanghai, China.Department of Gynecology, The First Hospital of Jilin University, Changchun, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29670680

Citation

Meng, Fanhui, et al. "Gengnianchun Extends the Lifespan of Caenorhabditis Elegans Via the Insulin/IGF-1 Signalling Pathway." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 4740739.
Meng F, Li J, Rao Y, et al. Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway. Oxid Med Cell Longev. 2018;2018:4740739.
Meng, F., Li, J., Rao, Y., Wang, W., & Fu, Y. (2018). Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway. Oxidative Medicine and Cellular Longevity, 2018, 4740739. https://doi.org/10.1155/2018/4740739
Meng F, et al. Gengnianchun Extends the Lifespan of Caenorhabditis Elegans Via the Insulin/IGF-1 Signalling Pathway. Oxid Med Cell Longev. 2018;2018:4740739. PubMed PMID: 29670680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway. AU - Meng,Fanhui, AU - Li,Jun, AU - Rao,Yanqiu, AU - Wang,Wenjun, AU - Fu,Yan, Y1 - 2018/02/18/ PY - 2017/09/19/received PY - 2017/12/18/accepted PY - 2018/4/20/entrez PY - 2018/4/20/pubmed PY - 2018/9/18/medline SP - 4740739 EP - 4740739 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance. Moreover, chemotaxis increased after GNC treatment. RNA-seq analysis showed that GNC regulated genes associated with longevity. We also conducted lifespan assays with a series of worm mutants. The results showed that GNC significantly extended the lifespan of several mutant strains, including eat-2 (ad465), rsks-1 (ok1255), and glp-1 (e2144), suggesting that the prolongevity effect of GNC is independent of the function of these genes. However, GNC failed to extend the lifespan of daf-2 (e1370), age-1 (hx546), and daf-16 (mu86) mutant strains. Our findings suggest that GNC extends the lifespan of C. elegans via the insulin/IGF-1 signalling pathway and may be a potential antiageing agent. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29670680/Gengnianchun_Extends_the_Lifespan_of_Caenorhabditis_elegans_via_the_Insulin/IGF_1_Signalling_Pathway_ L2 - https://dx.doi.org/10.1155/2018/4740739 DB - PRIME DP - Unbound Medicine ER -