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MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited.
Eur J Endocrinol. 2018 Jul; 179(1):R19-R29.EJ

Abstract

The syndrome of primary aldosteronism (PA) is characterized by hypertension with excessive, autonomous aldosterone production and is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. The diagnostic workup of PA is a sequence of three phases comprising screening tests, confirmatory tests and the differentiation of unilateral from bilateral forms. The latter step is necessary to determine the optimal treatment approach of unilateral laparoscopic adrenalectomy (for patients with unilateral PA) or medical treatment with a mineralocorticoid receptor antagonist (for patients with bilateral PA). Since the publication of the revised Endocrine Society guideline 2016, a number of key studies have been published. They challenge the recommendations of the guideline in some areas and confirm current practice in others. Herein, we present the recent developments and current approaches to the medical management of PA.

Authors+Show Affiliations

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany. Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy.Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29674485

Citation

Williams, Tracy Ann, and Martin Reincke. "MANAGEMENT of ENDOCRINE DISEASE: Diagnosis and Management of Primary Aldosteronism: the Endocrine Society Guideline 2016 Revisited." European Journal of Endocrinology, vol. 179, no. 1, 2018, pp. R19-R29.
Williams TA, Reincke M. MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited. Eur J Endocrinol. 2018;179(1):R19-R29.
Williams, T. A., & Reincke, M. (2018). MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited. European Journal of Endocrinology, 179(1), R19-R29. https://doi.org/10.1530/EJE-17-0990
Williams TA, Reincke M. MANAGEMENT of ENDOCRINE DISEASE: Diagnosis and Management of Primary Aldosteronism: the Endocrine Society Guideline 2016 Revisited. Eur J Endocrinol. 2018;179(1):R19-R29. PubMed PMID: 29674485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited. AU - Williams,Tracy Ann, AU - Reincke,Martin, Y1 - 2018/04/19/ PY - 2017/11/26/received PY - 2018/04/18/accepted PY - 2018/4/21/pubmed PY - 2018/6/12/medline PY - 2018/4/21/entrez SP - R19 EP - R29 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 179 IS - 1 N2 - The syndrome of primary aldosteronism (PA) is characterized by hypertension with excessive, autonomous aldosterone production and is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. The diagnostic workup of PA is a sequence of three phases comprising screening tests, confirmatory tests and the differentiation of unilateral from bilateral forms. The latter step is necessary to determine the optimal treatment approach of unilateral laparoscopic adrenalectomy (for patients with unilateral PA) or medical treatment with a mineralocorticoid receptor antagonist (for patients with bilateral PA). Since the publication of the revised Endocrine Society guideline 2016, a number of key studies have been published. They challenge the recommendations of the guideline in some areas and confirm current practice in others. Herein, we present the recent developments and current approaches to the medical management of PA. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/29674485/MANAGEMENT_OF_ENDOCRINE_DISEASE:_Diagnosis_and_management_of_primary_aldosteronism:_the_Endocrine_Society_guideline_2016_revisited_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-17-0990 DB - PRIME DP - Unbound Medicine ER -