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[Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis].
Zhongguo Zhong Yao Za Zhi. 2018 Mar; 43(5):1042-1048.ZZ

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments.

Authors+Show Affiliations

The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.Nanjing University of Chinese Medicine, Nanjing 210023, China.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.Nanjing University of Chinese Medicine, Nanjing 210023, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29676106

Citation

Ning, Li-Qin, et al. "[Medication Regularity and Potential Targets of Professor XU Jing-fan's Prescription for Treating Ulcerative Colitis]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 43, no. 5, 2018, pp. 1042-1048.
Ning LQ, Ye B, Shen H, et al. [Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis]. Zhongguo Zhong Yao Za Zhi. 2018;43(5):1042-1048.
Ning, L. Q., Ye, B., Shen, H., Lu, W. M., Xu, D. H., Yan, J., Tan, C., & Tang, D. C. (2018). [Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 43(5), 1042-1048. https://doi.org/10.19540/j.cnki.cjcmm.2018.0035
Ning LQ, et al. [Medication Regularity and Potential Targets of Professor XU Jing-fan's Prescription for Treating Ulcerative Colitis]. Zhongguo Zhong Yao Za Zhi. 2018;43(5):1042-1048. PubMed PMID: 29676106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis]. AU - Ning,Li-Qin, AU - Ye,Bai, AU - Shen,Hong, AU - Lu,Wei-Min, AU - Xu,Dan-Hua, AU - Yan,Jing, AU - Tan,Chang, AU - Tang,De-Cai, PY - 2017/12/06/received PY - 2018/4/21/entrez PY - 2018/4/21/pubmed PY - 2019/7/13/medline KW - BATMAN-TCM KW - medication regularity KW - molecular target KW - traditional Chinese medicine inheritance KW - ulcerative colitis SP - 1042 EP - 1048 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 43 IS - 5 N2 - Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29676106/[Medication_regularity_and_potential_targets_of_Professor_XU_Jing_fan's_prescription_for_treating_ulcerative_colitis]_ L2 - http://www.diseaseinfosearch.org/result/7285 DB - PRIME DP - Unbound Medicine ER -