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SAPHO and CRMO: The Value of Imaging.
Semin Musculoskelet Radiol 2018; 22(2):207-224SM

Abstract

The syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion. The diagnosis may be difficult if there is no skin disease, but attention to characteristic imaging appearances may help avoid misdiagnosis (e.g., infection and tumor) and thereby unnecessary invasive procedures as well as facilitating early diagnosis and appropriate treatment. This article provides an overview of the radiologic appearances of SAPHO/CRMO and relevant pathogenetic, clinical, and pathologic features to facilitate the diagnosis that often requires an interdisciplinary approach including radiologists.

Authors+Show Affiliations

Department of Radiology, Aarhus University Hospital, Aarhus, Denmark. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.Department of Radiology, Aarhus University Hospital, Aarhus, Denmark.Department of Radiology, Hôpital Universitaire des Enfants "Reine Fabiola," Université Libre de Bruxelles, Brussels, Belgium.Department of Musculoskeletal Centre X-Ray, Musculoskeletal Biomedical Research Centre (BRC), Chapel Allerton Hospital, Leeds, United Kingdom.Department of Radiology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29672809

Citation

Jurik, Anne Grethe, et al. "SAPHO and CRMO: the Value of Imaging." Seminars in Musculoskeletal Radiology, vol. 22, no. 2, 2018, pp. 207-224.
Jurik AG, Klicman RF, Simoni P, et al. SAPHO and CRMO: The Value of Imaging. Semin Musculoskelet Radiol. 2018;22(2):207-224.
Jurik, A. G., Klicman, R. F., Simoni, P., Robinson, P., & Teh, J. (2018). SAPHO and CRMO: The Value of Imaging. Seminars in Musculoskeletal Radiology, 22(2), pp. 207-224. doi:10.1055/s-0038-1639469.
Jurik AG, et al. SAPHO and CRMO: the Value of Imaging. Semin Musculoskelet Radiol. 2018;22(2):207-224. PubMed PMID: 29672809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SAPHO and CRMO: The Value of Imaging. AU - Jurik,Anne Grethe, AU - Klicman,Rikke Fuglsang, AU - Simoni,Paolo, AU - Robinson,Philip, AU - Teh,James, Y1 - 2018/04/19/ PY - 2018/4/20/entrez PY - 2018/4/20/pubmed PY - 2018/8/25/medline SP - 207 EP - 224 JF - Seminars in musculoskeletal radiology JO - Semin Musculoskelet Radiol VL - 22 IS - 2 N2 - The syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion. The diagnosis may be difficult if there is no skin disease, but attention to characteristic imaging appearances may help avoid misdiagnosis (e.g., infection and tumor) and thereby unnecessary invasive procedures as well as facilitating early diagnosis and appropriate treatment. This article provides an overview of the radiologic appearances of SAPHO/CRMO and relevant pathogenetic, clinical, and pathologic features to facilitate the diagnosis that often requires an interdisciplinary approach including radiologists. SN - 1098-898X UR - https://www.unboundmedicine.com/medline/citation/29672809/SAPHO_and_CRMO:_The_Value_of_Imaging L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0038-1639469 DB - PRIME DP - Unbound Medicine ER -