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[Proteomics and its application to determine mechanism of action of traditional Chinese medicine].
Zhongguo Zhong Yao Za Zhi 2018; 43(5):904-912ZZ

Abstract

There is no doubt that the traditional Chinese medicine(TCM) is effective, practical and scientific after it was used for thousands of years. However, the mechanisms of action of many TCM are still unclear because of their multi-component, multi-target and multi-level features, which hinder the modernization and internationalization of the TCM. Proteomics is to analyze the composition and activity of intracellular proteins which are changing dynamically from a holistic perspective. It is consistent with the holistic and dynamic views of the TCM and brings about the hope of clarifying the mechanism of action of the TCM. In recent years, great progress has been made in the application of proteomics to determine the mechanism of the TCM. This article introduced the core technologies of proteomics and systematically summarized the applications of proteomics in the study of the mechanism of the Chinese medicinal formulae, single Chinese medicine and monomeric compounds from the TCM to provide innovative ideas and methods for reference.

Authors+Show Affiliations

Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.Guangdong Pharmaceutical University, Guangzhou 510006, China.

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

29676086

Citation

Xin, Ping, et al. "[Proteomics and Its Application to Determine Mechanism of Action of Traditional Chinese Medicine]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 43, no. 5, 2018, pp. 904-912.
Xin P, Kuang HX, Li XL, et al. [Proteomics and its application to determine mechanism of action of traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2018;43(5):904-912.
Xin, P., Kuang, H. X., Li, X. L., Wang, Y., Zhang, B. M., Bu, H., ... Wang, Q. H. (2018). [Proteomics and its application to determine mechanism of action of traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 43(5), pp. 904-912. doi:10.19540/j.cnki.cjcmm.20180118.002.
Xin P, et al. [Proteomics and Its Application to Determine Mechanism of Action of Traditional Chinese Medicine]. Zhongguo Zhong Yao Za Zhi. 2018;43(5):904-912. PubMed PMID: 29676086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Proteomics and its application to determine mechanism of action of traditional Chinese medicine]. AU - Xin,Ping, AU - Kuang,Hai-Xue, AU - Li,Xiao-Liang, AU - Wang,Yu, AU - Zhang,Ben-Mei, AU - Bu,He, AU - Wang,Zhi-Bin, AU - Meng,Yong-Hai, AU - Wang,Yan-Hong, AU - Wang,Qiu-Hong, PY - 2017/11/30/received PY - 2018/4/21/entrez PY - 2018/4/21/pubmed PY - 2019/7/13/medline KW - mechanisms of action KW - proteomics KW - traditional Chinese medicine SP - 904 EP - 912 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 43 IS - 5 N2 - There is no doubt that the traditional Chinese medicine(TCM) is effective, practical and scientific after it was used for thousands of years. However, the mechanisms of action of many TCM are still unclear because of their multi-component, multi-target and multi-level features, which hinder the modernization and internationalization of the TCM. Proteomics is to analyze the composition and activity of intracellular proteins which are changing dynamically from a holistic perspective. It is consistent with the holistic and dynamic views of the TCM and brings about the hope of clarifying the mechanism of action of the TCM. In recent years, great progress has been made in the application of proteomics to determine the mechanism of the TCM. This article introduced the core technologies of proteomics and systematically summarized the applications of proteomics in the study of the mechanism of the Chinese medicinal formulae, single Chinese medicine and monomeric compounds from the TCM to provide innovative ideas and methods for reference. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29676086/[Proteomics_and_its_application_to_determine_mechanism_of_action_of_traditional_Chinese_medicine]_ DB - PRIME DP - Unbound Medicine ER -