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Combined administration of MK-801 and cycloheximide produces a delayed potentiation of fear discrimination memory extinction.
Behav Neurosci. 2018 Apr; 132(2):99-105.BN

Abstract

Mixed evidence exists regarding the role of N-methyl-D-aspartate (NMDA) receptors in memory reconsolidation. We provide no evidence that NMDA receptors are involved with memory reconsolidation, but instead demonstrate that prereactivation systemic MK-801 injection, combined with postreactivation intrabasolateral amygdala (BLA) cycloheximide infusion, produces a delayed potentiation of extinction learning. These data suggest that an interaction between NMDA antagonism and protein synthesis inhibition may enhance extinction by exerting effects outside of the intended reconsolidation manipulation window. The present work demonstrates a novel pharmacological enhancement of extinction, and underscores the importance of employing proper control procedures in reconsolidation research. (PsycINFO Database Record

Authors+Show Affiliations

Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.Department of Psychology and Center for Neuroscience & Behavior, Miami University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29672107

Citation

Kochli, Daniel E., et al. "Combined Administration of MK-801 and Cycloheximide Produces a Delayed Potentiation of Fear Discrimination Memory Extinction." Behavioral Neuroscience, vol. 132, no. 2, 2018, pp. 99-105.
Kochli DE, Campbell TL, Hollingsworth EW, et al. Combined administration of MK-801 and cycloheximide produces a delayed potentiation of fear discrimination memory extinction. Behav Neurosci. 2018;132(2):99-105.
Kochli, D. E., Campbell, T. L., Hollingsworth, E. W., Lab, R. S., Postle, A. F., Perry, M. M., Mordzinski, V. M., & Quinn, J. J. (2018). Combined administration of MK-801 and cycloheximide produces a delayed potentiation of fear discrimination memory extinction. Behavioral Neuroscience, 132(2), 99-105. https://doi.org/10.1037/bne0000232
Kochli DE, et al. Combined Administration of MK-801 and Cycloheximide Produces a Delayed Potentiation of Fear Discrimination Memory Extinction. Behav Neurosci. 2018;132(2):99-105. PubMed PMID: 29672107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined administration of MK-801 and cycloheximide produces a delayed potentiation of fear discrimination memory extinction. AU - Kochli,Daniel E, AU - Campbell,Tiffany L, AU - Hollingsworth,Ethan W, AU - Lab,Rain S, AU - Postle,Abagail F, AU - Perry,Megan M, AU - Mordzinski,Victoria M, AU - Quinn,Jennifer J, PY - 2018/4/20/entrez PY - 2018/4/20/pubmed PY - 2018/12/12/medline SP - 99 EP - 105 JF - Behavioral neuroscience JO - Behav Neurosci VL - 132 IS - 2 N2 - Mixed evidence exists regarding the role of N-methyl-D-aspartate (NMDA) receptors in memory reconsolidation. We provide no evidence that NMDA receptors are involved with memory reconsolidation, but instead demonstrate that prereactivation systemic MK-801 injection, combined with postreactivation intrabasolateral amygdala (BLA) cycloheximide infusion, produces a delayed potentiation of extinction learning. These data suggest that an interaction between NMDA antagonism and protein synthesis inhibition may enhance extinction by exerting effects outside of the intended reconsolidation manipulation window. The present work demonstrates a novel pharmacological enhancement of extinction, and underscores the importance of employing proper control procedures in reconsolidation research. (PsycINFO Database Record SN - 1939-0084 UR - https://www.unboundmedicine.com/medline/citation/29672107/Combined_administration_of_MK_801_and_cycloheximide_produces_a_delayed_potentiation_of_fear_discrimination_memory_extinction_ L2 - http://content.apa.org/journals/bne/132/2/99 DB - PRIME DP - Unbound Medicine ER -