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Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators.
Am J Infect Control. 2018 07; 46(7):e49-e55.AJ

Abstract

BACKGROUND

Safe and effective decontamination and reuse of N95 filtering facepiece respirators (FFRs) has the potential to significantly extend FFR holdings, mitigating a potential shortage due to an influenza pandemic or other pandemic events. Ultraviolet germicidal irradiation (UVGI) has been shown to be effective for decontaminating influenza-contaminated FFRs. This study aims to build on past research by evaluating the UVGI decontamination efficiency of influenza-contaminated FFRs in the presence of soiling agents using an optimized UVGI dose.

METHODS

Twelve samples each of 15 N95 FFR models were contaminated with H1N1 influenza (facepiece and strap), then covered with a soiling agent-artificial saliva or artificial skin oil. For each soiling agent, 3 contaminated FFRs were treated with 1 J/cm2 UVGI for approximately 1 minute, whereas 3 other contaminated FFRs remained untreated. All contaminated surfaces were cut out and virus extracted. Viable influenza was quantified using a median tissue culture infectious dose assay.

RESULTS

Significant reductions (≥3 log) in influenza viability for both soiling conditions were observed on facepieces from 12 of 15 FFR models and straps from 7 of 15 FFR models.

CONCLUSIONS

These data suggest that FFR decontamination and reuse using UVGI can be effective. Implementation of a UVGI method will require careful consideration of FFR model, material type, and design.

Authors+Show Affiliations

Engineering Science Division, Applied Research Associates, Panama City, FL.Engineering Science Division, Applied Research Associates, Panama City, FL. Electronic address: dharnish@ara.com.Engineering Science Division, Applied Research Associates, Panama City, FL.Engineering Science Division, Applied Research Associates, Panama City, FL.Engineering Science Division, Applied Research Associates, Panama City, FL.

Pub Type(s)

Evaluation Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

29678452

Citation

Mills, Devin, et al. "Ultraviolet Germicidal Irradiation of Influenza-contaminated N95 Filtering Facepiece Respirators." American Journal of Infection Control, vol. 46, no. 7, 2018, pp. e49-e55.
Mills D, Harnish DA, Lawrence C, et al. Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators. Am J Infect Control. 2018;46(7):e49-e55.
Mills, D., Harnish, D. A., Lawrence, C., Sandoval-Powers, M., & Heimbuch, B. K. (2018). Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators. American Journal of Infection Control, 46(7), e49-e55. https://doi.org/10.1016/j.ajic.2018.02.018
Mills D, et al. Ultraviolet Germicidal Irradiation of Influenza-contaminated N95 Filtering Facepiece Respirators. Am J Infect Control. 2018;46(7):e49-e55. PubMed PMID: 29678452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators. AU - Mills,Devin, AU - Harnish,Delbert A, AU - Lawrence,Caryn, AU - Sandoval-Powers,Megan, AU - Heimbuch,Brian K, Y1 - 2018/04/17/ PY - 2017/10/19/received PY - 2018/02/16/revised PY - 2018/02/17/accepted PY - 2018/4/22/pubmed PY - 2019/9/24/medline PY - 2018/4/22/entrez KW - Decontamination KW - Disinfection KW - Reuse KW - Soiling KW - UVGI KW - Ultraviolet SP - e49 EP - e55 JF - American journal of infection control JO - Am J Infect Control VL - 46 IS - 7 N2 - BACKGROUND: Safe and effective decontamination and reuse of N95 filtering facepiece respirators (FFRs) has the potential to significantly extend FFR holdings, mitigating a potential shortage due to an influenza pandemic or other pandemic events. Ultraviolet germicidal irradiation (UVGI) has been shown to be effective for decontaminating influenza-contaminated FFRs. This study aims to build on past research by evaluating the UVGI decontamination efficiency of influenza-contaminated FFRs in the presence of soiling agents using an optimized UVGI dose. METHODS: Twelve samples each of 15 N95 FFR models were contaminated with H1N1 influenza (facepiece and strap), then covered with a soiling agent-artificial saliva or artificial skin oil. For each soiling agent, 3 contaminated FFRs were treated with 1 J/cm2 UVGI for approximately 1 minute, whereas 3 other contaminated FFRs remained untreated. All contaminated surfaces were cut out and virus extracted. Viable influenza was quantified using a median tissue culture infectious dose assay. RESULTS: Significant reductions (≥3 log) in influenza viability for both soiling conditions were observed on facepieces from 12 of 15 FFR models and straps from 7 of 15 FFR models. CONCLUSIONS: These data suggest that FFR decontamination and reuse using UVGI can be effective. Implementation of a UVGI method will require careful consideration of FFR model, material type, and design. SN - 1527-3296 UR - https://www.unboundmedicine.com/medline/citation/29678452/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-6553(18)30140-8 DB - PRIME DP - Unbound Medicine ER -