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A new perspective of the hippocampus in the origin of exercise-brain interactions.
Brain Struct Funct. 2018 Jul; 223(6):2527-2545.BS

Abstract

Exercising regularly is a highly effective strategy for maintaining cognitive health throughout the lifespan. Over the last 20 years, many molecular, physiological and structural changes have been documented in response to aerobic exercise training in humans and animals, particularly in the hippocampus. However, how exercise produces such neurological changes remains elusive. A recent line of investigation has suggested that muscle-derived circulating factors cross into the brain and may be the key agents driving enhancement in synaptic plasticity and hippocampal neurogenesis from aerobic exercise. Alternatively, or concurrently, the signals might originate from within the brain itself. Physical activity also produces instantaneous and robust neuronal activation of the hippocampal formation and the generation of theta oscillations which are closely correlated with the force of movements. The repeated acute activation of the hippocampus during physical movement is likely critical for inducing the long-term neuroadaptations from exercise. Here we review the evidence which establishes the association between physical movement and hippocampal neuronal activation and discuss implications for long-term benefits of physical activity on brain function.

Authors+Show Affiliations

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Ave, Urbana, IL, 61801, USA. School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Ave, Urbana, IL, 61801, USA. jrhodes@illinois.edu. Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, USA. jrhodes@illinois.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29671055

Citation

Rendeiro, Catarina, and Justin S. Rhodes. "A New Perspective of the Hippocampus in the Origin of Exercise-brain Interactions." Brain Structure & Function, vol. 223, no. 6, 2018, pp. 2527-2545.
Rendeiro C, Rhodes JS. A new perspective of the hippocampus in the origin of exercise-brain interactions. Brain Struct Funct. 2018;223(6):2527-2545.
Rendeiro, C., & Rhodes, J. S. (2018). A new perspective of the hippocampus in the origin of exercise-brain interactions. Brain Structure & Function, 223(6), 2527-2545. https://doi.org/10.1007/s00429-018-1665-6
Rendeiro C, Rhodes JS. A New Perspective of the Hippocampus in the Origin of Exercise-brain Interactions. Brain Struct Funct. 2018;223(6):2527-2545. PubMed PMID: 29671055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new perspective of the hippocampus in the origin of exercise-brain interactions. AU - Rendeiro,Catarina, AU - Rhodes,Justin S, Y1 - 2018/04/18/ PY - 2018/01/18/received PY - 2018/04/10/accepted PY - 2018/4/20/pubmed PY - 2019/3/1/medline PY - 2018/4/20/entrez KW - Exercise KW - Hippocampus KW - Learning KW - Memory KW - Movement KW - Muscle KW - Myokines KW - Neurogenesis KW - Neuronal activation KW - Physical activity KW - Plasticity KW - Spatial learning KW - Theta rhythm SP - 2527 EP - 2545 JF - Brain structure & function JO - Brain Struct Funct VL - 223 IS - 6 N2 - Exercising regularly is a highly effective strategy for maintaining cognitive health throughout the lifespan. Over the last 20 years, many molecular, physiological and structural changes have been documented in response to aerobic exercise training in humans and animals, particularly in the hippocampus. However, how exercise produces such neurological changes remains elusive. A recent line of investigation has suggested that muscle-derived circulating factors cross into the brain and may be the key agents driving enhancement in synaptic plasticity and hippocampal neurogenesis from aerobic exercise. Alternatively, or concurrently, the signals might originate from within the brain itself. Physical activity also produces instantaneous and robust neuronal activation of the hippocampal formation and the generation of theta oscillations which are closely correlated with the force of movements. The repeated acute activation of the hippocampus during physical movement is likely critical for inducing the long-term neuroadaptations from exercise. Here we review the evidence which establishes the association between physical movement and hippocampal neuronal activation and discuss implications for long-term benefits of physical activity on brain function. SN - 1863-2661 UR - https://www.unboundmedicine.com/medline/citation/29671055/A_new_perspective_of_the_hippocampus_in_the_origin_of_exercise_brain_interactions_ L2 - https://dx.doi.org/10.1007/s00429-018-1665-6 DB - PRIME DP - Unbound Medicine ER -
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